http://localhost:8080/xmlui/handle/123456789/8948 Wed, 08 Apr 2026 21:38:27 GMT 2026-04-08T21:38:27Z http://localhost:8080/xmlui/handle/123456789/12238 Title: Culture-negative orthopedic implant-associated infection due to Mycoplasma hominis: A case report Sat, 01 Mar 2025 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/12238 2025-03-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/12237 Title: Oseltamivir-resistant influenza in a fatal immunocompromised adult Sat, 01 Mar 2025 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/12237 2025-03-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/12236 Title: Unanticipated cytotoxicity of fusidic acid in antibiotic-loaded hydrogel Authors: Jiang, Jing-Gu; Chen, Yu-Chun; Chen, Yu-Chun; Jiang, Ni-En; Liao, Chun-Hsing; Chang, Chih-Hung Abstract: This study evaluated the cytotoxicity of fusidic acid-loaded HA hydrogels on different cell types. Results show significant cytotoxicity, especially at concentrations above 0.1 %, with MC3T3 cells being the most sensitive. These findings highlight the importance of considering cell-specific responses and cytotoxic effects when designing antibiotic-loaded hydrogels for biomedical applications. Sat, 01 Feb 2025 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/12236 2025-02-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/12235 Title: The therapeutic impact of maximum chemotherapy possession days during three consecutive months in non-tuberculous mycobacterial lung disease: A real-world experience Authors: Wang, Ping-Huai; Wei, Yu-Feng; Liu, Chia-Jung; Chen, Chung-Yu; Lin, Shu-Wen; Pan, Sheng-Wei; Wang, Su-Mei Abstract: Purpose: Adherence to guideline recommendations in the treatment of non-tuberculous mycobacterial lung disease (NTM-LD) is often difficult. Thus, this study aimed to investigate the impact of the integrity of NTM-LD treatment on treatment outcomes. Materials and methods: The participants were screened from the National Taiwan University Hospital-Integrative Medical Database (NTUH-iMD) and the Taiwan National Health Insurance Research Database (NHIRD). The longest treatment duration during 3 consecutive months was defined as maximum chemotherapy possession days (MCPDs) and was categorized as low (28–55 days), medium (56–90 days), and maximum (≥91 days). We analyzed microbiological cure and 3-year mortality using MCPDs. Results: Low, medium, and maximum MCPD groups had 83 (19.2 %), 94 (21.8 %), and 255 (59.0 %) participants in the NTUH-iMD cohort (N = 432) and 1203 (26.5 %), 1251 (27.6 %), and 2084 (45.9 %) participants in the NHIRD cohort (N = 4538), respectively. In the NTUH-iMD cohort, multivariable analysis showed that adjusted hazard ratios (aHRs) of 3-year mortality were 0.51 (95 % CI: 0.29–0.90) and 0.29 (0.18–0.49) in medium and maximum MCPD groups compared with the low MCPD group. The trends of survival benefit by maximum MCPDs were also found in the NHIRD cohort. The maximum MCPD group had 45.9 % participants with microbiologic cure, which was significantly higher than in medium and low MCPD groups (27.7 % and 4.0 %, respectively; p < 0.001). Conclusion: Maximum MCPD for NTM-LD increased microbiological cure and reduced 3-year mortality by 71 % compared with low MCPD group. Maintaining NTM-LD treatment integrity as possible might positively impact disease outcomes. Sat, 01 Mar 2025 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/12235 2025-03-01T00:00:00Z