http://localhost:8080/xmlui/handle/123456789/8913 2026-04-18T18:14:31Z 2026-04-18T18:14:31Z Yamin, Muhammad Salim, Simon Syahrir Azizi, Mohamad Rusdi, Lusiani Wisaksono Sudoyo, Aru Amanda Putri, Anneira http://localhost:8080/xmlui/handle/123456789/9104 2024-12-16T03:41:46Z 2023-10-01T00:00:00Z

Title: Advancing The Cardiovascular Care in Cancer Patients on Chemotherapy Authors: Yamin, Muhammad; Salim, Simon; Syahrir Azizi, Mohamad; Rusdi, Lusiani; Wisaksono Sudoyo, Aru; Amanda Putri, Anneira Abstract: ABSTRACT Cardiotoxicity associated with chemotherapy, also known as Cancer Therapy-Related Cardiac Dysfunction (CTRCD), affects 10% of patients undergoing chemotherapy and is the most undesirable side effect of chemotherapy. Over time, it is anticipated that there would be an increase in the number of cancer patients receiving treatments that could harm their cardiovascular systems. Physicians should choose whether to continue, halt, delay, or reduce the dose of chemotherapeutic drugs to reduce the impact of cardiotoxicity. Cardiotoxicity screening and diagnosis need a variety of methods, primarily echocardiography to evaluate Left Ventricular Ejection Fraction (LVEF) and Global Longitudinal Strain (GLS). Depending on the clinical state, these procedures may be carried out prior to, during, or following chemotherapy. It’s critical to reduce cardiovascular risk factors and offer advice on leading a healthy lifestyle before giving cancer patients medicines. There are a lot of cancer treatment facilities all around the world that don’t have evidence-based perspective cardiotoxicity scores to stratify the risk of cardiovascular problems caused by cancer therapy. Additionally, comorbid conditions like diabetes and hypertension are frequently present in cancer patients, which can have a significant impact on clinical outcomes and cancer treatment. Therefore, this article aims to discuss assessment methods, clinical practice guidance, and prevention of CTRCD. Keywords: cardiac disease, cardiotoxicity, CTRCD, chemotherapy, cancer

2023-10-01T00:00:00Z Ardani, Yanuar Achmad, Ibrahim Faisal, Edward Poespitasari, Vinandia I. Putranto, Rudi Shatri, Hamzah http://localhost:8080/xmlui/handle/123456789/9102 2024-12-16T03:39:17Z 2023-10-01T00:00:00Z

Title: The Effect of Music Therapy for Improving Quality of Life in Patients with Cancer Pain: An Evidence Based Case Report Authors: Ardani, Yanuar; Achmad, Ibrahim; Faisal, Edward; Poespitasari, Vinandia I.; Putranto, Rudi; Shatri, Hamzah Abstract: ABSTRACT Background: Music therapy is a frequently used complementary and creative arts treatment in psychosocial cancer care. Particularly in advanced cancer populations and palliative care, music therapy has recently received high attention in both research and clinical care. This evidence-based case report is aimed to assesed the effect of music therapy for improving quality of life in patients with cancer pain. Methods: the search was conducted on Pubmed, Cochrane Library, and EMBASE according to clinical question. The studies were selected based on inclusion and exclusion criteria. The selected study was critically appraised. Results: All selected studies significantly showed effectiveness of music therapy towards quality of life in cancer patient. Conclusion: Music therapy might be beneficial adjuvant for cancer patients. Keywords: Music therapy, cancer, quality of life, pain.

2023-10-01T00:00:00Z Gilberth Ivano Kalaij, Ayers Syahrir Azizi, Mohamad Pramudita, Angga http://localhost:8080/xmlui/handle/123456789/9101 2024-12-16T03:34:37Z 2023-10-01T00:00:00Z

Title: Diagnostic Accuracy of Emergency Ultrasonography Compression by Non-Radiologists or Cardiologists for Diagnosis of Deep Vein Thrombosis in Lower Extremity: An Evidence-Based Case Report Authors: Gilberth Ivano Kalaij, Ayers; Syahrir Azizi, Mohamad; Pramudita, Angga Abstract: ABSTRACT Background: Deep vein thrombosis (DVT) is a medical condition with dangerous complications including lung thromboembolism which can cause death. However, the disease is often neglected, leading to delays in diagnosis and treatment. Patients with lower extremity DVT clinical signs and symptoms usually cause diagnostic dilemmas, specifically for general practitioners (GP). Various diagnostic strategies have been proposed to diagnose DVT although they still have several limitations. Therefore, emergency compression US by nonradiologists or cardiologists needs to be further considered as a fast and accurate alternative. This study is aimed to analyze the potency of emergency compression US by non-radiologists or cardiologists to diagnose DVT in the lower extremity. Methods: A comprehensive literature search was conducted through PubMed, Scopus, and Cochrane Library. The articles were screened based on predetermined inclusion and exclusion criteria with the keywords emergency, general practitioners, compression US, and DVT. Critical appraisal was performed using the Oxford CEEBM Critical Appraisal Tools for Diagnostic studies criteria. Results: This study analyzed a total of five cross-sectional studies and one prospective cohort. The emergency compression US performed by general practitioners and emergency physicians had a sensitivity of 86-93% and specificity of 90-97.1%. This analysis produced reliable results for diagnosing DVT in bedside settings compared to compression or doppler US performed by experts. Conclusion: Emergency compression US performed by general practitioners and emergency physicians had great potential to be a fast and accurate method for diagnosing and excluding DVT in lower extremities. However, standardized training is necessary to produce the highest diagnostic accuracy. Keywords: Compression US, emergency physician, diagnosis, deep vein thrombosis, Lower extremity

2023-10-01T00:00:00Z Yadi Permana, Muhammad Sarwanti, Sarwanti Fauziah, Siti http://localhost:8080/xmlui/handle/123456789/9098 2024-12-16T03:32:00Z 2023-10-01T00:00:00Z

Title: Effectivity of Bromocriptine Administration Towards Prolactin Positive Breast Cancer Receiving Anthracycline-Based Chemotherapy: A Literature Review Authors: Yadi Permana, Muhammad; Sarwanti, Sarwanti; Fauziah, Siti Abstract: ABSTRACT Breast cancer is among the deadliest gynecology cancers in the world. However, the management of advancedstage breast cancer is often harder as a result of chemoresistance. This review aimed to discover the effect of bromocriptine on prolactin-positive breast cancer patients who received anthracycline-based chemotherapy. It is known that anthracycline works by inhibiting topoisomerase IIα (TOP2A), forming free radicals, binding DNA, and altering cell homeostasis, hence stopping the cell cycle and inducing cell death. However, reduction of TOP2A expression and increased glutathione s-transferase (GST) and ATP-binding cassette (ATP) membrane activity increase anthracycline efflux from the cell membrane, hence reducing its effectivity. Prolactin is one of the most common chemoresistance agents whose complex with its receptor will induce JAK/STAT pathway to increase GST. The regulation of Bcl-2 and ERK was also determined by prolactin. Bromocriptine is an agonist of the D2 dopamine receptor that inhibits adenyl cyclase and a D1 dopamine weak antagonist. Bromocriptine could reduce prolactin serum and receptors in various cases. Some studies have found that bromocriptine could improve the effectiveness of chemotherapy regimens, including cancer-related hyperprolactinemia, breast cancer that underwent cisplatin, and taxanes. Therefore, bromocriptine offers potential as it could improve outcomes and reduce resistance in prolactin-positive breast cancer patients who are administered anthracycline-based neoadjuvant chemotherapy. Keywords: breast cancer, bromocriptine, chemotherapy, prolactin, receptor

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