DSpace Collection: 129 - 253

Corrigendum to “Comprehensive bibliographic study of the framework of complex generic drugs” [J Taibah Univ Med Sci 20 (2) (April 2025) 169e177]

Wed, 01 Jan 2025 00:00:00 GMT

Title: Corrigendum to “Comprehensive bibliographic study of the framework of complex generic drugs” [J Taibah Univ Med Sci 20 (2) (April 2025) 169e177] Authors: Sreedevi, Amatha; Ligade, Virendra S.; Dewan, Shailee

Court-based education as a focal practice to overcome violence against healthcare professionals

Wed, 01 Jan 2025 00:00:00 GMT

Title: Court-based education as a focal practice to overcome violence against healthcare professionals Authors: Khani, Hamed; Eslamitabar, Shahriar

Exploring HPV-linked head and neck cancer in Southern Punjab, Pakistan: Insights from HPV-16 phylogenetic analysis

Wed, 01 Jan 2025 00:00:00 GMT

Title: Exploring HPV-linked head and neck cancer in Southern Punjab, Pakistan: Insights from HPV-16 phylogenetic analysis Authors: Kashif, Muhammad; Minhas, Sadia; Jahan, Shah; dkk. Abstract: Introduction/objectives: Head and neck region squamous cell carcinoma (HNSCC) is a heterogeneous disease that can be categorized into human papillomavirus (HPV)- positive (20 %) and HPV-negative (80 %) subtypes. However, the prevalence of HPV genotypes is not clear in Pakistan. This study investigated how common the HPV- 16 genotype is in patients with HNSCC in the Southern Punjab region of Pakistan, and the specific molecular features of this genotype. Methods: For this cross-sectional study, 85 tissue samples were collected from diagnosed cases of HNSCC. Formalin-fixed paraffin-embedded tissue sections were used for genomic DNA extraction. The L1 region was amplified using GP5þ and GP6þ primers to detect HPV DNA. Real-time PCR was conducted to genotype highrisk HPV (HR-HPV). Whole genome sequencing was used for phylogenetic analysis of HPV-16 and to detect mutations/single nucleotide polymorphisms (SNPs). Results: Among the 85 samples, 7.1 % were positive for HPV, where 4.7 % were positive for HPV-16 and 2.4 % were positive for HPV-18. A significant association was found between HR-HPV positivity and histological grade (p < 0.05). The HPV-16 genome sequence obtained in this study was closely related to those from Thailand, the United States, India, China, and Europe, and 11 mutations/ SNPs were detected in the sequenced genome, where four were novel. Conclusion: The findings obtained in the present study demonstrate the low prevalence of HR-HPV associated HNSCC in Pakistan. Phylogenetic analysis showed that HPV-16 genome isolated and sequenced in this study had a distinct genetic structure and it also shared similarities with genomes reported from Thailand, the United States, India, China, and Europe.

Bullying experience among Nigerian physiotherapists: Prevalence and impact on workplace performance

Wed, 01 Jan 2025 00:00:00 GMT

Title: Bullying experience among Nigerian physiotherapists: Prevalence and impact on workplace performance Authors: Mbada, Chidozie E.; Efunniyi, Adenike O.; Omole, John O.; dkk. Abstract: Objectives: Bullying in physiotherapy education and practice is a significant issue that has received limited attention in the literature. This study assessed the prevalence and impact of bullying experiences on work performance among Nigerian physiotherapists, while also identifying the sociodemographic factors associated with these bullying experiences. Methods: Ninety-seven physiotherapists from six purposively selected federal hospitals in South-West Nigeria participated in this study. An educational pamphlet was initially provided to consenting respondents to clarify the concept of bullying as a psychosocial construct. Subsequently, bullying experiences and their impact on work performance were assessed using validated self administered questionnaires. Data on sociodemographic and work characteristics of the respondents were also collected. Results: The study found a 40.2%prevalence of bullying experiences. Of those affected, 51.3 % experienced vertical bullying, 12.8 % lateral bullying, and 35.9 % both forms. Vertical bullying was primarily perpetrated by chief medical directors (15.8 %), consultants (15.8 %), and medical officers (31.6 %). Bullying experiences were associated with negative work performance (40.2 %) and poor teamwork with other health professionals (61.6 %). There was a significant association between the level of bullying experience and work performance (c2 = 84.718, p = 0.001). Conclusions: Nigerian physiotherapists experience a high prevalence of lateral and vertical bullying, which negatively impacts their work performance and relationships with other healthcare providers. Addressing this issue is crucial for a healthier work environment and better professional interactions.