http://localhost:8080/xmlui/handle/123456789/7581 Thu, 09 Apr 2026 05:12:25 GMT 2026-04-09T05:12:25Z http://localhost:8080/xmlui/handle/123456789/7624 Title: Molecular Docking and QSAR Study of 5-O-acylpinostrobin Derivatives as Topoisomerase IIα Inhibitors Authors: Rahmah, Siti; Widiandani, Tri; Ekowati, Juni; Adi Priatna, Puja Abstract: Abstract Background: Cancer is one of the top causes of death worldwide. A wide range of illnesses known as cancer can start in almost any organ or tissue in the body when abnormal cells multiply uncontrollably. Cancer patients have higher levels of the Topo IIα protein in their cells, this protein has been proposed as a relevant target for anticancer treatment development. Objective: This study aims to predict the anticancer activity of pinostrobin and 5-Oacylpinostrobin derivatives against topoisomerase IIα by docking molecular and QSAR study. Methods: In silico analysis was performed using the structure of the topoisomerase IIα (PDB: 5GWK)) as templates. Molecular docking analysis was performed with AutoDock Vina. Result: All 5-O-acyl pinostrobin derivatives, showed lower ΔG values than the parent pinostrobin. The 5-O-acetyl pinostrobin compound showed the highest score, namely - 9.14 kcal/mol. 5-O-acetyl pinostrobin is predicted as the most powerful inhibitor that can cause inhibition of topoisomerase IIα. Conclution: The results of the best QSAR equation obtained can be used as a reference for predicting the activity of the new pinostrobin derivatives to be synthesized by inserting the electronic (Etot) parameter values of the compounds into the equation. Keywords: modification, pinostrobin, QSAR, topoisomerase IIα Thu, 07 Mar 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/7624 2024-03-07T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7623 Title: Identification of Drug Related Problems (DRPs) in Rheumatoid Arthritis Patients at Palembang City Hospital Authors: Niza, Hairun; Hanifah Az-Zahra Anwar, Sarah; Merinda, Sintya Abstract: Abstract Background: Rheumatoid arthritis is a chronic systemic inflammatory arthritis disease that affects mainly synovial joints. The incident of RA can lead to the emergence of complications or comorbidities, which then allows patients to receive a variety of therapies that can trigger the incidence of DRPs during the treatment. The prevalence of RA in Indonesia itself in 2018 has reached 7.30%, with the highest percentage occurring in the elderly age group and more prevalent in women. Objective: This study aimed to determine the incidence of DRPs in RA patients in Palembang city hospitals based on the category of DRPs identified as related to drug selection and dose selection problems, as the relationship between demographic factors and the incidence of DRPs. Methods: This research is non-experimental study conducted with a retrospective cross-sectional survey. Data collection was carried out by looking at patient medical record data at X and Y Hospital in Palembang from January 2021 to March 2023. Results: The results showed that the most frequent drps in the drug selection category were drug interactions (72.03%), while in the dose selection category were insufficient dosage regimens (60.74%). The results of bivariate analysis between the incidence of DRPs and gender (p=0.809), age (p=0.879), the number of drugs used (p=0.001), and comorbidities (p=0.089). Conclusion: There is no relationship between demographic factors and comorbidities with the incidence of DRPs, and there is a relationship between the number of drugs and the incidence of DRPs. Keywords: drugs, drug-related problems, drug selection, dose selection, Rheumatoid arthritis Fri, 19 Apr 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/7623 2024-04-19T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7618 Title: The Effect of Education on Writing Integrated Patient Progress Notes (IPPNs) at Several Government Hospitals in Bukittinggi, Indonesia Authors: Serdiani, Serdiani; Nasif, Hansen; Oktavia Sari, Yelly Abstract: Abstract Background: The writing of Integrated Patient Progress Notes (IPPNs) by pharmacists generally does not fulfil the correct writing standards. Objective: This study aimed to analyze the effect of education on the level of knowledge and writing profile of IPPN. Methods: A prospective analytic method research design was used with data collection techniques through questionnaires and total sampling for IPPN data. The researcher developed a valid and reliable questionnaire to measure pharmacists' level of knowledge. Education was conducted through "Focus Group Discussion" with PowerPoint slides of SOAP method writing material and SOAP framework leaflets. Quantitative analysis of IPPN data was performed using the Wilcoxon test on SPSS. Results: The results showed that the highest percentage of pharmacists' knowledge level before education was A.M Hospital (87%) and after education was B Hospital (95%). The profile of IPPN writing by pharmacists before being given education showed the highest percentage of IPPN writing suitability was at A.M Hospital (21.6%), and the completeness of IPPN writing was at M.H Hospital (99%). After education, the highest percentage of IPPNs writing suitability was in B Hospital (64.3%), and the completeness of IPPNs writing was in M.H Hospital (97.9%). Education has an effect on pharmacists' knowledge level (p-value 0.029) and the appropriateness profile of IPPN writing (p-value 0.013). However, education did not affect the completeness of writing Integrated Patient Progress Notes (IPPNs) (p-value 0.285). Conclusion: Education succeeded in improving pharmacists' knowledge of writing CPPT correctly. Keywords: educational impact, integrated patient progress notes (IPPNs), IPPNs writing profil, SOAP notes Thu, 25 Apr 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/7618 2024-04-25T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7616 Title: Cost-Consequence Analysis of Levofloxacin Compared to Ceftriaxone in Community-Acquired Pneumonia of Adult Inpatients at X Hospital Surakarta Authors: Rahardjoputro, Rolando; Wardhana Amrullah, Adhi; Santoso, Joko; Ardya Crisdian Saraswati, Hanugrah; Ernawati, Ernawati; Puji Astuti, Hutari; Silvy Irdianty, Mellia; Nur Fitriana, Rufaida Abstract: Abstract Background: Community-acquired pneumonia is still a significant cost-burden disease in healthcare facilities. Pharmacoeconomic analysis using the cost-consequence analysis (CCA) method of ceftriaxone compared to levofloxacin as a first-line empirical antibiotic has never been carried out. Objective: to model the clinical and economic impact of administering ceftriaxone as a first-line empirical antibiotic compared to its comparator levofloxacin for community-acquired pneumonia therapy in hospitalized adult inpatients from the perspective of healthcare facilities. Methods: This research is a retrospective observational study that collects medical records and patient billing data in X Hospital Surakarta from January to December 2022 period. The study was conducted from June to July 2023. Subjects were adult inpatients aged ≥ 18 years with community-acquired pneumonia and were given levofloxacin or ceftriaxone as first-line empiric antibiotics. The data taken included patient profile, antibiotic effectiveness and direct medical costs. Cost-consequence analysis (CCA) was used to compare levofloxacin to ceftriaxone to assess their impact on length of stay, antibiotic effectiveness, and direct medical costs based on a healthcare perspective. Results: The antibiotic effectiveness for levofloxacin was 75.00%, and ceftriaxone was 93.33%. The average length of stay for levofloxacin was 3.39 days, and ceftriaxone was 3.00 days. The total direct medical costs for levofloxacin were IDR 2,056,799, and ceftriaxone was IDR 1,969,627. Conclusion: The administration of ceftriaxone to levofloxacin as a first-line empirical antibiotic for communityacquired pneumonia in hospitalized adult patients had the consequence of increasing antibiotic effectiveness, reducing the length of stay and saving total direct medical costs by IDR 87,172. Keywords: ceftriaxone, community-acquired pneumonia, cost-consequence, levofloxacin Wed, 24 Apr 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/7616 2024-04-24T00:00:00Z