http://localhost:8080/xmlui/handle/123456789/6997 Sat, 11 Apr 2026 16:06:03 GMT 2026-04-11T16:06:03Z http://localhost:8080/xmlui/handle/123456789/7247 Title: Aphrodisiac Activity of Ethanolic Extracts from the Fruits of Three Pepper Plants from Piperaceae Family Authors: Pramesti Wardani, Nindya; Toto Poernomo, Achmad; Isnaeni, Isnaeni Abstract: Abstract Background: Exploration of antibacterial substances from new sources such as plants, animals, and microorganisms, both living and symbiotic, is an alternative solution to overcome potential antibacterial needs. Microorganisms in bacteria are targeted as a sustainable source of antibacterial substances because of their ability to propagate easily. Bacteria living in symbiosis are known to produce antibacterial metabolites with a wider spectrum than whole-cell bacteria. They can symbiosis with various living things including multicellular organisms such as sponges. The isolate of Bacillus tequilensis BSMF symbiotic with Halichondria panicea from Cabbiya Madura Coast has been reported to produce antibacterial metabolites. Objective: To determinate the pH and temperature on antibacterial metabolite production from Bacillus tequilensis BSMF symbiotic Halichondria panicea using Potato Dextrose Agar (PDA) media. Methods: The production of the antibacterial metabolites was carried out by solid fermentation method on PDA media with adjusted pH (5 - 8) and temperature (28, 32, 37oC) using Staphylococcus aureus ATCC 25923 and Eschericia coli ATCC 25922 as test bacteria. The antibacterial activity was determined by measuring the inhibition zone diameter. Results: The optimal pH media and incubation temperature Bacillus tequilensis BSMF antibacterial activity against Staphylococcus aureus ATCC 25923 and Eschericia coli ATCC 25922 were 8 ± 0.5 and 32 ± 1 oC respectively. The average antibacterial activity index against the test bacteria were 2.74 ± 0.07 and 3.39 ± 0.07 respectively. Conclusion: The production of antibacterial metabolites from Bacillus tequilensis BSMF could be performed optimally at pH 8 ± 0.5 and 32 ± 1 oC. Keywords: antibacterial metabolites, Bacillus tequilensis BSMF, Halichondria panicea, pH, temperature Sun, 29 Aug 2021 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/7247 2021-08-29T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7246 Title: Optimasi Kondisi Fermentasi pada Produksi Metabolit Antibakteri dari Bacillus tequilensis BSMF Simbiotik Halichondria panicea Authors: Pramesti Wardani, Nindya; Toto Poernomo, Achmad; Isnaeni, Isnaeni Abstract: Abstract Background: Exploration of antibacterial substances from new sources such as plants, animals, and microorganisms, both living and symbiotic, is an alternative solution to overcome potential antibacterial needs. Microorganisms in bacteria are targeted as a sustainable source of antibacterial substances because of their ability to propagate easily. Bacteria living in symbiosis are known to produce antibacterial metabolites with a wider spectrum than whole-cell bacteria. They can symbiosis with various living things including multicellular organisms such as sponges. The isolate of Bacillus tequilensis BSMF symbiotic with Halichondria panicea from Cabbiya Madura Coast has been reported to produce antibacterial metabolites. Objective: To determinate the pH and temperature on antibacterial metabolite production from Bacillus tequilensis BSMF symbiotic Halichondria panicea using Potato Dextrose Agar (PDA) media. Methods: The production of the antibacterial metabolites was carried out by solid fermentation method on PDA media with adjusted pH (5 - 8) and temperature (28, 32, 37oC) using Staphylococcus aureus ATCC 25923 and Eschericia coli ATCC 25922 as test bacteria. The antibacterial activity was determined by measuring the inhibition zone diameter. Results: The optimal pH media and incubation temperature Bacillus tequilensis BSMF antibacterial activity against Staphylococcus aureus ATCC 25923 and Eschericia coli ATCC 25922 were 8 ± 0.5 and 32 ± 1 oC respectively. The average antibacterial activity index against the test bacteria were 2.74 ± 0.07 and 3.39 ± 0.07 respectively. Conclusion: The production of antibacterial metabolites from Bacillus tequilensis BSMF could be performed optimally at pH 8 ± 0.5 and 32 ± 1 oC. Keywords: antibacterial metabolites, Bacillus tequilensis BSMF, Halichondria panicea, pH, temperature Sun, 29 Aug 2021 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/7246 2021-08-29T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7245 Title: Karakteristik dan Stabilitas Fisik NLC-Koenzim Q10 dalam Sleeping Mask dengan Minyak Nilam Authors: Dita Mayangsari, Fransisca; Erawati, Tristiana; Soeratri, Widji; Rosita, Noorma Abstract: Abstract Introduction: patchouli oil has an antioxidant and penetration-enhancing effect. The oil potentially increased the effectiveness of sleeping mask with Coenzyme Q10 (CoQ10) in Nanostructured Lipid Carriers (NLC) as an antiaging cosmetic. Objective: To observed the physical characteristics and stability of NLC-CoQ10 in sleeping masks compared to NLC-CoQ10 in sleeping masks with 1% patchouli oil. Methods: The preparation of NLC-CoQ10 was using the High Shear Homogenization method. NLC-CoQ10 was mix with hydrogel and patchouli oil for F2. While for F1 without patchouli oil. After that, physical characteristics and stability were observed, included organoleptic, pH, and viscosity. Physical stability test observed at room temperature for 90 days. Results: The physical characteristics test showed that F1 had an odor like oleum cacao, while F2 had a specific odor of patchouli oil and a slight odor like oleum cacao. F1 had 6.036 ± 0.011 for pH value, while F2 had 6.062 ± 0.020. There is no significant difference. However, F1 and F2 have different viscosity values. F1 had 199.2 ± 0.7 cp for viscosity value, while F2 had 175.6 ± 7.9 cp. The physical stability test showed that F1 and F2 had pH value scale ranges from 6.055 - 6.336 and viscosity 175.6 - 239.7 cp. The viscosity value of F1 had increased after the 60th day, while F2 on the 90th day. Conclusion: Based on characteristic and physical stability tests can be concluded that F1 and F2 have different odor and viscosity, and F2 is more stable than F1. Keywords: sleeping mask, nanostructured lipid carriers (NLC), coenzyme Q10, patchouli oil Sun, 29 Aug 2021 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/7245 2021-08-29T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7244 Title: Optimasi Aristoflex®️ AVC dan Propilen Glikol Gel Tabir Surya Rimpang Kunyit dengan Metode Desain Faktorial Authors: Sumule, Arsiaty; Pamudji1, Gunawan; Diyah Ikasar, Endang Abstract: Abstract Background: Turmeric (Curcuma domestica) contains curcumin suitable for use as a skin protector from ultraviolet (UV). Topical sunscreens need to be developed, which is a gel, the most stable preparation. Optimization is more profitable than trial and error methods in terms of cost, time, and accuracy of results. Objective: To determine the effect of combining Aristoflex® AVC and propylene glycol on the physical properties of turmeric rhizome extract gel, as well as the optimum turmeric rhizome extract gel formula and the effect of combining Aristoflex® AVC and propylene glycol on the SPF value of turmeric rhizome extract gel. Methods: Gel had been made into four formulas with the composition of Aristoflex® AVC 1% and 3% and propylene glycol 5% and 10%. The parameters were spreadability, adhesion, viscosity, and SPF values calculated in vitro using spectrophotometer. The results had been optimized by factorial design using Design Expert 7.1.5. Results: The combination of Aristoflex® AVC and propylene glycol had affected spreadability, adhesion, viscosity, and SPF value. The results had shown that the optimum formula of turmeric rhizome extract gel in the combination of Aristoflex® AVC and propylene glycol 1.68% and 9,87% respectively, so that the spreadability was 5.1 cm, adhesion was 2.018 seconds, viscosity was 110.008 dPas, and SPF value was 11.935. Conclusion: Combination of Aristoflex® AVC and propylene glycol affected on the spreadability, adhesion, viscosity, and SPF value of the turmeric rhizome extract gel. The proportion of Aristoflex® AVC 1.68% and propylene glycol 9.87% was the optimum formula. Keywords: aristoflex® AVC, gel, propylene glycol, turmeric, sunscreen Sun, 29 Aug 2021 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/7244 2021-08-29T00:00:00Z