http://localhost:8080/xmlui/handle/123456789/7001 2026-04-11T13:18:37Z http://localhost:8080/xmlui/handle/123456789/7031 Title: Efektivitas Ekstrak Etanol Polong Petai [Parkia speciosa Hassk.] sebagai Anti Ulcer Pada Tikus Wistar yang Diinduksi Etanol Absolut Authors: Fitrya; Amriani, Annisa; Novita, Rennie Puspa; Ahmadi, Adik; Nabilah, Rizka Abstract: Petai (Parkia speciosa Hassk.) is a species that has long been cultivated in Indonesia. Petai seeds are used by the community for consumption as fresh vegetables, while petai fruits are considered waste. P. speciosa pods contain phenolic compounds with various pharmacological activities, including antioxidant and anti-inflammatory. This study aimed to evaluate the effectiveness of P. speciosa pod ethanol extract as an antiulcer agent in animals induced by acute peptic ulcer with absolute ethanol. The antiulcer effect of the extract [doses of 100, 200 and 400 mg/kgBW] was evaluated through ulcer index, physicochemical properties of gastric juice and histopathological analysis. The results showed that P. speciosa pod extract was able to reduce ulcer index, gastric fluid volume, total acidity and increase pH which was not significantly different from omeprazole (p>0.05). Photomicrograph analysis showed improvement in the structure of the mucous membranes in the extract-treated animals. Based on these findings, it can be concluded that P. speciosa extract has potential as an antiulcer agent. 2022-04-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7025 Title: Identifikasi Determinan Molekul Interaksi STK630921 pada Interleukin-17A Authors: Riandono, Fransiscus Deddy; Istyastono, Enade Perdana Abstract: Interleukin-17A (IL-17A) is a pro-inflammatory cytokine that is involved in the pathogenesis of several diseases, including psoriasis, rheumatoid arthritis, cancer, diabetes, and end-stage kidney disease. Increased serum levels of IL-17A provide a clue of the association between IL-17A in the incidence of diabetic nephropathy. This association was also clarified by the finding that inhibition of IL-17A activity can reduce albuminuria, kidney injury and can delay the progression of diabetic nephropathy. This role of IL-17A makes it a potential target of choice for the treatment of diabetic nephropathy, which so far relies on optimal control of the renin-angiotensin system. This study aims to identify the molecular determinants of the STK630921 interaction to IL17A. The experiment was conducted by docking the STK630921 molecule to the protein IL-17A, followed by molecular dynamics simulation for 15 ns. Identification of molecular determinants was carried out using the PyPLIF-HIPPOS software on the molecular dynamics simulation results. This study succeeded in identifying amino acids that play an important role, namely His29, Trp67, Asn27, Lys114 and Glu95 with aromatic interactions and hydrogen interactions as the types of interactions that play an important role in the activity of STK630921 in the protein structure of 4HR9. 2022-04-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7024 Title: Kajian Pengelolaan dan Regulasi Obat Tidak Terpakai dan Obat Kedaluwarsa di Rumah Tangga di Kabupaten Padang Pariama Authors: Augia, Trisfa; Ramadani, Mery; Markolinda, Yessy Abstract: Advances in pharmaceutical industries have an impact on increasing the type and number of pharmaceutical products circulating in the community. However, not all pharmaceutical products are used rationally, causing the remaining drugs to become expired. Drug waste can pollute the environment if not managed properly. The purpose of this study is to review the management and regulation of waste drugs and expired drugs in households. This research was conducted in Padang Pariaman district using a mixed methods approach to 148 respondents and 6 informants. Based on the results of the study, more than half of respondents had leftover drugs at home (63.5%) with the main reason due to health conditions improved (61.7%). Many residual drug sources come from prescriptions and the most common types of drugs are non-steroidal anti-inflammatory drugs. Nearly half of respondents dumped the leftover medicine in a household garbage (41.5%). Information about the proper drug disposal practices had not been obtained by most respondents (70.3%). About 68.2% of respondents unaware that improperly disposing of drugs can cause environmental damage and harm public health. Therefore, local government should be encouraged to promote the proper drug disposal and enact regulations on the management of waste drugs at home. 2022-04-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7022 Title: Uji Aktivitas Antibakteri Ekstrak Bakteri Endofit dan Identifikasi Bakteri yang Diisolasi dari Kulit Jeruk Nipis (Citrus aurantifolia Swingle) Authors: Rustini; Ismed, Friardi; Nabila, Gina Sasha Abstract: Lime peel (Citrus aurantifolia Swingle) is a plant part widely used for treatment with various pharmacological activities. However, little is known about the study of endophytic bacteria associated with the peel of this plant. This study aimed to isolate endophytic bacteria from lime peel and evaluation its activity in inhibiting the growth of Staphylococcus aureus, Escherichia coli, and Methicilin-Resistant Staphylococcus aureus (MRSA) bacteria. Six bacterial isolates were isolated and fermented in Nutrient Broth (NB) media. The results of the fermentation were extracted using ethyl acetate as a solvent. The crude extract of each isolate was evaluated for its antibacterial activity using the Kirby-Bauer diffusion method. According to the inhibition zone measurements, it was shown that the extracts from isolate 3 and isolate 5 had a strong inhibitory diameter of >10 mm. Qualitative identification showed that the extract from isolate 3 showed positive results for alkaloids and flavonoids, while isolate 5 was positive for alkaloids, flavonoids, and polyphenols. These isolates were then identified, and it was reported that isolate 3 was Bacillus velezensis JS25R, and isolate 5 was Staphylococcus sp. This extract has been proven to have the potential as antibacterial and to be further isolated and developed by its activit 2022-04-01T00:00:00Z