http://localhost:8080/xmlui/handle/123456789/7388 Tue, 14 Apr 2026 20:24:54 GMT 2026-04-14T20:24:54Z http://localhost:8080/xmlui/handle/123456789/7520 Title: Graptophyllum pictum (L.) Griff. (Syn: Justicia picta Linn.) and its Effectiveness: A Well-Known Indonesian Plant Authors: Makkiyah, Feda; Rahmi, Eldiza Puji; Revina, Rika; Susantiningsih, Tiwuk Abstract: Graptophyllum pictum (L.) Griff., a shrubby stove plant, has been used traditionally to treat various diseases. This review summarizes the up-to-date data about its phytochemistry and pharmacological properties and provides a perspective and direction for future research. The phytochemical analysis of G. pictum revealed the presence of flavonoids, steroids, glycoside, tannins, saponin, chlorophyll, nontoxic alkaloid, and anthocyanin. Meanwhile, the pharmacological analysis revealed that this plant possessed various activities such as antimicrobial, immunomodulatory, antioxidant, anti-inflammation, anti-analgetic, woundhealing, anti-hemorrhoid, anti-diabetic, and estrogenic effects. However, most of its pharmacological activities were based on the crude extracts and the bioactive compounds responsible for the bioactivities have not been well identified. A further detailed investigation in phytochemistry to identify the bioactive compounds and to investigate the mechanism action of its bioactivities is required. Moreover, a toxicology study is also needed to develop a standardized formulation of G. pictum preparation and to fulfill the requirements of modern phytomedicine. Sat, 01 May 2021 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/7520 2021-05-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7518 Title: Inotropes in Chronic Beta-Blocker Therapy Authors: Alsagaff, Mochamad Yusuf; Susanti, Melly; Thaha, Mochammad; Jonatan, Christian Abstract: The increasing rate of cardiovascular disorders contributes to rising hospitalized patients receive chronic oral beta-blocker therapy. Beta-blockers remain one of the fundamental therapy for chronic heart failure. Still, their role in decompensated heart failure and severe sepsis during hospitalization is often debated and inconsistent in clinical practice. In recent years, evidence of the efficacy and clinical outcomes of beta-blockers in acute heart failure (AHF) have accumulated. Clinical research indicates that chronic beta-blockade withdrawals should be prevented, or as soon as hemodynamic stabilization and euvolemic condition are reached, it should be reinstituted. As a subset of AHF patients with low cardiac output required inotropes, the choice of proper agent is fundamental. Different inotropic agents such as inhibitors of the phosphodiesterase, levosimendan, and dobutamine also their associations with beta-blockers are discussed. Sat, 01 May 2021 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/7518 2021-05-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7515 Title: Peppermint, (Mentha × piperita): Role in Management of Diseases through Modulating Various Biological Activities Authors: Almatroodi, Saleh A.; Alsahli, Mohammed A.; Almatroudi, Ahmad Abstract: Peppermint, (Mentha ×piperita), aromatic perennial herb of the mint family (Lamiaceae). It is a natural hybrid of Mentha spicata and Mentha aquatica and is found wild with its parent species in central as well as southern Europe. It holds various types of ingredients including menthol, menthone and cineol. Menthol, which is extracted from peppermint, play an important role in the inhibition of various types of pathogenesis. Peppermint oil also acts as a mild carminative agent and used for disorder of the large intestines that causes stomach pain. Moreover, experimental studies have confirmed its role in health management through anti-oxidant, antiinflammatory, anti-inflammatory, anti-diabetic, neuroprotection and hepatoprotective effects. its topical application shows relief from cold, muscle pain, and headache. The health promoting role of Peppermint has gained a noteworthy scientific attention, but the exact mechanism of its action still remains not clear. The current review mainly emphases on the pharmalogical effects of peppermint in the inhibition of pathogenesis. The purpose of this review is to provide an overview of peppermint in the management of various types of diseases. Sat, 01 May 2021 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/7515 2021-05-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7514 Title: Fenugreek (Trigonella Foenum-Graecum) and its Active Compounds: A Review of its Effects on Human Health through Modulating Biological Activities Authors: Almatroodi, Saleh A.; Almatroudi, Ahmad; Alsahli, Mohammed A.; Rahmani1, Arshad Husain Abstract: Fenugreek seed are rich sources of various essential compounds and such components shows a significant role in the diseases cure and management through its anti-inflammatory, hepatoprotective, cardioprotective, neuroprotective, immunomodulatory, nephroprotective and anti-microbial activity. Moreover, fenugreek seed is a rich source of antioxidant and such potentiality inhibit the pathogenesis of diseases through free radical scavenging activity. Besides, fenugreek and its active compound shows role in tumour inhibition through modulating various genes activity including induction of apoptosis, tumour suppressor gene and inhibition of tumor necrosis factor. This review comprehensively summarizes the role of fenugreek seeds in health management through modulating various physiological and biochemical activities, along with special emphasis on in vitro and in vivo study. Sat, 01 May 2021 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/7514 2021-05-01T00:00:00Z