http://localhost:8080/xmlui/handle/123456789/4798 1405-2040 Wed, 08 Apr 2026 21:02:05 GMT 2026-04-08T21:02:05Z http://localhost:8080/xmlui/handle/123456789/5115 Title: AnimalModelsofFibrosisinNonalcoholic Steatohepatitis:DoTheyReflectHumanDisease Authors: HIpsen, David; Lykkesfeldt, Jens Abstract: Nonalcoholic steatohepatitis (NASH) is one of the most common chronic liver diseases in the world, yet no pharmacotherapies are available. The lack of translational animal models is a major barrier impeding elucidation of disease mechanisms and drug development. Multiple preclinical models of NASH have been proposed and can broadly be characterized as diet-induced, deficiency-induced, toxin-induced, genetically induced, oracombinationofthese.However,veryfewmodelsdevelopadvancedfibrosiswhilestillreflectinghumandiseaseetiologyorpathology,whichis problematicsincefibrosisstageisconsideredthebestprognosticmarkerinpatientsandanimportantendpointinclinicaltrialsofNASH.Whilemice andratspredominatetheNASHresearch,severalotherspecieshaveemergedaspromisingmodels.Thisreviewcriticallyevaluatesanimalmodels ofNASH,focusingontheirabilitytodevelopadvancedfibrosiswhilemaintainingtheirrelevancetothehumancondition Wed, 01 Jan 2020 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/5115 2020-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/5114 Title: PotentialofGlucagon-LikePeptide1asaRegulator ofImpairedCholesterolMetabolismintheBrain Authors: Kim, Young-Kook; Song, Juhyun Abstract: Cerebral vascular diseases are the most common high-mortality diseases worldwide. Their onset and development are associated with glycemic imbalance, genetic background, alteration of atherosclerotic factors, severe inflammation, and abnormal cholesterol metabolism. Recently, the gut–brainaxishasbeenhighlightedasthekeytothesolutionforcerebralvesseldysfunctioninviewofcholesterolmetabolismandsystemiclipid circulation. In particular, glucagon-like peptide 1 (GLP-1) is a cardinal hormone that regulates blood vessel function and cholesterol homeostasis and acts as a critical messenger between the brain and gut. GLP-1 plays a systemic regulatory role in cholesterol homeostasis and blood vessel function in various organs through blood vessels. Even though GLP-1 has potential in the treatment and prevention of cerebral vascular diseases, the importance of and relation between GLP-1 and cerebral vascular diseases are not fully understood. Herein, we review recent findings on the functionsofGLP-1incerebralbloodvesselsinassociationwithcholesterolmetabolism Wed, 01 Jan 2020 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/5114 2020-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/5113 Title: EcologicalSensingThroughTasteand ChemosensationMediatesInflammation: ABiologicalAnthropologicalApproach Authors: Giuliani, Cristina; Franceschi, Claudio Abstract: Ecologicalsensingandinflammationhaveevolvedtoensureoptimabetweenorganismsurvivalandreproductivesuccessindifferentandchanging environments.Atthemolecularlevel,ecologicalsensingconsistsofmanytypesofreceptorslocatedindifferenttissuesthatorchestrateintegrated responses (immune, neuroendocrine systems) to external and internal stimuli. This review describes emerging data on taste and chemosensory receptors,proposingthemasbroadecologicalsensorsandprovidingevidencethattasteperceptionisshapednotonlyaccordingtosenseepitopes fromnutrientsbutalsoinresponsetohighlydiverseexternalandinternalstimuli.Weapplyabiologicalanthropologicalapproachtoexaminehow ecological sensing has been shaped by these stimuli through human evolution for complex interkingdom communication between a host and pathologicalandsymbioticbacteria,focusingonpopulation-specificgeneticdiversity.Wethenfocusonhowthesesensoryreceptorsplayamajor role in inflammatory processes that form the basis of many modern common metabolic diseases such as obesity, type 2 diabetes, and aging. Theimpactsofhumannicheconstructionandculturalevolutioninshapingenvironmentsaredescribedwithemphasisonconsequentbiological responsiveness. Wed, 01 Jan 2020 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/5113 2020-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/5112 Title: DoubleBurdenofMalnutritionandNutrition TransitioninAsia:ACaseStudyof4Selected CountrieswithDifferentSocioeconomic Development Authors: Gao, Liwang; Bhurtya, Ashok Wed, 01 Jan 2020 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/5112 2020-01-01T00:00:00Z