http://localhost:8080/xmlui/handle/123456789/6998 2026-04-09T05:13:17Z http://localhost:8080/xmlui/handle/123456789/7336 Title: Linguistic Validation of Indonesian Version of the Audit of Diabetes-Dependent Quality of Life Questionnaire Authors: Amelia Rooswita, Putri; Nita, Yunita; Zairina, Elida; Nugraheni, Gesnita; Libriansyah, Libriansyah Abstract: Abstract Background: One of the impacts experienced by diabetes mellitus patients is a decrease in their quality of life. The Audit of Diabetes-Dependent Quality of Life (ADDQoL) is a widely used individualized diabetes-specific quality of life measure. However, there was no version available in the Indonesian language. Objective: This study is aimed to undertake linguistic validation, including a cultural adaptation of the ADDQoL questionnaire into the Indonesian language. Method: The original developer granted permission to use and modify the questionnaire. The international linguistic validation procedure developed by the Mapi Research Institute was used. There were six steps involved: forward translation, reconciliation, back translation, expert panel review by a psychologist and clinician, cognitive debriefing with diabetes patients, and proofreading. Result: Problems that arose during the linguistic validation process were resolved by finding conceptually equivalent alternatives and changing sentence structures to achieve equivalence in language, concept, and culture with the original version of the ADDQoL. The developer's team reviewed and discussed all actions taken. Cognitive debriefing interviews with five respondents showed that the ADDQoL questionnaire was simple to understand. Conclusion: The Indonesian version of the ADDQoL is linguistically and culturally validated. Further studies are needed to confirm the structure and reliability of the Indonesian ADDQoL. Keywords: ADDQoL, diabetes mellitus, cultural adaptation, quality of life, linguistic validation 2021-11-30T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7335 Title: Comparative Analysis of Actual Cost and INA CBG Rate in Diabetic Gangrene Inpatients Authors: Putri Kinanti, Diajeng; Athiyah, Umi; Nita, Yunita; Noor Diansyah, Muhammad Abstract: Abstract Background: Diabetic gangrene is a complication of diabetes mellitus that imposes a substantial financial burden on patients and their families as well as the health care system. Objective: To determine the total cost of disease, and the difference between real cost and INA CBG rate for diabetic gangrene inpatients from January - December 2017 at Universitas Airlangga Hospital, Surabaya Methods: The study was conducted retrospectively by using a total sampling method. The perspective used was the hospital perspective. This study's direct medical costs were laboratory, drug and consumable medical device costs, medical equipment rental, radiology examination, red cross, oxygen, service, and room costs. Data analysis was performed using an independent samples t-test. Results: The results showed that 148 patients met the inclusion criteria. The total real cost of diabetic gangrene inpatients at Universitas Airlangga Hospital in 2017 was IDR 1,339,949,381, and the total INA CBG rate for inpatients with diabetic gangrene was IDR 1,365,047,500. The difference was (p = 0.000) between real cost and INA CBG rate. Conclusion: There is a difference between the actual cost and the INA CBG rate for diabetic gangrene inpatients. Keywords: national health insurance, cost analysis, direct cost, diabetic gangrene, diabetes mellitus 2021-11-30T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7333 Title: Perbandingan Metode Sintesis Senyawa 1-benzil-3-(4-etil-benzoil)urea dan 1-benzil-3-(4-klorometil-benzoil)urea sebagai Calon Obat Antikanker Authors: Suhud, Farida; Hadi Tjahjono, Daryono; Achsendo Yuniarta, Tegar; Satrio Putra, Galih; Ika Sulistyowaty, Melanny Abstract: Abstract Background: The research of anticancer drugs is still being developed, especially on the hydroxyurea group. Objective: This study aimed to compare the synthesis methods of 1-benzyl-3-benzoylurea derivatives, namely 1- benzyl-3-(4-ethyl-benzoyl)urea and 1-benzyl-3-(4-chloromethyl-benzoyl)urea. Methods: Optimization of the synthesis method was carried out by comparing the synthesized products with and without reflux heating. The products obtained were subjected to structure elucidation analysis by using FTIR, 1H-NMR, and 13C-NMR. Results: The reflux synthesis method produced by-product compounds, which needed to be separated by column chromatography. The method without heating is preferred because it did not produce by-product compounds. Conclusion: The method of synthesizing 1-benzyl-3-benzoylurea derivatives was recommended without using reflux heating, and in the future, researchers must find a better approach to get a better yield. Keywords: 1-benzyl-3-benzoylurea derivatives, synthesis, method comparison, reflux 2021-11-30T00:00:00Z http://localhost:8080/xmlui/handle/123456789/7330 Title: Molecular Docking of Mangostin and Sinensetin Derivatives on SUR1-Pancreatic KATP Channel Target as Antidiabetic Authors: Kris Prasetyanti, Intan; Sukardiman, Sukardiman; Suharjono Abstract: Abstract Background: Diabetes Mellitus (DM) is a complex chronic disease characterized by increased blood glucose. The incidence of this disease is rising, especially type 2 diabetes which is caused by insulin resistance in the body. SUR1-Pancreatic KATP Channel is a receptor as an antidiabetic target because its inhibition process can increase insulin production so that it can reduce blood glucose in people with type 2 diabetes. Objective: This study aims to identify the in-silico activity of the SUR1-Pancreatic KATP Channel macromolecules. Methods: Identification of macromolecular binding sites using Protein Plus software, then carried out molecular docking using AutoDock software, where the formed molecular interactions are further identified using the BIOVIA Discovery Studio software. Results: After determining the macromolecular binding site, the RMSD value was 1.253, allowing for further molecular docking. Molecular docking showed that the Ligands of mangostin (α, β, γ-mangostin) and sinensetin derivatives had a good affinity, namely α-mangostin -6,31 kcal/mol; β-mangostin -5.78 kcal/mol; γmangostin -6.17 kcal/mol and sinensetin -4.75 kcal/mol. Conclusion: The affinity sequence in the docking process for the SUR1 KATP channel macromolecules is α-mangostin > γ-mangostin > β-mangostin > sinensetin. The highest affinity for the docking process on the macromolecule SUR1 KATP channel was α-mangostin with a value of ΔG - 6.31 kcal/mol Ki 23.65 μM. Keywords: mangostin derivatives, sinensetin, in-silico SUR1 KATP channel, antidiabetes 2021-11-30T00:00:00Z