Polycystic ovary syndrome (PCOS) and genetic predisposition: A review article

Abstract

Polycystic ovary syndrome (PCOS) and genetic predisposition: A review article Nida Ajmal, Sanam Zeib Khan, Rozeena Shaikh* Department of Biotechnology, Faculty of Life Sciences and Informatics, Balochistan University of Information Technology, Engineering and Management Sciences (BUITEMS), Quetta, Balochistan, Pakistan A R T I C L E I N F O Article history: Received 1 April 2019 Received in revised form 27 May 2019 Accepted 30 May 2019 Available online 8 June 2019 Keywords: Polycystic ovary syndrome Infertility Hormonal disbalance Endocrine reproductive disorder A B S T R A C T Polycystic ovary syndrome (PCOS) is a heterogeneous condition which is related to an endocrine reproductive disorder of females. It affects females of 18–44 age. The persistent hormonal disbalance leads to the complexities such as numerous cysts, an irregular menstrual cycle that ultimately leads to infertility among females. Many candidate genes have been identified to be one of the causes of PCOS. Different studies have been carried out to find the genetic correlation of PCOS. It is essential to carry out such studies that identify the clear cause of PCOS and its genetic association and hormonal disbalance. This review has highlighted different genes and their correlation with PCOS that leads to hormonal disbalance. Yet not in-depth but an attempt to study the genetic predisposition of PCOS.