Plasma urotensin-2 as a marker for menstrual irregularities in women: a clinical study

Abstract

Plasma urotensin-2 as a marker for menstrual irregularities in women: a clinical study D. Cetin 1 , M. Yayla 1 , Y. Baykus 2 , R. Deniz 2 1Department of Pharmacology; 2Department of Gynecology & Obstetrics; Kafkas University Faculty of Medicine, Kars (Turkey) Summary Purpose of Investigation: The objectives of this study were to evaluate urotensin 2 (UT-2) serum levels, a potent vasoconstrictor, in women with irregular menstrual irregularities and to determine its course in irregular menstrual cycles for the first time in the literature. It aims to determine the possible physiological roles of UT-2 by comparing the hormonal changes occurring in women with menstrual irregularities and their UT-2 levels. Materials and Methods: In this study, 120 patients with irregular menstruation was collected on day 3 of the menstrual cycle. Patients were divided into four groups: oligomenorrhea, hypomenorrhea, polymenorrhea, and menorrhagia/ menometrorrhagia. Follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone (TSH), prolactin (PRL), and UT-2 levels were measured in serum. Results: Serum FSH, LH, and TSH levels were not significantly different between the groups. In this study a correlation test between UT-2 and PRL levels was carried out. This resulted in a statistically inverse correlation between increased UT-2 and decreased PRL levels among the groups being shown. Conclusion: It is interesting to note that the levels of urotensin in this study were higher in women with menstrual irregularities than in healthy individuals and that serum PRL levels in women with menstrual irregularities were lower than those in the control group, while still remaining within normal range. Key words: Menstruation; Irregularity;Women; Urotensin 2; Prolactin.