DSpace Collection:http://localhost:8080/xmlui/handle/123456789/96972026-04-15T14:25:20Z2026-04-15T14:25:20ZRole of regulatory T cells and T helper 17 cells in the pathogenesis of hypertension: a reviewSakti Muliawan, HaryDwi Putra, SwastyaZulkifli Amin, HilmanWidyantoro, Bambanghttp://localhost:8080/xmlui/handle/123456789/97072025-02-21T04:48:36Z2024-01-01T00:00:00ZTitle: Role of regulatory T cells and T helper 17 cells in the pathogenesis of hypertension: a review
Authors: Sakti Muliawan, Hary; Dwi Putra, Swastya; Zulkifli Amin, Hilman; Widyantoro, Bambang
Abstract: The discovery of autoantibodies in artery samples from cadavers with hypertension
over 50 years ago suggested a potential link between the immune system and
hypertension. Since then, research exploring the role of the immune system in
hypertension has emerged. Animal studies have demonstrated a strong correlation
between regulatory T cells (Tregs) and T helper 17 (Th17) cells in hypertension
development, yet studies on human hypertension remain limited. Tregs produce
inhibitory cytokines such as interleukin (IL)-10 and transforming growth factor-β
to act as anti-inflammatory cells that protect against hypertension. In contrast,
Th17 cells, by producing IL-17A, function as pro-inflammatory cells that promote
hypertension. Recently, a subset of cells known as IL-17A+FOXP3+Treg cells have
been identified, which can produce IL-17 and act as inflammatory cells under certain
conditions. Understanding the basic mechanisms by which the immune system
influences hypertension could lead to targeted immunotherapies for hypertension in
the future. Thus, we highlighted the role of Tregs and Th17 cells in the development
of hypertension and their potential as targets for therapy. Our findings confirmed the
role of Tregs and Th17 cells in the pathogenesis of hypertension.
KEYWORDS hypertension, immune system, regulatory T cell, T helper 17 cell2024-01-01T00:00:00ZIntracranial dural arteriovenous fistula presenting like longitudinally extensive transverse myelitisYuliatri, NiaAyke Widjaya, IngridAditiara Wibawa, GibranHarlyjoy, AlphadentiSatyanegara, Satyanegarahttp://localhost:8080/xmlui/handle/123456789/97062025-02-21T04:48:46Z2024-01-01T00:00:00ZTitle: Intracranial dural arteriovenous fistula presenting like longitudinally extensive transverse myelitis
Authors: Yuliatri, Nia; Ayke Widjaya, Ingrid; Aditiara Wibawa, Gibran; Harlyjoy, Alphadenti; Satyanegara, Satyanegara
Abstract: Intracranial dural arteriovenous fistula (DAVF) that drains into spinal perimedullary
veins can generate longitudinally extensive transverse myelitis (LETM)-like lesion,
which often represents a significant diagnostic and therapeutic challenge. This is a case
report of a 50-year-old male referred with all extremity weaknesses. Despite receiving
high-dose intravenous steroids for suspected myelitis, no improvement was recorded.
Spinal imaging showed abnormal hyperintensity extending from the T6 vertebral level
to the medulla, and a flow void lesion from the cervicomedullary junction up to the
L3 level. Angiography confirmed a Cognard type V spinal DAVF, which was treated
with transarterial embolization of the feeding vessel. Follow-up angiography showed
complete occlusion of the fistula without any backflow. Flow voids are no longer
visible on MRI conducted 3 weeks post-procedure. Unfamiliarity with these disorders
often leads to delays in diagnosis and treatment. Therefore, it is essential to consider
intracranial DAVF as a differential diagnosis for LETM-like lesions.
KEYWORDS endovascular procedures, dural arteriovenous fistula, transverse myelitis2024-01-01T00:00:00ZMultimodal approach in the diagnosis and management of Eales disease: a case reportAndayani Adriono, GitalisaRasyid Mahfudz, SausanFauzi Triyoga, Ichsanhttp://localhost:8080/xmlui/handle/123456789/97052025-02-21T04:44:42Z2024-01-01T00:00:00ZTitle: Multimodal approach in the diagnosis and management of Eales disease: a case report
Authors: Andayani Adriono, Gitalisa; Rasyid Mahfudz, Sausan; Fauzi Triyoga, Ichsan
Abstract: Eales disease is a rare idiopathic occlusive retinal vasculitis with low prevalence in
the general population. Its infrequent occurrence limits diagnostic and treatment
guidelines, emphasizing the need for ongoing reports to establish effective protocols.
This case report describes a patient presenting with symptoms of bilateral retinal
vasculitis. Fundus examination revealed vitreous hemorrhage (VH) and peripheral
retinal vasculitis. Laboratory and imaging tests were performed to exclude differential
diagnoses, leading to Eales disease as the primary diagnosis. Pars plana vitrectomy,
panretinal laser photocoagulation, intravitreal anti-vascular endothelial growth
factor, and anti-tuberculosis therapy were administered. Long-term follow-up showed
satisfactory outcomes. This report suggested Eales disease to be a diagnosis of
consideration for ophthalmologists encountering male patients with recurrent VH.
Clinical suspicion, including appropriate laboratory testing and imaging, is essential
to developing a holistic approach to diagnosis and management, aiming to prevent
progression and achieve optimal visual outcomes.
KEYWORDS periphlebitis, rare diseases, retinal vasculitis, vitreous hemorrhage2024-01-01T00:00:00ZStand-alone middle meningeal artery embolization in chronic subdural hematoma patient presenting cognitive decline: a case reportGalindra, YusmahenryRilianto, BenyGusanto Kurniawan, RickyTri Prasetyo, Bambanghttp://localhost:8080/xmlui/handle/123456789/97042025-02-21T04:39:57Z2024-01-01T00:00:00ZTitle: Stand-alone middle meningeal artery embolization in chronic subdural hematoma patient presenting cognitive decline: a case report
Authors: Galindra, Yusmahenry; Rilianto, Beny; Gusanto Kurniawan, Ricky; Tri Prasetyo, Bambang
Abstract: Chronic subdural hematoma (cSDH) is a neurological disorder that commonly occurs in
the elderly with high morbidity and mortality. Current treatment for cSDH consists of
conservative therapy, surgical evacuation, and endovascular therapy, or a combination
of all the methods. Endovascular therapy for cSDH management involving middle
meningeal artery embolization (MMAE) has become a promising therapeutic option
for clinicians as it offers a minimally invasive, safe, and effective choice with a low
recurrence rate. MMAE using particles can also be performed in frail elderly patients
who cannot undergo large craniotomy procedures. We presented a case of a subdural
hematoma patient with cognitive decline using a therapeutic strategy of stand-alone
MMAE, which resulted in cognitive function improvement.
KEYWORDS chronic subdural hematoma, cognitive impairment, MMA embolization2024-01-01T00:00:00Z