Are intra follicular estradiol and oocytes quality in women undergoing assisted reproductive technology different between the right and left ovaries? An observational study

Abstract

Are intra follicular estradiol and oocytes quality in women undergoing assisted reproductive technology different between the right and left ovaries? An observational study Robabeh Taheripanaha, Marzieh Zamaniyanb,c,*, Mohammadali Karimzadeh Meybodid, Mohamad hossein Amir-arjmande, Ardalan Mansourif, Anahita Taheripanahg, Narges Malihh a Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran b Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran c Infertility Center, Department of Obstetrics and Gynecology, Mazandaran University of Medical Sciences, Sari, Iran d Shahid Sadoughi University of Medical Sciences, Yazd, Iran e Madar Hospital, Yazd, Iran f Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran g Department of Molecular and Cellular Sciences, Faculty of Advanced Sciences and Technology Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran h Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran A R T I C L E I N F O Article history: Received 22 July 2018 Received in revised form 13 April 2019 Accepted 10 May 2019 Available online 11 May 2019 Keywords: Estradiol Oocyte Ovary Ovulation Sperm injections Intracytoplasmic A B S T R A C T Objective: Controlled Ovarian Stimulation (COS) for In-Vitro Fertilization (IVF) or Intracytoplasmic Sperm Injection (ICSI) is considered as an assisted reproduction technology. There are established structural and biological differences between both ovaries which may affect their responsiveness to COS. Whether the right or the left ovary responds superior to COS is a question which is unresolved in the literature. Study design: The present study was conducted as a prospective observational to make a comparison between right and left ovaries’ oocytes based on oocyte quality and follicular fluid estradiol level. A total of 100 infertile women who had referred to Infertility and Reproductive Health Research center at Shahid Beheshti University of Medical Sciences, Tehran, Iran, were investigated. Results: The total number of very good and good oocytes were 63.01% vs. 50.3%, and immature and interstitial oocytes were 36.99% vs. 49.6% in the right and the left ovaries, respectively. There were no significant differences between oocyte rates between the two ovaries (P > 0.05). Conclusion: Good and very good quality oocytes and fertilization rate (P < 0.001) are higher in the right ovary compared with the left ovary; however, no significant difference was observed between the right and the left ovaries in oocyte yields and cleavage rates. Moreover, despite higher follicular estradiol levels in the left ovary, there was no relationship noticed between follicular fluid estradiol and oocyte quality among oocytes of each ovary.