http://localhost:8080/xmlui/handle/123456789/8838 2026-04-18T15:25:28Z 2026-04-18T15:25:28Z Herardi, Ryan Syam, Ari Fahrial Fauzi, Achmad Rinaldi, Ikhwan Sandra, Sharon Arvant, Anisya Zakiyyahaya http://localhost:8080/xmlui/handle/123456789/12280 2025-07-22T02:09:47Z 2025-04-01T00:00:00Z

Title: Role of Gastric Acid Suppression Therapy in Erosive Esophagitis: From H2 Receptor Antagonists, Proton Pump Inhibitors, to Potassium-Competitive Acid Blockers Authors: Herardi, Ryan; Syam, Ari Fahrial; Fauzi, Achmad; Rinaldi, Ikhwan; Sandra, Sharon; Arvant, Anisya Zakiyyahaya Abstract: Erosive esophagitis (EE) is an inflammation of the esophageal mucosa resulting from gastric and duodenal acid reflux, affecting approximately 55% of gastroesophageal reflux disease (GERD) patients in Indonesia. Effective acid suppression is essential for mucosal healing and symptomatic relief. Histamine-2 receptor antagonist (H2RA) was initially used for standard treatment for GERD, including EE, reducing gastric acid secretion by blocking H2 receptors. However, their efficacy is limited by inadequate acid suppression. Proton pump inhibitors (PPIs) became the mainstay therapy due to their stronger and longer-lasting acid suppression. Although PPIs have been proven to be quite effective, they have several limitations, including slow onset and inability to provide sustained acid suppression over a full 24-hour period. In recent years, Potassium-competitive acid blockers (PCAB) have become known as a category of drugs that effectively suppress gastric acid production, through a slightly different mechanism, and have advantages over PPIs, including faster onset and longer time of action. Both PPIs and PCABs can be used as therapy for patients with EE. PCABs are more recommended, especially in patients with severe grades of EE. H2RAs may still be considered in patients who have already received PPI therapy but continue to experience unresolved nocturnal acid symptoms.

2025-04-01T00:00:00Z Pandapotan, Roy Akur Syafitri, Anissa Setiawan, Andre Gunawan, Burhan Citra, Nathalia Gracia Bierhuijs, Josephine Alicia Titus, Johana http://localhost:8080/xmlui/handle/123456789/12278 2025-07-22T02:07:15Z 2025-04-01T00:00:00Z

Title: Early Enteral Feeding Versus Total Parenteral Feeding After Surgery in Severe Acute Pancreatitis: An Evidence-Based Case Report Authors: Pandapotan, Roy Akur; Syafitri, Anissa; Setiawan, Andre; Gunawan, Burhan; Citra, Nathalia Gracia; Bierhuijs, Josephine Alicia; Titus, Johana Abstract: Background: Acute pancreatitis is a self-limiting inflammatory disease that in some cases may lead to severe acute pancreatitis. To prevent this development, multimodal management, including nutritional management, is used in treating acute pancreatitis patients. The controversy between parenteral and enteral feeding has led to major debate. This case report aims to assess which method has better outcomes based on multiple cases of organ failure, inflammatory response, and length of hospital stay. Methods: A 46-yearold male presented to the Emergency Department of our hospital with acute abdominal pain, nausea, and vomiting, 12 h before admission. Based on physical and further examination, the patient was diagnosed with severe acute pancreatitis and underwent a necrotomy procedure. Articles from multiple databases were obtained and assessed using the Cochrane Collaboration Risk of Bias tool. The articles were analyzed using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and a forest plot model. Effect size quantification for continuous and categorical variables was analyzed using continuous and binary random effect models, respectively. Results: Seven articles were obtained after exclusion and review. A total of 491 patients with acute/severe acute pancreatitis were assessed. These seven articles conclude that enteral nutrition has advantages over parenteral nutrition. Conclusion: Our study concluded that early enteral feeding provides better clinical improvement, reduced lipase enzyme levels, and shortened length of hospital stay

2025-04-01T00:00:00Z Darmawan, Guntur Arshad, Anwar Samhari bin Mat Wibowo, Suryo Anggoro Kusumo http://localhost:8080/xmlui/handle/123456789/12276 2025-07-22T02:04:00Z 2025-04-01T00:00:00Z

Title: Successful Ultrasound-Guided Dry Needling for Treatment of Piriformis Syndrome Authors: Darmawan, Guntur; Arshad, Anwar Samhari bin Mat; Wibowo, Suryo Anggoro Kusumo

2025-04-01T00:00:00Z Herwanto, Velma Lie, Khie Chen Sinto, Robert Nainggolan, Leonard http://localhost:8080/xmlui/handle/123456789/12273 2025-07-22T02:01:49Z 2025-04-01T00:00:00Z

Title: Subphenotypic Classification of Immune Response in Sepsis: Predicting Mortality and Guiding Future Personalized Immunotherapy Authors: Herwanto, Velma; Lie, Khie Chen; Sinto, Robert; Nainggolan, Leonard Abstract: The most recent definition of sepsis highlights the dysregulation of the host’s immune response to infection, which varies between individual hosts, with patients predominantly presenting with either hyperinflammation, immunoparalysis, or a combination of both states. Therefore, management strategies must be tailored to accommodate the heterogeneity of patients with sepsis, as these conditions are associated with distinct prognoses and therapeutic approaches. Identification of the immune response in patients with sepsis can be achieved through advanced techniques, such as gene expression profiling or, more simply, through a subphenotypic approach. This article introduces a subphenotypic classification of the sepsis immune response into macrophage activationlike syndrome (MALS), where pathological macrophage activation leads to excessive hyperinflammation, immunoparalysis, or neither. Patients are classified using serum ferritin levels and monocyte HLA-DR expression, which is assessed using peripheral blood. This classification demonstrates significant differences in survival across groups, which is attributed to their distinct underlying biological processes. Immunotherapeutic options also differ for these three groups. In the future, such immune response classifications will be valuable in sepsis management algorithms for personalized prognostication and therapy

2025-04-01T00:00:00Z