http://localhost:8080/xmlui/handle/123456789/4829 287-578 2026-04-14T21:02:26Z http://localhost:8080/xmlui/handle/123456789/4881 Title: Reply to H. Raeisi-Dehkordi et al. 2021-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/4878 Title: Letter to the Editor on "Systematic Review of Diets Enriched in Oleic Acid and Obesity" 2021-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/4877 Title: Potential Roles of Adipocyte Extracellular Vesicle–Derived miRNAs in Obesity-Mediated Insulin Resistance Authors: Kim, Yujeong; Kim, Ok-Kyung Abstract: Recently, extracellular microRNAs (miRNAs) from adipose tissue have been shown to be involved in the development of insulin resistance. Here, we summarize several mechanisms explaining the pathogenesis of obesity-induced insulin resistance and associated changes in the expression of obesity-associated extracellular miRNAs. We discuss how miRNAs, particularly miR-27a, miR-34a, miR-141-3p, miR-155, miR210, and miR-222, in extracellular vesicles secreted from the adipose tissue can affect the insulin signaling pathway in metabolic tissue. Understanding the role of these miRNAs will further support the development of therapeutics for obesity and metabolic disorders such as type 2 diabetes 2021-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/4876 Title: Roles of the Polyphenol–GutMicrobiota Interaction in Alleviating Colitis and Preventing Colitis-Associated Colorectal Cancer Authors: Zhao, Yiying; Jiang, Qing Abstract: Accumulating evidence indicates that the gut microbiota can promote or inhibit colonic inflammation and carcinogenesis. Promotion of beneficial gut bacteria is considered a promising strategy to alleviate colonic diseases including colitis and colorectal cancer. Interestingly, dietary polyphenols, which have been shown to attenuate colitis and inhibit colorectal cancer in animal models and some human studies, appear to reach relatively high concentrations in the large intestine and to interact with the gut microbial community. This review summarizes the modulatory effects of polyphenols on the gut microbiota in humans and animals under healthy and diseased conditions including colitis and colitis-associated colorectal cancer (CAC). Existing human and animal studies indicate that polyphenols and polyphenol-rich whole foods are capable of elevating butyrate producers and probiotics that alleviate colitis and inhibit CAC, such as Lactobacillus and Bifidobacterium. Studies in colitis and CAC models indicate that polyphenols decrease opportunistic pathogenic or proinflammatory microbes and counteract disease-induced dysbiosis. Consistently, polyphenols also change microbial functions, including increasing butyrate formation. Moreover, polyphenol metabolites produced by the gut microbiota appear to have anticancer and anti-inflammatory activities, protect gut barrier integrity, and mitigate inflammatory conditions in cells and animal models. Based on these results, we conclude that polyphenol-mediated alteration of microbial composition and functions, together with polyphenol metabolites produced by the gut microbiota, likely contribute to the protective effects of polyphenols on colitis and CAC. Future research is needed to validate the causal role of the polyphenol–gut microbiota interaction in polyphenols’ anti-colitis and anti-CAC effects, and to further elucidate mechanisms underlying such interaction. 2021-01-01T00:00:00Z