http://localhost:8080/xmlui/handle/123456789/11792 1077 - 1211 Wed, 08 Apr 2026 23:04:39 GMT 2026-04-08T23:04:39Z http://localhost:8080/xmlui/handle/123456789/11808 Title: Revolutionizing healthcare in KSA: A deep dive into clinical practice guideline development and implementation Authors: Crisera, Vittoriana G.; AlMubarak, Abdulaziz K.; Saeedi, Mohammad Y.; Memish, Ziad A. Abstract: KSA is transforming its healthcare system by developing and implementing Clinical Practice Guidelines (CPGs), a tool designed to improve patient outcomes, standardize care, and facilitate evidence-based decision-making. CPGs are crucial in addressing healthcare disparities, thereby promoting health equity and patient experience. They are integral to KSA’s healthcare transformation agenda. The development process involves topic selection, evidence gathering, and guideline development and dissemination, with the National Centre for Evidence- Based Medicine (NCEBM) responsible for the appraisal and publication of quality CPGs. However, the current guideline landscape faces challenges such as conflicts of interest, lack of key stakeholder groups involved, methodological rigor, and inadequate monitoring as well as feedback loop. In this article, we discuss how we can overcome these issues. For instance, healthcare organizations can provide resources, integrate CPGs into electronic health records (EHRs), and create a culture that values evidence-based practice and continuous quality improvement. Technology plays a pivotal role in the successful implementation of CPGs, with EHRs, telemedicine, and artificial intelligence reshaping healthcare delivery across the globe. Future prospects for healthcare in KSA include the increasing use of technology, patient-centric care, and the adoption of digital healthcare technologies. By embracing innovation, fostering collaboration, and prioritizing patient-centric care, Saudi Arabi is paving the way for a new era of excellence in healthcare. Mon, 01 Jan 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/11808 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/11807 Title: Original Article Fall prevention among older adults in KSA: Role of physical therapy Authors: Algudairi, Ghadah M.; Alrashed, Abeer M. Abstract: Objectives: Falls and fall-related injuries among older adults are a growing public health concern. Although multiple factors and co-morbidities are associated with falls, balance and gait disorders are among the most common causes. Physical therapists have expertise in fallrisk assessment and management. The purpose of this study was to assess the fall prevention services provided by physical therapists to older adults. Methods: During November and December 2021, an online survey was shared with physical therapists working in various regions in KSA. The survey covered demographic and professional characteristics, knowledge of risk factors, fall prevention practices in older populations, physical therapy departmental preventive services, and barriers to fall prevention. Results: A total of 289 therapists were included in the analysis. The primary fall risk factors were balance/gait disorders, impaired cognition, sensory/perceptive deficits, and environmental hazards. The most frequent practices were asking about fall history, identifying fall risk factors, and educating patients on prevention strategies. The most frequent preventive services provided were gait training, strength and balance exercises, and fall prevention education. Greater knowledge among physical therapists was significantly associated with several practices and services, but not with demographic and professional characteristics, or service barriers. Conclusion: Our findings indicated favorable knowledge but suboptimal practices among physical therapists. The identified prevention barriers underscore an urgent need for restructuring services, particularly emphasizing staff and patient education. Mon, 01 Jan 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/11807 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/11806 Title: Sygyzium claviflorum fruit extract preadipocyte differentiation inhibition in 3T3-L1 cells Authors: Zohdi, Rozaini M.; Adli, Muhammad A.; Mukhtar, Shahida M.; Junaidi, Awang H. Awang; Bakar, Md Zuki A. Abstract: Objective: Concerns over the increasing number of obese individuals and the associated health risks have prompted therapeutic option explorations. Similarly, this study aimed to establish Sygyzium claviflorum fruit extract (SCFE) anti-adipogenic attributes in 3T3-L1 cells. Methods: The polyphenolic compounds in SCFE were identified with Reverse phase-high performance liquid chromatography (RP-HPLC). Meanwhile, murine 3T3- L1 preadipocytes, measuring leptin levels, reactive oxygen species (ROS), and lipid and triglyceride (TG) contents were utilized during anti-adipogenic activity assessments. Concurrently, the effects of SCFE on adipogenic transcription factors were established with quantitative real-time-polymerase chain reaction (qRTPCR). Results: The RP-HPLC results indicated three polyphenolic compounds in SCFE, including one flavonoid (naringin) and two phenolic acids (syringic and p-coumaric). Although SCFE treatments (250-1000 mg/mL) did not result in cell toxicity, they significantly reduced dosedependent lipid accumulation, ROS production, and TG and leptin levels relative to control-differentiated adipocytes. Moreover, SCFEsuppressedsterol regulatory element binding protein-1 (SREBP-1), peroxisome proliferatoractivated receptor-gamma (PPAR-g), and CCAAT/ enhancer-binding protein-alpha (C/EBP-a) gene expressions during preadipocyte differentiation into adipocytes. Conclusion: The findings revealed the anti-adipogenic properties of SCFE, indicating its potential as a natural obesity management remedy. Nevertheless, more studies are necessary to elucidate the reactions resulting in SCFE anti-adipogenic effects and the active constituents responsible for the property. Mon, 01 Jan 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/11806 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/11805 Title: Computational exploration of palmitoyl-protein thioesterase 1 inhibition by Juniperus phoenicea L. for anti-dementia treatment Authors: Irsal, Riyan A. Putera; Gholam, Gusnia Meilin; Dwicesaria, Maheswari Alfira; Mansyah, Tiyara F.; Chairunisa, Fernanda Abstract: Objectives: Dementia, a growing concern globally, affects more than 55 million people a number projected to rise to 152 million by 2050. Current medications target Alzheimer’s disease, the most prevalent form of dementia. This study investigated Juniperus phoenicea L., a plant used in traditional Chinese medicine, as a potential inhibitor of palmitoyl-protein thioesterase 1 (PPT1), an enzyme associated with dementia. Methods: J. phoenicea phytochemicals were subjected to in silico docking against PPT1 (PDB ID: 1EH5). Docking simulations were performed in YASARA Structure with VINA scoring. Top-ranked ligands were subjected to ADMET analysis (admetlab 2.0, Protox 3.0) and PASS bioactivity prediction. Stability and reactivity were analyzed with DFT calculations (Gaussian 09), and 500 ns MD simulations (YASARA Structure, AMBER 14 force field) to assess protein-ligand complex stability. MM-PBSA was used to calculate binding free energies. Results: The docking simulations identified amentoflavone ( 9.6 kcal/mol) as the top hit, followed by ferruginol and quercetin 3-O-pentoside. Amentoflavone formed the most interactions (19) with PPT1. In silico toxicity analysis predicted amentoflavone and quercetin 3-O-pentoside to be safe, whereas ferruginol violated the Pfizer rule. The PASS server indicated a higher probability of activity for quercetin 3-O-pentoside (0.423) than amentoflavone (0.287) for dementia treatment. DFT calculations revealed similar electronic properties for both ligands, although amentoflavone showed slightly more favorable values. MD simulations demonstrated that amentoflavone, compared with to galantamine, had superior binding stability in the PPT1 binding pocket. Conclusion: This in silico study was aimed at identifying potential inhibitors of PPT1 from J. phoenicea phytochemicals, given that PPT1 is a target for developing new dementia medications. Our findings identified amentoflavone as a promising candidate for further investigation. These findings warrant further research to validate this compound’s potential as a PPT1 inhibitor for dementia treatment. Mon, 01 Jan 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/11805 2024-01-01T00:00:00Z