Novel inflammatory markers of labor following premature preterm rupture of membranes

Abstract

Novel inflammatory markers of labor following premature preterm rupture of membranes R. Rzepka 1 , B. Dołęgowska 2 , N. Marczuk 2 , S. Kwiatkowski 1 , A. Rajewska 1 , K. Nurek 1 , A. Torbè 1 1Department of Obstetrics and Gynecology, 2Department of Laboratory Diagnostics, Pomeranian Medical University, Szczecin (Poland) Summary The aim of the study was comparison of levels of resistin (RE), soluble receptor for advanced glycation end products (sRAGE), soluble receptor activator for nuclear factor-κB ligand (sRANKL), osteoprotegerin (OPG), glucose (GL), total protein (TP), and albumin (AL) between women with preterm and term rupture of fetal membranes and evaluation of prognostic values of all above in diagnostic of premature labor. Ninety-eight women in singleton pregnancy presenting with premature rupture of fetal membranes were included and divided into two groups: A – 49 women after 37 weeks and B – 49 women before 36 weeks of gestation. Plasma levels of sRAGE, OPG, TP, and AL were significantly lower in group B, and RE and GL plasma levels were higher in this group. The high prognostic values for sRAGE and sRANKL in the prognosis of spontaneous delivery after preterm rupture of membranes (pPROM) were found. The authors concluded that sRAGE and sRANKL serum levels could be a useful prognostic factors after pPROM. Resistin can play role in pathogenesis of rupture of membranes in premature pregnancy. Key words: Preterm labour; Resistin; sRAGE; esRAGE; sRANKL.