http://localhost:8080/xmlui/handle/123456789/7774 1 - 219 2026-04-08T22:54:04Z http://localhost:8080/xmlui/handle/123456789/7823 Title: Effectiveness of stingless bee (Kelulut) honey versus conventional gel dressing in diabetic wound bed preparation: A randomized controlled trial Authors: Rosli, Mohamad A.; Nasir, Nur A. Mohd; Mustafa, Mohd Z.; dkk. Abstract: Purpose: Kelulut honey contains trehalulose and has high antioxidant content, such as phenolic and flavonoid substances, which can promote wound healing. This study evaluated the effectiveness of Kelulut honey in diabetic wound healing compared to a commercially available conventional gel dressing (Intrasite gel). Methods: A prospective, randomized, single-blinded control trial was performed on eligible diabetic patients with full-thickness cavity wounds. Patients’ demographics, size and site of wounds, and baseline routine blood investigations were recorded. The wounds were dressed every other day with Kelulut honey for the intervention group or gel for the control group. The wound size reduction and granulation tissue formation percentage were calculated every 6 days for 1 month. Results: Seventy-one patients were randomized. After 30 days of follow-up, 62 participants were available for analysis: 30 from the control group and 32 from the treatment group. The control group had increased granulation tissue at baseline and more wounds on the lower limb and posterior trunk. Both groups showed an increasing mean and median percentage of wound epithelialization and granulation tissue over time, with significantly higher values at every timepoint in the honey group (p < 0.05). However, repeated measures analysis of variance and analysis of covariance revealed no significant interaction effect between the different treatments and time, with F (2.02, 121.28) ¼ 0.88, p ¼ 0.417 and F (1.60, 93.95) ¼ 0.79, p ¼ 0.431, respectively. Conclusion: This study revealed that Kelulut honey was comparable to and as effective as the conventional gel in treating diabetic wounds in terms of promoting epithelialization and granulation tissue formation. 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7822 Title: Speckle tracking echocardiography for diagnosis of right ventricular failure in children with totally corrected tetralogy of Fallot in Sulaimani, Iraq Authors: Kamal, Niaz M.; Salih, Aso F.; Ali, Bushra M. Abstract: Objectives: The study was aimed at using speckle tracking echocardiography as a novel technique to diagnose right ventricular failure (RVF) in children with total correction of tetralogy of Fallot (TOF) through surgery. Methods: A quasi-experimental study was performed at the Children’s Heart Hospital of Sulaimani for 9 months. A total of 150 children with completely repaired TOF were enrolled to investigate RVF. Conventional echocardiographic data were recorded, including right ventricular (RV) ejection fraction (EF), tricuspid annular plane systolic excursion (TAPSE), myocardial performance index (MPI), and RV end-systolic and diastolic volume (RVESV and RVEDV). Additionally, speckle tracking was performed for the regional and longitudinal strain and strain rate in four-chamber apical view. RVF diagnosis was determined on the basis of electrocardiography measurement of P-wave dispersion, T-wave dispersion, and QRS duration. Results: Children with repaired TOF who were diagnosed with RVF through conventional echocardiography exhibited abnormalities with respect to children with normal RV function, including a TAPSE of 1.3 0.11 cm, RVEF of 35.5 6.72, RVESV of 69.8 15.13 ml, RVEDV of 110.1 14.13 ml, MPI of 0.60 0.12, and Pmax of 52.4 14.08. The use of speckle tracking in RVF diagnosis revealed a relatively lower longitudinal strain and strain rate ( 12.1 2.3 and 0.9 0.3, respectively) in the children with RVF. Moreover, longitudinal right ventricular strain was positively correlated with TAPSE (r ¼ 0.656) and EF (r¼ 0.675), and negatively correlated withRVEDV (r¼ 0.684), RVESV (r¼ 0.718),MPI (r¼ 0.735), and Pmax (r¼ 0.767). Conclusions: The application of speckle tracking with the longitudinal RV strain and strain rate to estimate RV function in children with repaired TOF is a new advanced method that, compared with conventional echo, significantly improves the diagnosis of regional myocardial deformations and cardiac muscle motion velocity. 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7820 Title: Polymethylmethacrylate-hydroxyapatite antibacterial and antifungal activity against oral bacteria: An in vitro study Authors: Saskianti, Tania; Wardhani, Karina K.; Fadhila, Naura; Wahluyo, Soegeng; Dewi, Ardianti M.; Nugraha, Alexander P.; Ernawati, Diah S.; Kanawa, Masami Abstract: Objective: Reconstruction of alveolar bone defects resulting from aging, trauma, ablative surgery or pathology, remains a significant clinical challenge. The objective of this study was to investigate the antibacterial and antifungal activities of mixed polymethylmethacrylate-hydroxyapatite (PMMA-HA) against oral microorganisms. Our findings could provide valuable insights into the prospective application of PMMA-HA as a synthetic bone graft material to manage alveolar bone defects via tissue engineering. Methods: HA powder was obtained from the Center for Ceramics in Indonesia andPMMAgranules were obtained from HiMedia Laboratories; these were prepared in 20:80, 30:70, and 40:60 ratios. The antibacterial diffusion method was then performed against Staphylococcus aureus, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Fusobacterium nucleatum, while the antifungal diffusion method was used to test against Candida albicans. Standardized protocols were used for microbial culturing and inhibition zones were measured with digital calipers. Statistical analyses included one-way ANOVA and KruskaleWallis tests, supplemented by post-hoc Tukey HSD tests. Results: A PMMA-HA scaffold with a 20:80 ratio demonstrated the highest antibacterial activity against S. aureus, A. actinomycetemcomitans, P. gingivalis, and F. nucleatum. This was followed by the 30:70 and 40:60 ratios in terms of antibacterial activity. Statistical significance was achieved with p < 0.05 in comparison to controls. However, none of the PMMA-HA ratios showed antifungal activity against C. albicans. Conclusion: PMMA-HA scaffolds have significant activity against bacteria, but not against fungi. 2024-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7819 Title: Vitamin D receptor expression in hydatidiform mole and gestational trophoblastic neoplasia: A cross-sectional study Authors: Sasotya, RM Sonny; Kustiandi, Arieff; Hidayat, Yudi Mulyana; Effendi, Jusuf Sulaeman; Permadi, Wiryawan; Harsono, Ali Budi; Mulyantari, Ayu Insafi; Hernowo, Bethy S. Abstract: Objective: Vitamin D receptor (VDR) exerts anti-cancer properties in a variety of cancers. The purpose of this study was to investigate the expression of VDR in patients with hydatidiform mole (HM) and gestational trophoblastic neoplasia (GTN). Methods: This is a cross-sectional study involved 61 specimens of HM (n ¼ 37, 60.7%) and GTN (n ¼ 24, 39.3%) was collected from the biopsy. An immunohistochemistry was used to asses the VDR expression. Student’s t-test and ManneWhitney test were used to compare the expression of VDR, including VDR staining intensity, VDR distribution, and histoscore, between HM and GTN tissue specimens. Results: No significant differences in age and parity were noted between patients with HM or GTN (p > 0.05). The VDR staining intensity of GTN tissue specimens was significantly lower than that of HM tissue specimens (2.3 0.8 vs. 2.8 0.5, p ¼ 0.008). In addition, the histoscore for GTN tissues was significantly lower than that for HM tissues (7.3 3.2 vs. 9.4 28, p ¼ 0.016). However, no significant differences in VDR distribution between GTN and HM tissues were observed (3.3 0.8 vs. 3.3 1.0, p ¼ 0.525). Conclusion: Low VDR expression is associated with GTN, whereas high VDR expression is associated with HM, suggesting that the expression of VDR may regulate the severity of gestational trophoblastic disease. 2024-01-01T00:00:00Z