Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/1961
Title: Gestational and perinatal outcomes in recurrent miscarriages couples treated with lymphocyte immunotherapy
Authors: Sarno, Manoel
Keywords: Lymphocyte immunotherapy Recurrent miscarriage Gestation Perinatal outcomes
Issue Date: Jul-2019
Abstract: Gestational and perinatal outcomes in recurrent miscarriages couples treated with lymphocyte immunotherapy Manoel Sarnoa, Marcelo Borges Cavalcanteb, Marla Niaga, Kleber Pimentela, Ivana Luzc, Bianca Figueiredod, Tatiana Michelone, Jorge Neumanne, Simone Limaf, Isabela Nelly Machadof, Edward Araujo Júniorg,*, Ricardo Barinih a Department of Obstetrics and Gynecology, Federal University of Bahia (UFBA), Salvador, BA, Brazil b Department of Obstetrics and Gynecology, Fortaleza University (UNIFOR), Fortaleza, CE, Brazil c Aloimune Reproductive Immunology Centre, Salvador, BA, Brazil d Reproductive Immunology Centre, Rio de Janeiro, RJ, Brazil e Reproductive Immunology Centre, Porto Alegre, RS, Brazil f Allovita Reproductive Immunology Centre, Campinas, SP, Brazil g Department of Obstetrics, Paulista School of Medicine–Federal University of São Paulo (EPM-UNIFESP), São Paulo, SP, Brazil h Department of Obstetrics and Gynecology, State University of Campinas (UNICAMP), Campinas, SP, Brazil A R T I C L E I N F O Article history: Received 7 December 2018 Received in revised form 7 April 2019 Accepted 29 April 2019 Available online 7 May 2019 Keywords: Lymphocyte immunotherapy Recurrent miscarriage Gestation Perinatal outcomes A B S T R A C T Objective: This study aims to elucidate which types of recurrent miscarriage (RM) patients experienced a livebirth after paternal lymphocyte immunotherapy (LIT) and to evaluate the perinatal outcome. Study design: Retrospective analysis of a multicenter, observational study which enrolled 1096 couples with a history of two or more spontaneous miscarriages without any intercalated delivery. We conducted an intention-to-treat analysis of couples with RM treated with or without LIT regarding to gestational and perinatal outcomes. We compared groups by using the Student’s t-test or Kruskal–Wallis test, Fisher’s exact-test and χ2 test when appropriate. Results: The success of gestation was significantly higher in the LIT group (60.1% vs. 33.1%; p < 0.001). A sub-analysis of four different immune disorder groups revealed a significantly higher success in the LIT group in all immune categories, except in patients who had autoantibodies positive. We observed no significant differences in perinatal outcomes such as gestational age at birth, preterm and extreme preterm birth, and birth weight in successful pregnancy in both groups. The success rate was significantly higher when LIT was administrated before and during pregnancy and only during pregnancy compared to only before pregnancy (p < 0.01). Conclusions: Careful laboratory test phenotyping of RM patients may identify subgroups most likely to benefit and exclude those with little likelihood of benefit, and LIT during a pregnancy may significantly improve success rates.
URI: http://localhost:8080/xmlui/handle/123456789/1961
Appears in Collections:1. European Journal of Obstetrics & Gynecology and Reproductive Biology

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