http://localhost:8080/xmlui/handle/123456789/10322 Wed, 08 Apr 2026 21:45:45 GMT 2026-04-08T21:45:45Z http://localhost:8080/xmlui/handle/123456789/10400 Title: Management of Vulvovaginal Candidiasis in Pregnancy Authors: Levina, Jessica; Ocviyanti, Dwiana; Adawiyah, Robiatul Abstract: Objective: This study aimed at describing VVC therapy that has been proven to be safe in pregnancy. Background: Pregnancy is a risk factor for vulvovaginal candidiasis (VVC). The most common cause of VVC in pregnancy is Candida albicans. When symptoms and signs of vulvar pruritus, pain, swelling, redness, burning sensation, dyspareunia, dysuria, vulvar edema, fi ssures, excoriation and vaginal discharge are found which suggest VVC, it is necessary to perform microscopic examination and/or fungal culture to establish the diagnosis of VVC. In pregnancy, VVC must be treated as soon as possible because it can cause adverse perinatal outcomes such as premature labor, premature rupture of membranes, low birth weight babies and fetal brain problems. Unfortunately, prescription oral antifungal therapy in pregnancy is still found. Treatment with oral antifungal is not recommended because of the risk of causing congenital abnormalities in the fetus. Methods: Literatures in English and Indonesian were searched with topic restrictions on the type of publication for the last thirty years. Summary: Topical intravaginal antifungal therapy such as clotrimazole and nystatin, are the recommended treatment for VVC in pregnancy that has been shown its safety. In addition, giving prophylaxis in the last trimester of pregnancy in asymptomatic VVC cases provides good pregnancy and neonatal outcomes but is still debated. In severe, prolonged or recurrent cases of VVC, other co-infections may be sought which may also need to be managed. Administration of probiotics for VVC therapy still requires further research. Mon, 01 Apr 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/10400 2024-04-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/10399 Title: Successful Management of an Unruptured Extrauterine Pregnancy in a Woman with a History of Prior Miscarriage at Tertiary Hospital in Indonesia Authors: Mukti, Achmad Fahrur Rozi; Tunjungseto, Arif Abstract: Objective: To describe the prompt and successful treatment of an extrauterine pregnancy case in a tertiary-level hospital in Indonesia. Methods: We report a case of prompt and successful management of unruptured tubal pregnancy in the dr. Soetomo General Hospital Surabaya. Results: A 32-years-old woman presented with lower abdominal pain and vaginal bleeding one days before admission. She was sexually active, used no contraceptives, and had a history of one miscarriage. On examination, she was hemodynamically stable. A bimanual exam revealed cervical motion tenderness and pain. A high human chorionic gonadotropin (hCG) level (1,725 IU/L) and a left-sided mass, highly suspected as an extrauterine gestational sac confi rming a 6 week, 1 days age of pregnancy without sign of free fl uid in the abdomen nor fetal heart rate on ultrasound, prompted diagnostic laparoscopy. We found a tubal pregnancy located on the ampullae of the left fallopian tube with minimal hemoperitoneum (50 ml). A chromopertubation test was done to ensure a patent right fallopian tube, so we did a salpingectomy. The patient recovered well and was discharged home on day 2 post-procedure. Conclusion: Early diagnosis is vital and feasible to prevent morbidity and mortality in women with ectopic pregnancy. All sexually active women complaining painful abdomen or vaginal bleeding must be examined for an ectopic pregnancy to enable early diagnosis and prompt treatment. A laparoscopic surgery done by a trained individual provided a safe and minimally invasive intervention to this case. Mon, 01 Apr 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/10399 2024-04-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/10398 Title: Concordance and Acceptability of HPV DNA Genotyping Test by Patient’s Self-Sampling Against Clinician Sampling Authors: Indarti, Junita; Syaharutsa, Danny Maesadatu; Surya, Ilham Utama; Alda, Kristian Abstract: Objectives: To determine the effectiveness of self-sampling method, especially during the COVID-19 pandemic and considering Indonesia’s cultural context. Methods: This study utilized a cross-sectional design, and involved patients at the Gynecology and Colposcopy Clinic of Dr. Cipto Mangunkusumo General Hospital. The estimated sample size was 48, determined using a diagnostic test formula. The sample population consisted of female patients with positive VIA or abnormal Pap smear results. Each patient underwent HPV DNA self-sampling and clinician sampling tests using the GenoFlow HPV Array technique and continued with colposcopy. All patients were also administered a questionnaire consisting of eight questions about their perspective on the self-sampling HPV DNA test. The data analysis employed a 2 × 2 table using SPSS version 20, and Cohen’s kappa coeffi cient was calculated to measure the agreement between the sampling results of patients’ and clinicians’. Results: Among the examinations conducted by clinicians, there were 33 patients with positive HPV results, whereas through self-sampling, there were 28 patients with positive HPV (p=0.00). High risk HPV was the most commonly observed, with HPV type 16 appearing the most (15%). Based on these data, the self-sampling sensitivity, specifi city, positive predictive value, and negative predictive value were 85%, 100%, 100%, and 75%, respectively, with a concordance rate of 89.6%. The Cohen’s Kappa coeffi cient between samples taken by the clinician and self-sampling resulted in K=0.778, which is considered a good agreement (K=0.61-0.80). All patients concluded that the procedure was easy (100%), and the majority (60.5%) expressed a preference for the self-sampling method. Conclusion: There is a good agreement between the results of self-sampling and clinician sampling for detecting HPV DNA, with patients positively accepting the self-sampling method, indicating its potential as an effective cervical cancer screening method. Mon, 01 Apr 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/10398 2024-04-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/10397 Title: CA-125 Examination as a Predictor the Resectability of Advanced Stage of Ovarian Cancer Authors: Muhammad, Syamel; Setiawan, Muhammad Rudy Abstract: Objective: To determine serum CA-125 examination as predictor in predicting the resectability of advanced ovarian cancer at dr. M. Djamil Padang Methods: The research sample was obtained using a consecutive sampling technique, wherein samples were collected one by one within the specifi ed timeframe until the required sample size was achieved. Results: The mean CA-125 level among respondents was 589.66 U/mL with a standard deviation of 841.55 U/mL. The study also revealed that a CA-125 cutoff value of 337.5 U/mL demonstrated high sensitivity (92.31%) and specifi city (90.90%) in predicting the resectability of ovarian cancer. Conclusion: Serum CA-125 examination shows a promising result in predicting the resectability of advanced ovarian cancer at dr. M. Djamil Padang Mon, 01 Apr 2024 00:00:00 GMT http://localhost:8080/xmlui/handle/123456789/10397 2024-04-01T00:00:00Z