Neuroendocrine Cervical Carcinoma

Abstract

Objective: To present a case series of neuroendocrine cervical carcinoma, a rare malignancy of the cervix characterized by varying stages, treatment approaches, and outcomes. The article provides a comprehensive review of diagnostic strategies, treatment modalities, and prognostic considerations for managing neuroendocrine cervical carcinoma. Methods: Case report Cases: Three cases of neuroendocrine cervical carcinoma are reported. The fi rst case involves a 40-year-old woman, para 2, diagnosed with stage IIIB neuroendocrine cervical carcinoma, who opted for palliative care. The second case features a 54-year-old woman, para 5, with stage IIB neuroendocrine cervical carcinoma, treated with radiotherapy and achieving a disease-free period of 4 months. The third case showcases a 36-year-old woman, para 2, diagnosed with stage IB1 neuroendocrine cervical carcinoma. She underwent a radical abdominal hysterectomy with pelvic lymphadenectomy and external pelvic radiotherapy, achieving disease control without recurrence for 15 years. Conclusion: Distinguishing neuroendocrine cervical carcinoma from other cervical malignancies is crucial, with immunohistochemistry (IHC) offering valuable diagnostic insights. Tailored treatment plans are essential for managing these malignancies, with a preference for multimodality approaches to enhance overall outcomes.