Evaluasi sensitivitas dan spesifisitas Xpert MTB RIF dan Xpert MTB RIF Ultra pada berbagai spesimen untuk mendiagnosis tuberkulosis ekstra paru: Sebuah telaah literatur sistematis

Abstract

Abstract Background: Molecular examination using Xpert MTB RIF and Xpert MTB RIF Ultra was introduced by WHO in 2010 as a fast and practical supporting examination in detecting Mycobacterium tuberculosis. However, not many studies have reported how sensitive and specific this method is in the examination of various specimens in establishing the diagnosis of extrapulmonary tuberculosis. Purpose: To evaluate the sensitivity and specificity of Xpert MTB RIF and Xpert MTB RIF Ultra on various specimens to establish the diagnosis of extrapulmonary tuberculosis. Method: Systematic literature review by searching literature published in reputable international journals in the last 5 years using the keywords Xpert MTB RIF for EPTB. The search was carried out using the literature search engines Mendeley.com and Science Direct.com. Results: The Xpert MTB RIF examination has different sensitivity and specificity for different specimen sources, this is influenced by the place where the specimen was taken, the technique of taking the specimen and the shape of the specimen being examined. Xpert MTB RIF Ultra has higher sensitivity and specificity compared to Xpert MTB RIF. Conclusion: In each study the sensitivity values were different, this could be due to differences in the location of specimen collection, the specimens used, as well as differences in the gold reference standard used. Keywords: Electronically Transmitted Postal Ballot; Mycobacterium Tuberculosis; Sensitivity; Specificity; Xpert MTB RIF; Xpert MTB RIF Ultra.