Anti-NMDAR encephalitis in a 19 year old female patient with ovarian teratoma: A case report

Abstract

Anti-NMDAR encephalitis in a 19 year old female patient with ovarian teratoma: A case report Johnny El Hanna*, Codjo Quenum, Abdelilah Arsalane Department of Obstetrics and Gynecology, Grand Hôpital de l’Est Francilien, France A R T I C L E I N F O Article history: Received 20 March 2021 Accepted 7 June 2021 Available online 12 June 2021 Keywords: Encephalitis Autoimmune Anti-N-Methyl-D-Aspartate Ovarian teratoma A B S T R A C T Background: Anti-N-Methyl-D-Aspartate encephalitis is a subcategory of auto-immune encephalitis. It is known for its aggressive presenting symptoms and rapid deterioration, yet it is treatment responsive. It is associated in 50 % to ovarian teratoma. Case: We report the case of a 19 year old female patient presenting for a psychiatric disorder of sudden onset with rapid deterioration. Neurologic imaging was in favor of encephalitis, and CSF studies revealed Anti NMDA receptors. Further abdominal imaging showed a right ovarian teratoma of 4 cm. Laparoscopic ovarian cyst resection was done, and corticotherapy, IVIG and anticonvulsants were given. We report complete resolution of symptoms after 7 months. Conclusion: Anti-NMDA receptor encephalitis with ovarian teratoma is a rare entity with rapid deterioration. Early diagnosis, surgical resection and proper medical treatment are essential for the management of this disease.