http://localhost:8080/xmlui/handle/123456789/7132 Fri, 01 May 2026 11:52:56 GMT 2026-05-01T11:52:56Z http://localhost:8080/xmlui/handle/123456789/8628 Title: Potential of Phaleria macrocarpa Leaves Ethanol Extract to Upregulate the Expression of Caspase-3 in Mouse Distal Colon after Dextran Sodium Sulphate Induction Authors: Kusmardi, Kusmardi; Wiyarta, Elvan; Estuningtyas, Ari; Sahar, Nurhuda; Hanafi Midoen, Yurnadi; Tedjo, Aryo Abstract: Ulcerative colitis (UC) is a part of incurable chronic inflammatory disease that has gained importance over the past few decades. A lot of research has been done to find effective treatments for UC, one of which is herbal medicine. Phaleria macrocarpa (PM), an Indonesian native plant, is thought to be an alternative therapy for UC because of its anti-inflammatory properties. Therefore, in this research, Phaleria macrocarpa Leaves Ethanol Extract (PMLEE) is used to assess its effect on UC by using Caspase-3 as apoptosis marker. PMLEE was made from dried material of PM that undergo maceration. Animals were separated into six groups: normal, negative control, positive control, and PMLEE groups (100, 200, 300 mg/kgBW). PMLEE was then injected to BALB/c mice that have been induced by dextran sodium sulphate (DSS) for 7 consecutive days. DSS is used to model UC in mice colon tissue. All animals were sacrificed and their colons were collected then stained with anti-Caspase-3. The stained sections were subsequently examined with ImageJ based on color intensity which generated H-Score as the results. Based on H-Score of each group, PMLEE 300mg has significantly upregulate the expression of Caspase-3 compare to the negative control (p=0.015). PMLEE also has a tendency to be dose dependent based on the significant difference between PMLEE doses. Therefore, it concludes that PMLEE is able to upregulate the expression of Caspase-3 in colon cells as in this study it was directly proportional. Keywords: Mahkota Dewa, Inflammation, Apoptosis, Ulcerative colitis. Fri, 01 Jan 2021 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/8628 2021-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/8626 Title: Microparticles of Herbal Extracts with Antioxidant Activity Authors: Zulham, Zulham; Wilar, Gofarana; Susilawati, Yasmiwar; Subarnas, Anas; Yohana Chaerunisaa, Anis Abstract: Plants that have antioxidant content have been shown to have efficacy on the body, antioxidants have several drawbacks including being sensitive to environmental factors such as light, heat, pH, and oxygen. Microencapsulation is a method that has several advantages including providing several benefits, namely microparticles formulated to protect the core from the environment, cover up discomfort, maintain volatility or cell survival, separate incompatible substances, protect the body from side effects, and optimize, extend, or target drug effects. The choice of the type of polymer used will determine the characteristics of the microparticles produced, therefore a suitable coating material is needed to produce the microparticles. This review article was made to find out the results of research conducted in the manufacture of microparticles by using polymers which are expected to be useful to provide information on the basis of the selection of polymers and methods of making microparticles produced to maintain the stability of substances that are efficacious as antioxidants. Based on the results of the literature search, microencapsulation is a method used to maintain the stability of antioxidant content that has a therapeutic effect. Key words: Microparticle, Extract, Antioxidant, Polymer Fri, 01 Jan 2021 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/8626 2021-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/8625 Title: Pharmacological Potential of the Stinging Plant Tragia Species: A Review Authors: Narasimhan S, Narasimhan S Abstract: Tragia is well known in the botanical world a stinging plants. Apart from this, the genus also occupies an important constituent of alternative systems of medicine as well as ethnobotany. Among the various species of Tragia, the most studied and experimented species is T. involucrata. This genus is used for several ethnobotanical uses such as cancer, diarrhea, constipation, scorpion bite, rheumatism, whooping cough and diabetes. Apart from this the genus is also an important constituent of ayurvedic and siddha medicines. Owing to these properties several researches has been conducted to validate the traditional uses, finding out new uses and understanding the phytochemical profile. Alkaloids, phenols, terpenoids and tannin are present in the genus Tragia. Calcium oxalate and shellsol is responsible for the stinging property. Various species of Tragia has been validated for its important properties such as antibacterial, antifungal, cytotoxic, wound healing and anti-inflammatory activities. All these properties has been related to the occurrence of secondary metabolites. However the exact lead metabolite for the pharmacological properties has to be identified. Based the experimentally proved pharmacological properties, Tragia possesses significant potential on a medicinal species. Key words: Alkaloids, Antibacterial, Tragia, Nanoparticles, Phytochemistry, Pharmacological activities Fri, 01 Jan 2021 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/8625 2021-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/8624 Title: Medicinal Value of Three Agricultural Weed Species of the Asteraceae Family: A Review Authors: Jayasundera, Mithila Abstract: Ageratum conyzoides L., Tridax procumbens L. and Bidens pilosa L. are well known plant species of the Asteraceae family that are considered weeds in intensive agriculture. These weeds are traditionally known to have medicinal properties and have been used for therapeutic treatments. However, it is only the lack of proper knowledge, awareness and screening that have limited their use in pharmaceutical sectors. This review attempts to consolidate the traditional, phytochemical and pharmacological studies that have been carried out on Ageratum conyzoides L., Tridax procumbens L. and Bidens pilosa L., which we note are widely spread throughout the world. This study was conducted through a coherent search on Ageratum conyzoides L., Tridax procumbens L. and Bidens pilosa L. with respect to traditional uses, phytochemical and pharmacological studies that have been performed on these three agricultural weeds all over the world. An exploration of reported descriptions of the potential medical importance of three agricultural weed species (A. conyzoides, T. procumbens and B. pilosa) has been presented. The present review would encourage further clinical investigations into these three plants and their extracts to more closely define the range of uses of these herbs for clinical applications. This, in turn, would give a clear understanding whether these weed species might be targeted to be conserved in a sustainable manner rather than eradicated. Key Words: Ageratum conyzoides, Tridax procumbens, Bidens pilosa, Traditional use, Phytochemical, Pharmacological Fri, 01 Jan 2021 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/8624 2021-01-01T00:00:00Z