http://localhost:8080/xmlui/handle/123456789/7812 Thu, 09 Apr 2026 03:48:04 GMT 2026-04-09T03:48:04Z http://localhost:8080/xmlui/handle/123456789/9342 Title: In vitro Wound Healing Potential and Antimicrobial Activity of Clerodendrum Inerme Leave Extracts Authors: Wisessombat, Sueptrakool; Tayeh, Malatee Abstract: Background: Clerodendrum inerme is a medicinal plant which exhibited many pharmacological effects. However, wound healing property of this plant has not been investigated. Objective: The present study was designed to evaluate wound healing and antimicrobial activities of C. inerme leaves using the in vitro model with Human keratinocytes (HaCaT). Methods: Cytotoxicity and wound healing effects were determined by MTT and scratch wound healing assay. Antimicrobial activities against cutaneous flora and clinical isolates of bacteria were investigated by broth microdilution assay. Results: The results showed that the water extract of C. inerme leaves did not exhibit cytotoxic effects on HaCaT cells, while ethanol extracts at higher concentrations significantly decreased cell growth with an IC50 value of 386.8 ± 87.1 μg/mL. The water extract and the lowest concentration (6.25 μg/mL) of the ethanol extract significantly increased percentage of wound closure compared with the untreated group. The water and ethanol extracts of C. inerme displayed a broad spectrum of antibacterial activity, inhibiting growth of Staphylococcus aureus, Staphylococcus.epidermidis, Escherichia coli, and Pseudomonas aeruginosa. The water extract displayed remarkable activity against methicillin-resistant S. aureus with MIC and MBC values ranging from 0.39 to 1.56 μg/mL. Notably, it provided stronger antibacterial activity than vancomycin and also showed antifungal activity against C. albicans. Conclusion: This study confirms the potential of C. inerme leaves for wound healing and antimicrobial therapy and supports the continued utilization of C. inerme leaves in traditional medicine. Further studies are needed to clarify the molecular mechanisms through which it exerts such biological effects. Key words: Antimicrobial activity, Clerodendrum inerme, Keratinocytes, Scratch assay, Wound healing. Fri, 01 Jan 2021 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/9342 2021-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/9341 Title: Phytochemistry and Pharmacological Activities of Boehmeria Genus: An Update Review Authors: Ikhlas Arsul, Muhammad; Insanu, Muhamad; Fidrianny, Irda Abstract: Introduction: Boehmeria is a genus that has the potential to be natural medicine and also has benefit in industry. This genus consists of 82 plants that includes numerous species, subspecies, and varieties. The objective of this review is to provide an overview of chemical and pharmacological characteristics of Boehmeria genus based on research studies. Methods: The reference articles have DOI and were obtained through database from such as Science Direct and PubMed website to ensure their validity and reliable contents. This literature study was made by using minimum 50 literatures from the last 10 years. Results: There are 16 species of Boehmeria genus confirmed to have chemical compounds, and 9 species of which reported to exhibit pharmacological activity in the form of extracts and single compound isolates. Conclusion: Based on this study, it was known that some Boehmeria species contained abundance of Boehmeriasin A, boehmeriasin B, chlorogenic acid, epicatechin, (Z)-9,10,11-trihydroxy-12 octadecenoic acid, catechin, β-sitosterol, rutin, luteolin-7-glucoside, naringin and hesperidin. Boehmeria genus had various activities such as anticancer, anti-inflammatory, antidiabetic, antihyperlipidemic, antimicrobial, antioxidant, and anti-hepatitis B. Key words: Boehmeria, Chemical compound, Biological activities, Anticancer, Boehmeriasin Fri, 01 Jan 2021 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/9341 2021-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/9338 Title: Modeling relation between hospital efficiency and customer satisfaction of tertiary hospitals: A case of data envelopment analysis Authors: Chandra Akula, Suresh; Singh, Pritpal Abstract: In the present circumstance, it has turned out to be difficult for hospitals to guarantee increasingly productive methods for administrations. Under the current conditions, it is fundamental to discover the fitting asset blend and its use. So also, it is important to distinguish the sources of relative cost wastefulness – specialized and allocated both. The center point of this study is on surveying the hospitals in efficiency terms, for example, the perfect measure of inputs to deliver a given degree of output. The other inspiration driving this investigation has been to see how to address an issue of benchmarking in hospitals. Data envelopment analysis utilizes an amazing procedure of linear programming to help in doing this. The research of the study incorporates two different aspects one is to evaluate efficiency of hospitals considered for study and another is find satisfaction level of patients from these hospitals to find association among both these dimensions, Moreover, this study gives the proof that medical hospital size has a critical negative impact on efficiency of hospital i.e. Present research indicates that smaller hospitals have a higher level of efficiency than larger and medium-size hospitals, smaller size hospitals average efficiency is .80. The average efficiency of medium size hospitals is .75 and the large hospital is .71. Results of research also explains that efficiency is considered to be negative moderator between relation of number of specialized doctors and patient satisfaction. Results of study suggested that higher level of efficiency level of hospitals lessen the positive effect of specialized doctors on patient satisfaction. Key words: Hospital efficiency, Customer satisfaction, Negative moderator, Association. Fri, 01 Jan 2021 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/9338 2021-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/9335 Title: Compound Analysis and Genetic Study of Selected Plectranthus scutellarioides Varieties from Indonesia Authors: Dwi Astuti, Ayun; Iwan Perdana, Awaluddin; Natzir, Rosdiana; Nasrum Massi, Muhammad; Subehan, Subehan; Alam, Gemini Abstract: Background: Plectranthus scutellarioides is one of medicinal plants in Indonesia, which has several hundred varieties but only one is known by local people as medicine. Objective: Six varieties of Plectranthus scutellarioides were analyzed for their total flavonoid content, chemical compound, and moleculer genetic. Methods: TFCs were analyzed using AlCl3 colorimetric method, chemical compounds were identified using TLC-scanning densitometer, GC-MS, and FTIR, moleculer genetic were observed using DNA barcoding rbcL gene. Results: The TFCs of trailing psycholeus, and flamingo varieties were higher than the other varieties. TLC-scanner densitometer showed that color blaze dark star, trailing psycholeus, and trailing queen had similar profiles, as did beale street, trailing rose, and flamingo. The GCMS results showed notable difference in trailing psycholeus and trailing queen which have 2-oleoylglycerol and 9(E),11(E)-conjugated linoleic acid in larger amounts than others, respectively. Multivariate analysis of the FTIR spectra showed the closeness of all varieties, except for beale street which had the lowest similarity with the others. Despite that, genetic studies using the rbcL gene and comparing the results with the P. scutellarioides gene in the database (MW538954.1) showed beale street was the most similar (99.52%). The phylogenetic analysis showed that beale street and trailing psycholeus have the highest similarity among others. Conclusions: There is a slight difference in chemical composition between varieties as well as the genetic. Therefore, quality control or standardisation is needed in the use of this plant as a traditional medicine. Key words: Coleus scutellarioides, Densitometer, Flavonoid, FTIR, GC-MS, rbcL. Fri, 01 Jan 2021 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/9335 2021-01-01T00:00:00Z