http://localhost:8080/xmlui/handle/123456789/9515 523 - 667 Thu, 09 Apr 2026 02:19:56 GMT 2026-04-09T02:19:56Z http://localhost:8080/xmlui/handle/123456789/9531 Title: Nonbacterial thrombotic endocarditis mimics acute infective endocarditis in a woman with endometrial cancer Thu, 01 Aug 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/9531 2024-08-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/9530 Title: Antimicrobial resistance profile in Salmonella enterica serovar Choleraesuis isolates from diseased pigs in Taiwan Authors: Xuan, Anh Le; Hsu, Feng-Yang; Hsueh, Po-Ren; dkk. Abstract: This study investigated antimicrobial resistance in Salmonella enterica serovar Choleraesuis (S. Choleraesuis) isolates from diseased pigs in Taiwan (2015e2020). Among 272 isolates, florfenicol (96.7%), enrofloxacin (96.3%), doxycycline (91.2%), gentamicin (84.6%), and tiamulin (80.5%) exhibited high resistance. 99.3% of the isolates were resistant to at least one antibiotic, and 97.8% of the isolates were multidrug resistant. This study illustrated that S. Choleraesuis isolates exhibited high resistance to antimicrobials currently used in the Taiwanese swine industry. Thu, 01 Aug 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/9530 2024-08-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/9529 Title: Curative effects and mechanisms of AG1296 and LY294002 co-therapy in Angiostrongylus cantonensis-induced neurovascular unit dysfunction and eosinophilic meningoencephalitis Authors: Chen, Ke-Min; Lai, Shih-Chan Abstract: Background: Co-therapy with albendazole and steroid is commonly used in patients with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis infections. However, anthelminthics often worsen symptoms, possibly due to the inflammatory reaction to antigens released by dying worms. Therefore, the present study was to investigate the curative effects and probable mechanisms of the platelet-derived growth factor receptor-beta (PDGFRb) inhibitor AG1296 (AG) and the phosphoinositide 3-kinase inhibitor (PI3K) LY294002 (LY) in A. cantonensis-induced neurovascular unit dysfunction and eosinophilic meningoencephalitis. Methods: Western blots were used to detect matrix protein degradation and the expressions of PDGFR-b/PI3K signaling pathway. The co-localization of PDGFR-b and vascular smooth muscle cells (VSMCs), and metalloproteinase-9 (MMP-9) and VSMCs on the blood vessels were measured by confocal laser scanning immunofluorescence microscopy. Sandwich enzyme-linked immunosorbent assays were used to test S100B, interleukin (IL)-6, and transforming growth factor beta in the cerebrospinal fluid to determine their possible roles in mouse resistance to A. cantonensis. Results: The results showed that AG and LY cotherapy decreased the MMP-9 activity and inflammatory reaction. Furthermore, S100B, IL-6 and eosinophil counts were reduced by inhibitor treatment. The localization of PDGFR-b and MMP-9 was observed in VSMCs. Furthermore, we showed that the degradation of the neurovascular matrix and blood-brain barrier permeability were reduced in the mouse brain. Conclusions: These findings demonstrate the potential of PDGFR-b inhibitor AG and PI3K inhibitor LY co-therapy as anti-A. cantonensis drug candidates through improved neurovascular unit dysfunction and reduced inflammatory response. Thu, 01 Aug 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/9529 2024-08-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/9528 Title: Detection of trichomonads in patients with lung cancer and transcription analysis on the response of human pulmonary epithelial cells to Trichomonas tenax invasion Authors: Chen, Chun-Hsien; Kuo, Chin-Wei; Tsai, Chih-Ming; dkk. Abstract: Introduction: Lung cancer is one of the most prevalent malignancies worldwide. Substantial research has illuminated the intricate interplay between microorganisms and human health, revealing their role in disease regulation. Trichomonads is a flagellated protozoan in the human cavity and have been previously identified as a pathogen associated with pneumonia, contributing to tissue chronic inflammation and carcinogenesis. Methods: Nested polymerase chain reaction methods were employed to scrutinize the prevalence of trichomonads in the bronchovesicular fluid of patients diagnosed with lung cancer. Subsequently, the influence of Trichomonas tenax invasion on lung cancer cells was elucidated through proliferation assays, migration assays, and transcription analysis. Results: Bronchoalveolar fluid samples from lung cancer patients yielded positive nested PCR results for eight out of twenty-seven samples. Seven of these samples were identified as Trichomonas tenax, while one was identified as Tetratrichomonas spp. Our findings revealed a significant upregulation of pathways associated with carcinogenesis, including cellular proliferation, migration, and drug resistance, in response to T. tenax invasion. Conclusions: This study underscores the importance of recognizing the presence of trichomonads and the influence of T. tenax invasion on host responses to respiratory diseases. The identified pathways implicated in cancer development may pave the way for developing targeted treatment strategies for pulmonary diseases. These findings hold promise for informing and improving the precision of therapeutic interventions in the context of pulmonary ailments. Thu, 01 Aug 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/9528 2024-08-01T00:00:00Z