The predictive value of metabolic syndrome in the evaluation of pregnancy course and outcome

Abstract

The predictive value of metabolic syndrome in the evaluation of pregnancy course and outcome M. Trisovic1,2, O. Mladenovic3, J. Bila4, K. Lalić5, D. Kisic Tepavcevic6 1Hospital for Gynecology and Obstetrics, University Center zvezdara, Belgrade 2High Health School of Professional Studies, 3Sports Academy, University of Belgrade, Belgrade 4Department for Gynecology and Obstetrics, Clinical Center of Serbia; School of Medicine, University of Belgrad, Belgrade 5Department for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia; School of Medicine, University of Belgrade, Belgrade; 6Institute for Epidemiology, School of Medicine, University of Belgrade, Belgrade (Serbia) Summary Aim: Determining the prevalence of metabolic syndrome (MS) in the tested sample of pregnant women in the second and third trimesters of pregnancy, as well as the prognostic significance of MS in assessing the course and outcome of pregnancy. Materials and Methods: Prospective cohort study included 135 pregnant women after 24 0/7 weeks of pregnancy, hospitalized in the period from the January 1st, 2014 until September 30th, 2014. Data analysis included descriptive and analytical methods. Results: After assessment of possible confounding effect of age the authors confirmed that women with MS were 1,685-fold more likely give birth by caesarean section (OR = 1.685, p = 0.048), that it was a statistically significant prognostic factor in the earlier weeks of delivery (p = 0.001), and that it was statistically significant prognostic factor of lower Apgar scores in infants (p = 0.003). Conclusion: The early detection of MS during pregnancy reduces perinatal morbidity and is an important factor for the pregnancy outcome. Key words: Metabolic syndrome; Obesity; Cesarean section; Gestational diabetes; Gestational hypertension