http://localhost:8080/xmlui/handle/123456789/97 2026-04-11T21:43:04Z http://localhost:8080/xmlui/handle/123456789/12094 Title: Discover How Ashwagandha May Impact Health: A Comprehensive Review Authors: Alzrigat, Omar Naseem; Qusous, Yazeed Nabeel Al; Masadeh, Dema Maher; Qusous, Madleen Nabeel Al Abstract: Withania somnifera (Ashwagandha) is a medicinal herb that has been commonly utilized in traditional medicine for millennia, particularly in Ayurvedic practices. The root of the plant is pharmacologically active and has been used for its aphrodisiac, diuretic, anti-helminthic, narcotic, tonic, and stimulant properties. Additionally, other parts of ashwagandha, including the leaves, shoots, seeds, and berries, contribute to its health-promoting effects and the potential for improving longevity. This plant is composed of many bioactive compounds which exhibit a myriad of health-enhancing properties. Contemporary research has focused on the multifaceted bioactivities of ashwagandha, revealing promising impacts such as anticancer, antioxidant, and anti-inflammatory activities, among other therapeutic applications. This review was planned to find the most recent findings, providing an examination of the active constituents of ashwagandha, their biological activities, and a critical assessment of any associated safety concerns and potential toxicity. 2025-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/12089 Title: A Review: Medicinal Uses, Phytochemistry and Pharmacological Properties of Plants from the Hermannia Genus Authors: Nhlapo, Mfundisi; Ngobeni, Brian; Manduna, Idah Abstract: Introduction: Medicinal plants play a pivotal role in treating illnesses and modern medicines are still being derived from plants. Hermannia genus is a significant traditional herbal medicine. This review evaluates the medicinal uses, phytochemistry and pharmacological properties of plants from the genus Hermannia genus based on available research. Methods: Studies accessed from online research databases were systematically selected and analysed to construct a comprehensive review of the medicinal uses, phytochemistry and pharmacological properties of plants from the genus. Results: Hermannia species are used in traditional medicine to treat or manage; respiratory conditions, gastrointestinal issues, skin conditions, sexually transmitted infections, and diabetes. Scientific findings also discovered promising pharmacological activities within members of the genus such as antimicrobial, anti-inflammatory, antioxidant, antidiabetic and anticancer activities. To date, over 30 types of secondary metabolites have been identified from the genus, including the 2 pure compounds that were isolated and tested for pharmacological activities. Further research must prioritize other unexplored species of the genus and efficacy and mechanism of action studies on isolated compounds. Conclusion: The genus Hermannia is important in the treatment of diseases of high public health concern. The pharmacological studies and presence of secondary metabolites and bioactive compounds further validates the traditional uses of the genus. Therefore, the findings suggest that the genus has species that may serve as candidates for novel drug discovery for the treatment of various illnesses. Efficacy and mechanism of action studies still need to be conducted on isolated compounds and other unexplored species of the genus. 2025-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/12084 Title: In-silico Analysis of Molecular Interaction Between Silk Proteins with BMP-2 Type IA and Type II Receptors Authors: Thiagaraj, Nandhinee; Ashokkumar, Lekha; Sabarish, Ram; SK, Balaji Abstract: Background: Alveolar ridge defects are commonly associated with delayed tooth replacement. Natural biomaterial with enhanced regenerative potential is always sought after as a primary choice for ridge reconstruction. Silk, a biopolymer with its constituent proteins (fibroin and sericin) has recently demonstrated promising outcomes in vitro. However, the molecular mechanism by which this occurs remains to be elucidated. Objective: We assessed the molecular interactions between silk proteins bone morphogenetic protein (BMP)-2 type IA and type II receptors using molecular docking. Methodology: The N-terminal domain of silk proteins and structural complex of BMP-2 type IA and type II receptors were considered for protein–protein docking using the high ambiguity-driven protein–protein docking (HADDOCK) server. HADDOCK scores are a measure of the predicted stability of the protein–protein complex, and a lower score indicates a more stable complex and a higher affinity for binding. Results: The HADDOCK scores and root mean square deviation value for interaction between silk proteins with BMP-2 type IA and type II receptors were (−114.2 ± 25.0 and −143.1 ± 11.3) and (2.9 ± 0.4 and 1.9 ± 0.5), respectively, for fibroin and (−1.8 ± 15.6 and −9.7 ± 25.2) and (3.5 ±0.3 and 0.9 ± 0.6), respectively, for sericin. Conclusion: The interaction between fibroin and BMP-2 receptors was more stable with higher affinity. 2025-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/12080 Title: Formulation Strategy and Excipient Selection for Tribulus terrestris L. Tablets: A Quality-Based Approach Authors: Dovchinsuren, Baigalmaa; Hu, Wang Qin; Dambiinyam, Jambaninj; dkk. Abstract: Background: To develop and evaluate a tablet formulation containing standardized dry extract of Tribulus terrestris L.—a plant traditionally used in Mongolian medicine—by focusing on excipient optimization and pharmaceutical quality assessment. Methods: Tablets were manufactured using the wet granulation method, incorporating an extract standardized to 54.45% dioscin. Various excipient ratios were investigated to determine the optimal formulation. Dioscin content was quantified using UV-visible spectrophotometry. Results: The optimized formulation comprised 25% dry extract, 34% lactose, 34% microcrystalline cellulose, 6% PVPP, 0.5% magnesium stearate, 0.5% talc, and 4.5% HPMC. The tablets demonstrated acceptable pharmaceutical characteristics, including an average weight of 0.113 ± 0.001 g, hardness of 0.83 ± 0.23 MPa, friability of 98.17 ± 0.65%, and disintegration time of 7.30 minutes. The dioscin content was 13.50 ± 0.50 mg/g, with an assay recovery of 95.51%. Dissolution exceeded 83% in both media within 45 minutes. The similarity factor (f₂) confirmed equivalent dissolution profiles. Conclusion: The developed T. terrestris tablet formulation met pharmacopoeial standards and exhibited consistent physical, chemical, and biopharmaceutical performance, supporting its potential as a standardized herbal medicinal product for clinical and commercial application. 2025-01-01T00:00:00Z