Hubungan pengetahuan dengan kepatuhan pada pasien acquired immune deficiency syndrome dalam mengonsumsi obat Antiretroviral

Abstract

Abstract Background: Human Immunodeficiency Virus (HIV) is a class of viruses that infect white blood cells and cause decreased immunity, while Acquired Immune Deficiency Syndrome (AIDS) is a set of symptoms that arise due to the human immune system that drops due to infection by HIV. HIV patients really need Antiretroviral (ARV) treatment to reduce the number of HIV viruses so as not to enter the AIDS stage, while AIDS patients need ARV treatment to prevent opportunistic infections with various complications. The most important factor in the success of ARV therapy is compliance in taking ARV drugs. Purpose: To determine the relationship between knowledge of Acquired Immune Deficiency Syndrome (AIDS) patients and compliance with taking Antiretroviral drugs. Method: Descriptive research with a cross-sectional approach. The study was conducted on HIV-infected patients at the Sentani Health Center, Jayapura Regency, which was carried out from December 2, 2022 to July 30, 2023. The independent variable in this study was the knowledge of HIV patients, while the dependent variable was adherence to taking ARVs. The sampling technique was accidental sampling, the calculation used the Slovin formula and the number of samples was 69 respondents. Univariate and bivariate data analysis used the chisquare statistical test. Results: Respondents with good knowledge did not make them compliant in taking drugs, as shown by the value of high compliance 16 (61.6%) respondents, moderate 12 (50.0%) respondents, and low compliance 7 (37.0%) respondents. This score does not have a significant difference, so the results of the chi square test show that there is no relationship between knowledge and compliance of HIV/AIDS patients in taking ARV drugs with a pvalue of 0.137 (>0.05). Conclusion: There is no relationship between knowledge and compliance of HIV/AIDS patients in taking ARV drugs, this occurs because compliance with ARV therapy can not only be influenced by the level of knowledge, but is influenced by many factors such as individual awareness and motivation, inability to tolerate side effects of drugs, as well as family support and laziness to take drugs when they run out. Suggestion: Nurses can continue to provide counseling and health education to HIV/AIDS patients to continue to improve compliance in taking drugs. For further research, it is recommended to add other variables that are indicated as factors of drug compliance. Keywords: Acquired Immune Deficiency Syndrome (AIDS); Antiretroviral (ARV); Compliance; Knowledge.