DSpace Collection:

Effectiveness of the Telemedicine Approach on Maternal Health Practices among Pregnant Women in Rural Areas

Mon, 01 Jul 2024 00:00:00 GMT

Title: Effectiveness of the Telemedicine Approach on Maternal Health Practices among Pregnant Women in Rural Areas Authors: Bonifasius; Kayika, I Putu Gede; Madjid, Omo Abdul; Adjie, Josef Maria Seno; Rumopa, Harold Immanuel Marceliano Abstract: Objectives: To systematically evaluate the current evidence on the effectiveness of the telemedicine approach on maternal practices in rural communities. The author hopes that this study offers a breakthrough to draw a solid conclusion regarding the feasibility of implementing telemedicine to improve maternal health in rural areas of Indonesia. Methods: A systematic literature search was performed using international databases, such as Cochrane, PubMed, EBSCOhost, Science Direct, Scopus, and Google Scholar, published from 2012 to August 31, 2022. Risk of bias assessment was conducted using the Cochrane Risk of Bias tools 2.0 for randomized controlled trials and converted to the AHRQ standards. Results: This study included fi ve randomized controlled trials from different countries, namely India, Ethiopia, and Kenya. Telehealth interventions, delivered using mobile applications, phone calls, or short text messaging, improved the number of ANC visits, safe childbirth in hospitals or by skilled staff, exclusive breastfeeding, and immunization compliance, with a signifi cant difference compared to the control group that received no intervention (p<0.05). Nevertheless, considering the already widely used mobile phone technologies in rural settings, it is now clear that the telehealth approach should be scaled up and implemented in clinical settings. Conclusion: Telehealth-based intervention is a promising approach to promote better maternal health practices among pregnant mothers in rural and low-resources settings. This approach has been proved to successfully made a signifi cant difference in terms of antenatal care visits and safe childbirth practice.

Expression of Yap Signaling Hippo Pathway in Cervical Pre-cancerous Lesions and Cervical Cancer

Mon, 01 Jul 2024 00:00:00 GMT

Title: Expression of Yap Signaling Hippo Pathway in Cervical Pre-cancerous Lesions and Cervical Cancer Authors: Rizal, Muhammad Masrur; Mustika, Arifa; Saraswati, Wita Abstract: Objective: To determine the expression of YAP in cervical pre-cancerous and cervical cancer lesions. Methods: Researchers systematically searched five databases using the checklist for Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) guideline and Newcastle-Ottawa Scale (NOS).. Inclusion criteria were the original study of YAP expression in cervical pre-cancerous lesions and cervical cancer, observational and experimental study, and using immunohistochemical techniques. The study protocol was registered in the PROSPERO database of systematic review (IDCRD42023407469). Results: The data search in this study followed the PRISMA Guideline, which includes phases of identification, screening, and inclusion of studies. Initially, 245 articles were identified across five databases: Pubmed (105), ScienceDirect (8), Scopus (29), Web of Science (26), and ProQuest (77). After removing duplicates, 157 studies remained. During the initial screening, 142 studies were excluded, leaving 15 studies for further evaluation. These were assessed based on the use of immunohistochemistry staining for YAP expression and staining result. Subsequently, ten studies were excluded for either not using immunohistochsmistry or lacking staining result, resulting in five studdies selected for qualitative analysis. These five studies were evaluated using the New Ottawa Scale, as detailed in Table 1, and their YAP Expression characteristics are summarized in Table 2. Conclusion: This systematic review showed that YAP expression at all levels ranging from normal tissue, cervical intraepithelial neoplasia, squamous cell carcinoma, and adenocarcinoma had increased expression in the cytoplasm or cell nucleus following the development of cervical cancer and tumorigenesis influenced by intra-tumor heterogeneity for YAP expression. YAP is expressed in the cytoplasm and nucleus, with different functions. YAP expression in these two sites Excessive YAP expression will trigger epithelial changes into mesenchyme which also plays a role in cancer development. This YAP expression also correlates with HPV, in which YAP levels will be maintained and increased.

Pregnancy after Succesful Fallopian Tube Recanalization

Mon, 01 Jul 2024 00:00:00 GMT

Title: Pregnancy after Succesful Fallopian Tube Recanalization Authors: Gunardi, Eka Rusdianto; Rahmi, Trisha Alya; Fadila, Nur Fitri Abstract: Objective: To report a pregnancy that ensued following the successful recanalization of a previously sterilized fallopian tube. The novel aspect of this report is its demonstration of a successful intrauterine pregnancy post-recanalization, despite a prior ectopic pregnancy resulting from tubal sterilization. Methods: Case report Case: A 35-year-old woman successfully conceived after the recanalization of a previously sterilized fallopian tube. It is noteworthy that she had previously experienced an ectopic pregnancy due to the tubal sterilization procedure. Conclusion: This case study highlights the potential for successful pregnancy following fallopian tube recanalization, even after an ectopic pregnancy caused by a prior sterilization procedure. This report underscores the complexity of reproductive outcomes in these scenarios.

Hypertriglyceridemia - Induced Acute Pancreatitis in Pregnancy

Mon, 01 Jul 2024 00:00:00 GMT

Title: Hypertriglyceridemia - Induced Acute Pancreatitis in Pregnancy Authors: Pridianto, Faris Aziz; Sunarko, Agung Abstract: Objective: To describe the prompt and successful treatment of an hypertriglyceridemia-induced acute prancreatitis in pregnancy complicated by severe preeclampsia case in a tertiary-level hospital in Indonesia. Methods: A Case report. A 33-year-old woman, G3P2A0 at 32/33 weeks of gestation, presented with shortness of breath following severe heartburn, nausea, and fever. She had been experiencing constant thirst and frequent urination. Her level of consciousness was decreased (GCS E2V3M4), and she exhibited high blood pressure and tachycardia. There was no history of high blood pressure during her routine antenatal care. Laboratory tests revealed a leukocyte count of 22,670/μL, a random blood sugar level of 713 mg/dL, severe metabolic acidosis on blood gas analysis, an amylase level of 1,004.8 U/L, a lipase level of 899.4 U/L, and triglycerides at 789 mg/dL. An abdominal CT scan with contrast confi rmed acute pancreatitis. Given her poor general condition, she was sedated and intubated. The termination of her pregnancy was postponed to focus on stabilizing her condition in intensive care. Discussion: In pregnant patients presenting with severe heartburn and no prior history of hypertension, acute pancreatitis should be considered as a potential diagnosis. In the absence of alcohol abuse risk factors, hypertriglyceridemia should be investigated as a probable cause. Conclusion: Pregnant patients presenting with symptoms of shortness of breath, severe heartburn, along with hypertriglyceridemia should be considered for acute pancreatitis as a differential diagnosis.