Medical treatment as a possible treating modality for premalignant vulvar lesions

Abstract

Medical treatment as a possible treating modality for premalignant vulvar lesions R. Zivadinovic 1,4 , B. Zivadinovic 2,5 , A. Petric 1,4 , D. Krtinic 3,6 , S.P. Trajkovic Dinic 1,4 1Department for Gynecology and Obstetrics, 2Department for Neurology, 3Department for Pharmacology and Toxicology, Faculty of Medicine, University of Nis, Nis 4Clinic for Gynecology and Obstetrics, 5Clinic for Neurology, 6Clinic for Oncology, Clinical Center Nis, Nis (Serbia) Summary Purpose of investigation: Purpose of this investigation was to determine the possibilities of non-surgical, medical treatment of highgrade squamous intraepithelial lesion (HSIL) of the vulva and differentiated type of vulvar intraepithelial lesions (VIN) and to determine the effect of medical treatment by local and systemic immunomodulators in relation to different histological types. Materials and Methods: The study included five patients with different histological types of VIN. The patients were given: systemic immunomodulator and antivirotics. After that, the patients initially included in the study were followed for a year, while the follow-up of the older patients group is still ongoing, and it has been six months since the completion of the treatment. Results: Combined medical therapy has positive therapeutic effect in the treatment of young HPV-positive adolescent patients with HSIL of the vulva. Medical treatment in HPV negative women with differentiated type VIN is less efficient, achieving partial remission in only 33% of patients. Conclusion: Combined medical therapy achieved better effects in hyperpigmented multifocal type of VIN. Key words: Medicals treatment; Vulvar intraepithelial neoplasia; Adolescence; Menopause; Premalignant lesions.