The relationship between vitamin D and IVF: a systematic review and meta-analysis Chunjuan Shen 1 , Liping Wang 1 , Xiaojie Wu 1 , Shuh

Abstract

The relationship between vitamin D and IVF: a systematic review and meta-analysis Chunjuan Shen 1 , Liping Wang 1 , Xiaojie Wu 1 , Shuhui Mao 1 , Chunxia Fang 1 1 Department of Obstetrics and Gynecology, Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang (China) Summary Vitamin D deficiency does not influence IVF outcomes, but is related to lower pregnancy and it is important to provide more reli- able evidence on vitamin D in IVF due o the published studies which are strongly contradictory. Objectives: To explore the effect of vitamin D in IVF with a focus on the outcome of clinical pregnancy in published studies. Materials and Methods: The authors used PubMed, EMBASE, Web of knowledge (SCI), and Cochrane Library Methods to explore all studies that evaluate vitamin D levels and IVF outcomes until 2016. Risk ratios (RRs) and 95% confidence intervals (CIs) were calculated for analyses. Result: The authors first classified two groups to investigate the influence of vitamin D in IVF. There was no significant difference with deficient vitamin D and IVF outcome (RR 0.88, 95% CI 0.74-1.04; I2 63%, seven trials; 1,865 participants). In addition, vitamin D deficiency also di not show a significant difference in IVF outcome (RR 0.91, 95 % CI 0.77–1.18, RR 0.91, 95% CI, 0.77-1.18; I2, 72 trials, 1,172 participants). Conclusion: There is no significance between vitamin D status (deficiency or replete) and IVF outcomes, but it was also found that vitamin D deficiency was inclined to lower IVF pregnancy outcome.