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Validitas dan Reliabilitas Kuesioner Kepatuhan Pengobatan Pasien Lansia dengan Hipertensi berdasarkan Teori Health Belief Model

Thu, 01 Apr 2021 00:00:00 GMT

Title: Validitas dan Reliabilitas Kuesioner Kepatuhan Pengobatan Pasien Lansia dengan Hipertensi berdasarkan Teori Health Belief Model Authors: Rusmadi, Nurhidayati; Pristianty, Liza; Zairina, Elida Abstract: sed on the Health Belief Model (HBM) theory. The questionnaire was developed based on a review of the literature and discussions with experts. The questionnaire consists of six dimensions to measure HBM: perceived susceptibility, perceived severity, perceived benefits, perceived barriers, self-efficacy, and cues to action. The study included 30 participants aged 60-79 years who had taken captopril or amlodipine in the previous three months. The validity test results showed that of the 45 question items in the questionnaire, eight items were invalid, and 37 others were demonstrated valid based on the Pearson Correlation value (> r table 0.361; p <0.05). Furthermore, each domain in 37 valid items were tested for reliability at a significance level of 0.05, and the results showed that each size had a Cronbach's Alpha value >0.7, with an overall score was 0.927, indicating that all domains in the questionnaire were reliable. To summarize, the HBM theory-based questionnaire is a valid and reliable instrument for assessing medication adherence in the elderly with hypertension.

Uji Aktivitas Antioksidan dan Daya Hambat Enzim Tirosinase Ekstrak Etanol Azolla filiculoides Lam

Thu, 01 Apr 2021 00:00:00 GMT

Title: Uji Aktivitas Antioksidan dan Daya Hambat Enzim Tirosinase Ekstrak Etanol Azolla filiculoides Lam Authors: Prasetyo, Bayu Febram Abstract: Azolla (Azolla filiculoides Lam.) is an aquatic fern of the Salviniaceae family. Azolla filiculoides used as natural feed that are abundantly available in nature but have not been optimally utilized. Azolla could be symbiotized with Cyanobacteria. Azolla has bioactive compounds as antioxidants and tyrosinase inhibitors. The purpose of this study was to measure antioxidant activity by DPPH method (2,2-diphenyl-1-picrylhydrazin) and tyrosinase inhibitor from ethanol extract of Azolla filiculoides by ELISA method in vitro with L-tyrosine and L-DOPA (L-3,4-dihydroxyphenylalanine) substrate. Extraction by maceration method and using 96% ethanol as solution. The result of phytochemical analysis showed that azolla extract contains flavonoid, tannins, saponins, steroids and triterpenoids. The phytochemical compounds potentially as antioxidants and tyrosinase inhibitory, particularly flavonoid and tannin compounds. Antioxidant activity assay showed that the ethanol extract of Azolla filiculoides was strong with IC50 23.00 ppm. Tyrosinase inhibitor activity assay showed that tyrosinase inhibition activity on diphenolase activity (IC50 996.60 ppm) more effective than monophenolase activity (IC50 1893.09 ppm).

Profil Kualitas dan Kuantitas Penggunaan Antibiotik Profilaksis pada Pre, On, dan Post Bedah di Rumah Sakit Provinsi (RSP) NTB

Thu, 01 Apr 2021 00:00:00 GMT

Title: Profil Kualitas dan Kuantitas Penggunaan Antibiotik Profilaksis pada Pre, On, dan Post Bedah di Rumah Sakit Provinsi (RSP) NTB Authors: Massey, Firdaus Kabiru; Rika, Yulia; Muliani, Nurlina; Herawati, Fauna Abstract: : This study aims to determine the profile of the quantity of antibiotic use based on the DDD / 100 patient-days method and the quality of antibiotic use based on the percentage of suitability (indication, time of administration, duration, dose, and route of administration) of ASHP Therapeutic Guidelines, Antibiotic Use Guideline (AUG) Hospital, and Hospital Formularium, as well as profiles Surgical Site Infection (SSI) in surgical patients in the West Nusa Tenggara Provincial Hospital (WNT PH) in the January-June 2019 period. This research is an observational study analyzed descriptively with the direction of retrospective data collection using medical record data. The research sample was patients who underwent surgery and met the inclusion criteria, obtained as many as 323 people. The results obtained from this study were the quantity of antibiotic use in the January-June 2019 period dominated by the antibiotic ceftriaxone (J01DD04) with a total DDD / 100 patient-days value in pre-surgery that was 77,655, on surgery 87,31, and post surgery 93,65 . The suitability of prophylactic antibiotic selection based on ASHP guidelines of 1.9%, AUG 15.5%, and Formulary of NTB Provincial Hospital 100%, while the suitability of duration, time of administration, dosage, and route of administration based on ASHP were 19.2%, respectively, 42.7%, 1.5%, and 100%. The research samples that experienced SSI were 2 of 323 samples (0.62%) with the results of bacterial growth namely Proteus sp., Staphylococcus aureus, S. epidermidis, and E.coli. The overall sensitivity test of the bacteria that causes SSI was found to be still sensitive to antibiotics such as chloramphenicol, amoxicillin-clavulanic acid, vancomycin, cefoxitin, and oxacillin. It can be concluded that the use of antibiotics in surgical patients at RSP NTB is entirely in accordance with the applicable formulary, but an update of the existing formulary is needed to follow the development of bacterial sensitivity

Review Neutrophil Gelatinase-Associated Lipocalin (NGAL): Perannya sebagai Biomarker pada Kerusakan Ginjal Akut

Thu, 01 Apr 2021 00:00:00 GMT

Title: Review Neutrophil Gelatinase-Associated Lipocalin (NGAL): Perannya sebagai Biomarker pada Kerusakan Ginjal Akut Authors: Syadiah, Ami Rahmati; Febrina, , Ellin; Levita, Jutti Abstract: Acute kidney injury is a disease that has a high risk of causing critical illness to death and requiring rapid diagnosis in its treatment. Currently, the detection of acute kidney injury is still limited and has not been done specifically to become a fast and precise biomarker standard. Neutrophil gelatinase-related lipocalin (NGAL) is a 25 kDa lipocalin protein found in renal and hepatic epithelial cells. NGAL can respond to damage to renal tubular epithelial cells, crises with NGAL in urine and plasma. The purpose of this review article is to demonstrate that NGAL can be used as a marker for rapid, sensitive, and specific acute kidney injury. The method used in the review of this article uses a search through PubMed®database. The results of the research that have been done show that NGAL can overcome acute kidney injury 2 to 12 hours faster, has a higher sensitivity and specificity than other clinical diagnosis measurement standards. So that NGAL can be used as acute kidney injury quickly, with high sensitivity and specificity.