DSpace Community:http://localhost:8080/xmlui/handle/123456789/89482026-04-08T21:38:27Z2026-04-08T21:38:27ZCulture-negative orthopedic implant-associated infection due to Mycoplasma hominis: A case reporthttp://localhost:8080/xmlui/handle/123456789/122382025-07-19T04:00:08Z2025-03-01T00:00:00ZTitle: Culture-negative orthopedic implant-associated infection due to Mycoplasma hominis: A case report2025-03-01T00:00:00ZOseltamivir-resistant influenza in a fatal immunocompromised adulthttp://localhost:8080/xmlui/handle/123456789/122372025-07-19T03:58:33Z2025-03-01T00:00:00ZTitle: Oseltamivir-resistant influenza in a fatal immunocompromised adult2025-03-01T00:00:00ZUnanticipated cytotoxicity of fusidic acid in antibiotic-loaded hydrogelJiang, Jing-GuChen, Yu-ChunChen, Yu-ChunJiang, Ni-EnLiao, Chun-HsingChang, Chih-Hunghttp://localhost:8080/xmlui/handle/123456789/122362025-07-19T03:50:30Z2025-02-01T00:00:00ZTitle: Unanticipated cytotoxicity of fusidic acid in antibiotic-loaded hydrogel
Authors: Jiang, Jing-Gu; Chen, Yu-Chun; Chen, Yu-Chun; Jiang, Ni-En; Liao, Chun-Hsing; Chang, Chih-Hung
Abstract: This study evaluated the cytotoxicity of fusidic acid-loaded HA hydrogels on different cell types. Results show
significant cytotoxicity, especially at concentrations above 0.1 %, with MC3T3 cells being the most sensitive.
These findings highlight the importance of considering cell-specific responses and cytotoxic effects when
designing antibiotic-loaded hydrogels for biomedical applications.2025-02-01T00:00:00ZThe therapeutic impact of maximum chemotherapy possession days during three consecutive months in non-tuberculous mycobacterial lung disease: A real-world experienceWang, Ping-HuaiWei, Yu-FengLiu, Chia-JungChen, Chung-YuLin, Shu-WenPan, Sheng-WeiWang, Su-Meihttp://localhost:8080/xmlui/handle/123456789/122352025-07-19T03:45:41Z2025-03-01T00:00:00ZTitle: The therapeutic impact of maximum chemotherapy possession days during three consecutive months in non-tuberculous mycobacterial lung disease: A real-world experience
Authors: Wang, Ping-Huai; Wei, Yu-Feng; Liu, Chia-Jung; Chen, Chung-Yu; Lin, Shu-Wen; Pan, Sheng-Wei; Wang, Su-Mei
Abstract: Purpose: Adherence to guideline recommendations in the treatment of non-tuberculous mycobacterial lung disease (NTM-LD) is often difficult. Thus, this study aimed to investigate the impact of the integrity of NTM-LD
treatment on treatment outcomes.
Materials and methods: The participants were screened from the National Taiwan University Hospital-Integrative
Medical Database (NTUH-iMD) and the Taiwan National Health Insurance Research Database (NHIRD). The
longest treatment duration during 3 consecutive months was defined as maximum chemotherapy possession days
(MCPDs) and was categorized as low (28–55 days), medium (56–90 days), and maximum (≥91 days). We
analyzed microbiological cure and 3-year mortality using MCPDs.
Results: Low, medium, and maximum MCPD groups had 83 (19.2 %), 94 (21.8 %), and 255 (59.0 %) participants
in the NTUH-iMD cohort (N = 432) and 1203 (26.5 %), 1251 (27.6 %), and 2084 (45.9 %) participants in the
NHIRD cohort (N = 4538), respectively. In the NTUH-iMD cohort, multivariable analysis showed that adjusted
hazard ratios (aHRs) of 3-year mortality were 0.51 (95 % CI: 0.29–0.90) and 0.29 (0.18–0.49) in medium and
maximum MCPD groups compared with the low MCPD group. The trends of survival benefit by maximum MCPDs
were also found in the NHIRD cohort. The maximum MCPD group had 45.9 % participants with microbiologic
cure, which was significantly higher than in medium and low MCPD groups (27.7 % and 4.0 %, respectively; p <
0.001).
Conclusion: Maximum MCPD for NTM-LD increased microbiological cure and reduced 3-year mortality by 71 %
compared with low MCPD group. Maintaining NTM-LD treatment integrity as possible might positively impact
disease outcomes.2025-03-01T00:00:00Z