DSpace Collection:

The Relationship of Drug Therapy Problems and Outcome Therapy in Tuberculosis Patients in Surabaya Health Center

Mon, 30 Sep 2024 00:00:00 GMT

Title: The Relationship of Drug Therapy Problems and Outcome Therapy in Tuberculosis Patients in Surabaya Health Center Authors: Wijaya, Nyoman; Andini Nathaneila, Luthfia; Priyandani, Yuni Abstract: ABSTRACT Background:Tuberculosis (TB) is a highly contagious disease and is difficult to eradicate in Indonesia. Indonesia ranks second in the number of TB sufferers in the world. Generally, TB patients use more than two types of drug therapy, it can affect the drug therapy problems that arise and can affect the success of treatment.Objectives:This study aims to see the effect of the number of drugs used by TB patients on the number of drug therapy problems (DTP) and therapy outcomes in tuberculosis patients.Methods:This study was a cross-sectional study with purposive sampling conducted at health centers in the Surabaya area in January-June 2024. The sample inclusion criteria included pulmonary tuberculosis patients who had undergone treatment for over one month, were at least 17 years old, and could communicate well using a guided interview method.Results: The results showed that out of 110 patients, 30.0% used 4 types of drugs and 30.0% had two DTPs. Spearman's correlation test between the number of drugs and the number of DTPs with a p-value = 0.000 and a correlation coefficient of 0.472. Spearman's correlation test between the number of DTPs and therapy results with a p-value = 0.430 and a correlation coefficient of -0.076.Conclusion:From this study, it can be concluded that there is a significant relationship between the number of drugs and the number of DTPsin TB patients and there is no relationship between DTP and the results of therapy in TB patients.Therefore, pharmacists at health centers need to keep helping patients understand how to follow their TB treatment correctly, including the right dose, timing, intervals, and length of the treatment.Keywords: DTPs; Health centers; Outcome therapy; Tuberculosis

Profile of Dermatologic Side Effects of Tyrosine Kinase Inhibitor (EGFR-TKIs) in Lung Cancer Patients

Mon, 30 Sep 2024 00:00:00 GMT

Title: Profile of Dermatologic Side Effects of Tyrosine Kinase Inhibitor (EGFR-TKIs) in Lung Cancer Patients Authors: Napitupulu, Elfrida; Nurrochmad, Arief; Riswahyudi Hanafi, Arif; Tri Wahyudi, Danang Abstract: ABSTRACT Background:Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR-TKIs) drugs are commonly used target therapies in patients with advanced-stage non-small cell carcinoma lung cancer (NSCLC).Objectives:This study aims to provide an overview of dermatologic side effects and quality of life index of NSCLC patients who received EGFR-TKIs targeted therapy at Dharmais Cancer Hospital.Methods: This study used a cross-sectional design. Inclusion criteria were patients who received EGFR-TKIs targeted therapy, namely gefitinib, erlotinib, and afatinib, in September -October 2023, who were willing to be research subjects, and patients who were not in a medical emergency. In total, 52 patients filled out the dermatology life quality index (DLQI) questionnaire throughinterviews and medical records. Data evaluation was performed descriptively in the form of percentages.Results: The most common occurrence of dermatologic side effects was skin hypersensitivity reactions with mild severity (grade 1) by 59.6%, moderate severity (grade 2) by 19.2%, and severe severity (grade 3) by 1.9%,and no drug dermatologic side effects by 19.2%. In comparison, the most DLQI was in the category of not affecting patient life. In general, side effects with moderate (grade 2) and severe (grade 3). The severity will decrease to mild severity (grade 1) when already getting topical corticosteroid drugs or combinations with oral antibiotics and antihistamine drugs.Conclusion:The most severe side effect was grade 1, which slightly affected the patient's quality of life. Education and monitoring of side effects and management of symptoms are necessary to reduce the severity and improve patients' quality of life.Keywords: Dermatologic side effects; DLQI; EGFR-TKIs; Non-small cell lung cancer(NSCLC)

Community Knowledge, Attitude and Practice toward Self-Medication and Its Influencing Factor in Central Java: A Cross-Sectional Study

Mon, 30 Sep 2024 00:00:00 GMT

Title: Community Knowledge, Attitude and Practice toward Self-Medication and Its Influencing Factor in Central Java: A Cross-Sectional Study Authors: Yulianti, Tri; Fitri Muazizah, Anisa Abstract: ABSTRACT Background:Self-medication refers to people selecting and using medications to treat self-identified diseases or symptoms. Self-medication practices vary between communities and are impacted by a variety of factors. Understanding self-medication knowledge, attitude, and practice is essential to minimize risks and negative consequences. Objectives:This study aims to analyze the community's knowledge, attitude, and practice (KAP) concerning self-medication and the factors that influence it.Methods: A cross-sectional study was undertaken among the general community in Central Java, Indonesia. In this study, 396 participants were recruited and interviewed using a validated Knowledge, Attitudes, and Practices questionnaire focused on self-medication. The sociodemographic variables and levels of knowledge, attitudes, and practices were represented using descriptive statistics in the statistical analysis. Bivariate and multivariable logistic regression analysis tests were employed to determine therelationship between socio-demographic characteristics and levels of knowledge, attitudes, and practices. Results: The results showed that the age group of 36-45 years had the most significant percentage of participation, with 103 individuals. The sample consisted of 235 females, 59.3% of the total participants. Respondents had a sufficient level of knowledge (39.6%), good attitudes (51.8%), and good practice (75%).Conclusion:There was a significant correlation between age, education, and income regarding the knowledge around self-medication with a p-value <0.05. There also remained a significant correlation between knowledge, attitude, and practice.Keywords: attitude; knowledge;self-medication; practice

Knowledge, Attitudes, and Practices in Bungkulan Buleleng Village Communities Related to the Implementation of COVID-19 Vaccination

Mon, 30 Sep 2024 00:00:00 GMT

Title: Knowledge, Attitudes, and Practices in Bungkulan Buleleng Village Communities Related to the Implementation of COVID-19 Vaccination Authors: Nila Yuliawati, Agustina; Made Dwi Andika, Dewa Abstract: ABSTRACT Background:The contribution of the community through their knowledge, attitudes, and practices are essential to control COVID-19 through vaccination.Objectives:This study aims to analyze the relationship between knowledge, attitudes, and practicesof the community related to implementing the COVID-19 vaccine.Methods: This observational study with a cross-sectional design was carried out from June to July 2023. Samples of 155 respondents were obtained through convenience sampling. Inclusion criteria include the community domiciled in Bungkulan Village, aged ≥18 years, and is willing to be involved in research, while respondents who didn’t fill in the complete questionnaire are excluded from research. Data was collected using self-developed offline questionnaire. The relationship of knowledge, attitudes, and practices was analyzed by multiple linier regression and Spearman-rho test (95% CI).Results: Findings showed that the majority of respondents were aged 25-29 years old (30.32%), male (76.13%), graduated from high school (65.16%), worked (89.68%), didn’t experience comorbidities (96.13%) and AESI(87.10%), lack of knowledge (53.29 ± 23.24) but has a goodattitude (75.18 ± 11.55)and practices(84.06 ± 16.17) related to the implementation of the COVID-19 vaccination. There is a significant relationship between knowledge with attitudes (r = 0.352; p = <0.001) and attitudes with practices (r = 0.257; p= <0.001), also knowledge and attitudes simultaneously influence the practice of Covid-19 vaccination(p=<0.001).Conclusion:A person's attitudes and practices in a positive direction tend to begin with good knowledge. Strong sources of public health information and communication are necessary to develop good knowledge.Keywords: attitudes; COVID-19; knowledge; practices; vaccination