http://localhost:8080/xmlui/handle/123456789/7251 2026-04-09T06:32:43Z http://localhost:8080/xmlui/handle/123456789/8791 Title: Role of Spices in Offering Natural Immunity to Fight Various Diseases Authors: Johnson, T. Sudhakar; Narayana, D. B. Anantha Abstract: Adequate nutrition intake is one of main factors to strengthen immunity. Traditional and cultural practices of food consumption involve use of several spices in limited quantities as part of food. Spices have offered versatile biological effects due to presence of valuable biochemicals. The aim of the present paper is to review published scientific evidence on potential role of spices in offering innate and adaptive immunity to human body. It has been demonstrated that, turmeric, one of the widely used spices, acts as an anti-viral agent through inhibition of viral entry into cells, suppression of viral replication and modulation of cytokines. A field study revealed that nations with higher consumption of spices have shown lesser COVID-19 cases and higher recovery rates. Further, spices also have shown to possess antioxidant activity superior or equivalent to ascorbic acid and are known to regulate inflammation processes. Evidence generated from the published literature is compelling to arrive at a conclusion that consumption of spices might improve immunity there by offering protection against various diseases including COVID-19. It is also noted that there are lesser number of human clinical trials in this area which warrants immediate attention to provide scientific evidence to immunity offered by spices. Key words: COVID-19, Spices, Immunity, Diet, Nutrition. 2021-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/8790 Title: Evaluation of Antioxidant Activity of Some Medicinal plants and their Combination Authors: Joshi, Tanuj; Juyal, Vijay Abstract: Introduction: Oxidative Stress leads to several complications within the human body. It is the reason behind the generation of several diseases. Free radicals if generated in excess amount can damage the body to a great extent. Finding newer and potent medicinal plants that can fight oxidative stress can be useful in combating the harmful effects of free radicals. Methods: In the current study ethanolic extract of Ocimum kilimandscharicum, Thymus serpyllum, Spilanthes acmella and their combination in equal ratio were used for their ability to counter oxidative stress. The plants were collected from the district of Pithoragarh, Uttarakhand and extracted by soxhlet’s apparataus using absolute ethanol (99.9%). The extracts were then dried and used for the study. Result: It was seen that highest absorbance was shown by ascorbic acid at the lowest as well as the highest concentration in the reducing power assay. Also, the combination of the extracts showed the highest absorbance among all the extracts at both the lowest and highest concentration. Conclusion: A higher absorbance indicates a better antioxidant potential. The best effect was shown by the combined extract among all the extracts. Key words: Oxidative stress, Reducing power, Flavonoids, Phenols 2021-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/8789 Title: Cardioprotective Role of Partharishtam on Isopreterenol Induced Myocardial Infarction in Animal Model Authors: G. Narayanan, G. Narayanan; K Prabhu, K Prabhu; Bandhu Chaudhury, Anath Abstract: Myocardial infarction (MI) is one of the key causes of high death rate globally. We report the cardio protective effect of an Ayurvedic polyherbal formulation Partharishtam on isoproterenol induced myocardial infarction on albino rats. Administration of Isoproterenol to normal albino rat triggers MI evident from the significant changes in key biomolecules tested in blood serum and cardiac tissues. The cardio protective role of Partharishtam was compared with a standard medicine, Propranolol on some of the known identifying markers of MI such as, Troponin I and T, creatine phosphokinase serum (CPK-S), creatine phosphokinase myoglobulin isozyme fraction (CPK-MB) and oxidative enzymes like super oxide dismutase (SOD), reduced glutathione (GSH) and catalase. There was an appreciable decrease in the levels of Troponin 1 and T, CPK-S and CPK-MB after the treatment of Partharishtam on Isoproterenol induced MI rats. In vivo anti-oxidative enzyme studies also revealed the increase in the levels of SOD, GSH and catalase to near normalcy after the treatment of Partharishtam in MI rats, which is very much comparable to the commonly used drug Propranolol to treat MI patients. Histopathological analysis confirmed the cardio protective properties of Partharistham in rat model. We did not find any side effects or toxicity of Partharishtam when tested on the normal rats. Thus, polyherbal formulation Partharishtam could be considered as safe medicine for MI. Key words: Myocardial Infarction, Partharishtam, Polyherbal, Isoproterenol, Propranolol, Troponin I, Troponin T, Creatine phosphokinase, SOD, GSH, Catalase 2021-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/8788 Title: The Anti-Malarial Effect of Thespesia populnea (L.) Soland ex Correa Extract Using Malaria Mice Model Infected with P. berghei Authors: Diah Utami, Prawesty; Setianingsih, Herin; Pratama Wiyono, Rico; Firdha Syafitri, Indira Abstract: Introduction: Malaria is a re-emerging disease that still causes high morbidity and mortality rates. Reports of malaria therapy, encouraging studies to find new therapies based on plants and adjuvant in malaria infection. Thespesia populnea or portia tree leaf extract is a plant that has been shown to have anti-inflammatory, antibacterial and antifungal effects. The aim of this study was to analyze the effect of Thespesia populnea leaf extract as antimalarial levels, and and its effect on hemoglobin levels in BALB/C mice infected with Plasmodium berghei ANKA (PbA). Methods: The study was true experimental laboratories using post-test only group design. Using 27 mice were randomly divided into 3 groups: Group with aquades (G1), Group received Chloroquine (G2), and Group with 200 mg/kg bw of Thespesia populnea (L.) Soland ex Correa extract and Chloroquine (G3). The degree of parasitemia was observed serially from the first day to the fourth day. Observation of the number of leukocytes and hemoglobin on the fourth day after the mice were terminated. Results: The results of statistical analysis showed that the administration of Thespesia populnea leef extract 200 mg/kg bw with chloroquine had the effect of decreasing the degree of parasitemia and increasing hemoglobin significantly than G1 group, but there was no significant difference with G2 group, although descriptively there were differences. Conclusion: Based on the results of this study, it can be concluded that Thespesia populnea or portia tree leaf extract has an anti-malarial effect and can also significantly prevent anemia. Key words: BALB/C, Hemoglobin, Malaria, Parasitemia, Thespesia populnea extract. 2021-01-01T00:00:00Z