http://localhost:8080/xmlui/handle/123456789/6778 Thu, 09 Apr 2026 05:11:37 GMT 2026-04-09T05:11:37Z http://localhost:8080/xmlui/handle/123456789/10323 Title: Relationship Between Cephalosporin Use and Increased APTT and PT in Cardiovascular Patients at Government Hospital Bengkulu Authors: Laila Ramatillah, Diana; Purba, Rahelia; Rahima Mahyani, Atika; Hassan Elnaem, Mohamed; Ibrahim, Baharudin; Azhar Syed Sulaiman, Syed Abstract: The interaction that occurs between warfarin and antibiotics is a pharmacokinetic interaction which cause bleeding. This study aims to determine whether there is a relationship between the use of cephalosporins and an increase in APTT and PT in cardiovascular patients. This retrospective observational study employs case-control analysis to examine APTT and PT features in cardiovascular patients receiving single anticoagulant or anticoagulant + cephalosporin therapy for the period July- December 2020. The sampling method used in this study is a convenient sampling method that meets the inclusion and exclusion criteria. Analysis of the data used is Logistic Regression. The study found among 65 male and 15 female, 40 patients used anticoagulant, and another 40 patients used anticoagulant and cephalosporine. Among 40 patients who used combination anticoagulant and cephalosporin, 22 of them had experienced of increasing APTT and PT. Cephalosporins showed a significant correlation with APTT and PT, with a P-value of 0.015. From this study, it can be concluded that the use of cephalosporins increases in APTT and PT values in cardiovascular patients who are given anticoagulant drugs and cephalosporins. Keywords: anticoagulants; APTT and PT; cephalosporins Mon, 01 Jan 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/10323 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/10315 Title: Formulation and Antioxidant Activity Test of Gel from Fermented Red Pomegranate Peel Juice (Punica Granatum L) Authors: Faizatun, Faizatun; Miftahurrohmah, Nur; Eka Sari, Widya; Rosmawati, Rosmawati Abstract: Red pomegranate (Punica granatum L.) peel has secondary metabolites such as phenolics, flavonoids, and tannins, which are known to have antioxidant potential. The purpose of this study was to evaluate the comparison of antioxidant activity of juice before and after fermentation and then formulate it into a gel preparation that is physically and chemically stable. Red pomegranate peel juice was dried by freeze drying method and then fermented with Lactobacillus plantarum ATCC 8014 bacteria and measured OD600, pH, and antioxidant activity using DPPH reagent. The results showed that pomegranate peel juice before fermentation had strong antioxidant activity with a value (of IC50 35.64 ± 0.68 ppm) and after fermentation, it was in the very strong category (IC50 8.00 ± 0.01 to 8.11 ± 0.06 ppm); pH before and after (3.96 ± 0.02 and 3.33 ± 0.01). Formula II with juice concentration of 300 x IC50 has the highest antioxidant activity with IC50 values (64.37 ± 1.13 ppm); pH (6.33); spreadability (6.20 ± 0.07); and viscosity (31333.3 ± 577.35 dPas). There was an increase in antioxidant activity of red pomegranate peel juice after fermentation, the resulting gel is physically and chemically stable based on the results of accelerated stability tests for 4 weeks. Keywords: antioxidant activity; fermentation; Lactobacillus plantarum; pomegranate peel. Mon, 01 Jan 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/10315 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/10314 Title: Synthesis and In Vitro Antimalarial Activity of Amino Chalcone Derivatives Compounds Through Inhibition of Heme Polymerization Authors: Dona, Rahma; Frimayanti, Neni; Hendra, Rudi; Jasril, Jasril Abstract: This study aims to investigate the potential of chalcone derivatives as antimalarial agents. The structure of the chalcone derivatives was designed by inserting amino substituents on acetophenone and methoxy variants on benzaldehyde to produce three amino chalcone derivatives (C1, C2, and C3). The synthesis was carried out by carrying out the Claisen-Schmidt condensation reaction with NaOH 40% as catalyst, resulting in compound yields ranging from 66% - 83%. The structure of the three compounds was determined by FTIR, MS, and 1H-NMR spectroscopy techniques, which confirmed that the compounds had structures that were in line with the desired molecular structure. The antimalarial activity test was carried out by inhibiting the heme polymerization process into hemozoin (β-hematin) using hydroxychloroquine sulfate as a positive control. Absorption measurements were carried out at two different wavelengths, namely 415 nm and 630 nm. The results of the IC50 antimalarial activity of the three compounds (C1, C2, C3) were obtained respectively at 227.61; 115.18; 260.01 μg/mL and positive control of 184.98 μg/mL. From these results, it was found that compound C2 showed better antimalarial activity compared to the other two compounds and positive control. Keywords: amino chalchone; synthesis; antimalarial; heme polymerization; hemozoin. Mon, 01 Jan 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/10314 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/10311 Title: Development of Coffee Fruit Skin (Coffea canephora) Formula as Antioxidant peel-off Masks Authors: Khaira Nursal, Fith; Amalia, Anisa; Nining, Nining; Athaya Putri, Dania; Dara Larasati, Kinanti Abstract: The outer skin of the robusta coffee bean (Coffea canephora) was a processing waste containing phenolic compounds with an antioxidant role. This activity is relevant when used in cosmetic preparations such as peel-off masks, which form a thin elastic layer on the facial surface and are easy to remove. One of the crucial ingredients of peel-off masks is a plasticizer such as sorbitol, characterized by flexibility, not easily fragile, and elasticity. Therefore, this research aimed to develop a peel-off formula from robusta coffee skin by influencing sorbitol variations on the characteristics of masks in the form of a gel. A total of six gel mask formulas were made with sorbitol variations of 10%, 12.5%, and 15%. The two types of gel base used were Carbopol 940 and HPMC (Hydroxy Propyl Methyl Cellulose), at concentrations of 0.25% and 4%, respectively. The results showed that sorbitol variations affected the physical characteristics (p > 0.05) but did not influence the antioxidant activity of robusta coffee skin extract peel-off masks. Keywords: coffe bean skin; peel-off mask; sorbitol; physical characteristics. Mon, 01 Jan 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/10311 2024-01-01T00:00:00Z