359 - 560 http://localhost:8080/xmlui/handle/123456789/9117 2026-04-09T00:49:14Z 2026-04-09T00:49:14Z -Wei Lin, Ting -Chiao Hu, Ya -Hsu Yang, Yao -Hsiu Chien, Yin -Chung Lee, Ni -Hui Yu, Hsin http://localhost:8080/xmlui/handle/123456789/9249 2024-12-18T07:11:11Z 2022-06-01T00:00:00Z

Title: CTLA-4 gene mutation and multiple sclerosis: A case report and literature review Authors: -Wei Lin, Ting; -Chiao Hu, Ya; -Hsu Yang, Yao; -Hsiu Chien, Yin; -Chung Lee, Ni; -Hui Yu, Hsin Abstract: Abstract We reported a patient with autoimmunity (multiple sclerosis), immunodeficiency (hypogammaglobulinemia with severe infections), enteropathy (diarrhea with intestinal inflammation), splenomegaly, lymphadenopathy and lymphocytic infiltration of nonlymphoid organs (lung, gut and brain). The patient was found to have a heterozygous mutation in cytotoxic T lymphocyte antigen-4, and had excellent response to abatacept.

2022-06-01T00:00:00Z Pe´rez-Garcı´a, Felipe Angeles Jime´nez-Sousa, Maria Go´mez-Sa´nchez, Esther Gonzalo-Benito, Hugo Ferna´ndez-Rodrı´guez, Amanda Lorenzo-Lo´pez, Mario http://localhost:8080/xmlui/handle/123456789/9246 2024-12-18T07:07:26Z 2022-06-01T00:00:00Z

Title: CEACAM7 polymorphisms predict genetic predisposition to mortality in post-surgical septic shock patients Authors: Pe´rez-Garcı´a, Felipe; Angeles Jime´nez-Sousa, Maria; Go´mez-Sa´nchez, Esther; Gonzalo-Benito, Hugo; Ferna´ndez-Rodrı´guez, Amanda; Lorenzo-Lo´pez, Mario Abstract: Abstract We carried out a retrospective exploratory study on 173 patients who underwent major surgery and developed septic shock after surgery. Our findings suggest that CEACAM7 rs1001578, rs10409040, and rs889365 polymorphisms could influence septic shock-related death in individuals who underwent major surgery

2022-06-01T00:00:00Z -Yin Lin, Kuan -Ying Wu, Pei Da Liu, Wang- -Yun Sun, Hsin -Min Hsieh, Szu Huei Sheng, Wang- http://localhost:8080/xmlui/handle/123456789/9245 2024-12-18T07:06:12Z 2022-06-01T00:00:00Z

Title: Effectiveness of COVID-19 vaccination among people living with HIV during a COVID-19 outbreak Authors: -Yin Lin, Kuan; -Ying Wu, Pei; Da Liu, Wang-; -Yun Sun, Hsin; -Min Hsieh, Szu; Huei Sheng, Wang- Abstract: Abstract COVID-19 vaccination is recommended for at-risk populations, but the vaccine effectiveness in people living with HIV (PLWH) remains incompletely understood. Here we demonstrate that COVID-19 vaccination was clinically effective among PLWH during the outbreak setting with a low endemicity of COVID-19 where non-pharmaceutical interventions were strictly implemented

2022-06-01T00:00:00Z Chou, Shyun Hadano, Shinichiro Kojima, Atsushi Yorisaki, Mario Yasuda, Masaru Ike, Kazunori http://localhost:8080/xmlui/handle/123456789/9242 2024-12-18T07:03:46Z 2022-06-01T00:00:00Z

Title: Genetic characterization of Trichomonas gallinae (Rivolta, 1878) in companion birds in Japan and the genotypical relationship in the Asia region Authors: Chou, Shyun; Hadano, Shinichiro; Kojima, Atsushi; Yorisaki, Mario; Yasuda, Masaru; Ike, Kazunori Abstract: Abstract Background/purpose: Avian trichomonosis is a parasitic infection that affects a wide range of avian species, including free-ranging and pet birds worldwide, and Trichomonas gallinae has been considered as the only causative agent for decades. The sequence of the 5.8S ribosomal RNA with internal transcribed spacer (ITS) regions was widely used for identifying genotypes and determining inter-specific and intra-specific diversity. Moreover, the sequence of Fe-hydrogenase (FeHyd) was proposed as the second genetic marker for providing improved resolution of strain subtyping discrimination. Though the correlation between genetic variability and strain virulence is controversial, FeHyd analyses seemed to be useful to investigate the host or geographic origin of isolates. This study aimed to investigate the genetic characteristics of avian Trichomonas spp. Methods: Forty-seven oral swabs and crop lavage fluids were collected from 9 avian genera, which were diagnosed as Trichomonas-positive by microscopy in animal hospitals in Japan,were analyzed. Results: Genetic analysis of clonal isolates revealed the prevalence of the single genotype, ITS-OBT-Tg-1, by ITS region analysis, while two different subtypes, A2 and novel A3, were suggested by FeHyd gene analysis among Japanese companion birds. Phylogenetic analyses of available ITS sequences obtained from the Asia region (China, Iran, Iraq, and Saudi Arabia) were also preformed, revealing endemic ITS-OBT-Tg-1, ITS-OBT-Tg-2, ITS-OBT-Ttl-1, genotype III, and Saudi Arabia’s unique lineages. Furthermore, ITS-OBT-Tg-2 predominance in these countries indicates different strains origination from Japan. Conclusion: This is the first report of the genetic characterization of T. gallinae in Japan with discovery of novel subtype A3

2022-06-01T00:00:00Z