Prevalence of human papillomavirus infection in oocyte donors and women treated for infertility: An observational laboratory-based study

Abstract

Prevalence of human papillomavirus infection in oocyte donors and women treated for infertility: An observational laboratory-based study$ Hana Jaworeka,1, Blazena Zborilovab,1, Vladimira Koudelakovaa, Jana Brezinovac, Jana Vrbkovaa, Ivana Obornab,*, Marian Hajducha,d,* a Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, 77900, Czech Republic b Fertimed Ltd., Olomouc, 77600, Czech Republic c Arleta IVF Ltd., Kostelec nad Orlici, 517 41, Czech Republic d Cancer Research Czech Republic, Olomouc, 77900, Czech Republic A R T I C L E I N F O Article history: Received 22 March 2019 Received in revised form 6 June 2019 Accepted 11 June 2019 Available online 4 July 2019 Keywords: Human papillomavirus Infertility In vitro fertilization Pregnancy Oocyte donor A B S T R A C T Objective: The aims of this study were to determine the prevalence of human papillomavirus (HPV) infection in women treated for infertility and oocyte donors, and to investigate the possible influence of HPV infection on reproductive outcomes. Study design: In this observational laboratory-based study, cervical swabs were collected from oocyte donors (n = 207), and women treated for infertility (n = 945) and analysed for the presence of high-risk HPV (hrHPV) genotypes using the cobas1 4800 HPV Test and PapilloCheck1 HPV-Screening. Associations between hrHPV positive status and fertility outcome or socio-behavioral and health characteristics were evaluated using R statistical software. Results: HrHPV prevalence was significantly higher in oocyte donors than in women treated for infertility (28.0% vs.16.1%, P < 0.001). Women who became pregnant spontaneously (19.6%) and women not treated with in vitro fertilization (IVF, 18.1%) were more frequently hrHPV positive than women treated with IVF (12.7%, P = 0.077). Despite the high prevalence of hrHPV in both oocyte donors and infertile women, no associations between hrHPV positive status and pregnancy or abortion rates were found in IVF treated women or in oocyte recipients. Moreover, no associations between hrHPV positive status and abortion rates were found in spontaneously pregnant women. Conclusion: Despite the high prevalence of hrHPV in both oocyte donors and infertile women, HPV infection did not influence the outcomes of assisted reproductive technology.