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Title: | The beneficial effect of luteal phase support on pregnancy rates in women with unexplained infertility |
Authors: | J.H. Check, J.H. Check |
Keywords: | Unexplained infertility Follicle maturation Luteal phase Progesterone supplementation |
Issue Date: | Jun-2019 |
Abstract: | The beneficial effect of luteal phase support on pregnancy rates in women with unexplained infertility J.H. Check 1,2 , J. Liss 2 , D. Check 2 1Cooper Medical School of Rowen University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and infertility, Camden, NJ; 2Cooper Institute For Reproductive Hormonal Disorders, P.C. Marlton, NJ (USA) Summary Purpose: To determine what percentage of women with regular menses and unexplained infertility seem to develop a mature dominant follicle (18-24 mm average diameter and serum estradiol >200 pg/mL). Also to determine the efficacy of empirical progesterone (P) supplementation in the luteal phase for those with unexplained infertility who seem to make mature follicles. Materials and Methods: Serial ultrasounds and serum estradiol levels performed in cases of infertility over one year duration in patients with patent fallopian tubes, normal semen parameters, and normal post-coital test. Vaginal P of different types were given in the luteal phase as exclusive treatment. Results: A viable fetus past the first trimester was found in 71.7% of the 80% of women developing a mature follicle who were treated with P. Conclusions: For the combined effect of efficacy of therapy, cost, convenience, and lack of side effects, supplemental use of P in the luteal phase should be considered as first line therapy for unexplained infertility rather than empirical use of “fertility” drugs and intrauterine insemination or even in vitro fertilization - embryo transfer (IVF-ET). Methods of determining who needs supplemental P are not presently available. Key words: Unexplained infertility; Follicle maturation; Progesterone supplementation; Luteal phase. |
URI: | http://localhost:8080/xmlui/handle/123456789/2133 |
Appears in Collections: | 2. Clinical and Experimental Obstetrics & Gynecology |
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