http://localhost:8080/xmlui/handle/123456789/8606 2026-04-16T05:45:29Z 2026-04-16T05:45:29Z Hazae, Bassam A. Wardhani, Puspa Albadwi, Fatima http://localhost:8080/xmlui/handle/123456789/8750 2024-12-02T07:43:31Z 2024-09-01T00:00:00Z

Title: Abnormalities in Hemostatic Parameters Related to Hemodialysis in End-stage Kidney Pathology: A Narrative Review Authors: Hazae, Bassam A.; Wardhani, Puspa; Albadwi, Fatima Abstract: Chronic kidney disease (CKD) is a progressively prevalent global health issue. During the initial phases of the condition, CKD is commonly linked to a tendency for excessive blood clotting. While in the end-stage of disease, patients undergoing hemodialysis have a multitude of hemostatic abnormalities. These include prolonged bleeding time, altered platelet count, prolonged PT and aPTT, elevated FDPs and D-dimer, dysregulated vWF activity, and abnormal thrombin generation. These changes result from a combination of uremic toxicity, endothelial dysfunction, inflammatory states, and the effects of the hemodialysis procedure itself. Understanding these mechanisms is crucial for managing and mitigating the bleeding and thrombotic risks in this patient population. This review aims to systematically investigate the effects of hemodialysis on key hemostasis parameters in CKD patients

2024-09-01T00:00:00Z Islamia, Mila Fauzi, Abul Prasetiawaty, Eka http://localhost:8080/xmlui/handle/123456789/8749 2024-12-02T07:39:50Z 2024-09-01T00:00:00Z

Title: Effect of Conservative Vs Surgical Therapy on the Quality of Life of Patients with Maxillofacial Trauma: A Systematic Review Authors: Islamia, Mila; Fauzi, Abul; Prasetiawaty, Eka Abstract: Background: Selecting the best treatment strategy for maxillofacial trauma patients has grown challenging as a result of the continuous discussion on how different therapies affect these patients' quality of life. The purpose of this research is to methodically evaluate how conservative care and surgical care affect patients with maxillofacial trauma's quality of life. Methods: A systematic search was undertaken using PubMed, Cochrane Library, and Wiley Online Library to locate the most recent 20 years of research comparing the effects of various treatments on the quality of life of patients with maxillofacial injuries. We also looked through relevant researchers' references to find further studies. Articles were selected by applying a search strategy based on the Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA) guidelines. Results: This systematic review comprised 9 comparison studies with 944 individuals in total. The findings show that patients with maxillofacial trauma had lower quality of life initially, but that after receiving therapy, their quality of life increased to varying degrees, depending on the type of treatment. Conclusion: The majority of research revealed that patients who received MMF or ORIF did not significantly vary in terms of quality of life; however, those who were treated conservatively reported a notable improvement when compared to those who received surgical treatment (MMF/ORIF).

2024-09-01T00:00:00Z Nurcahyani, Icha Dian Amiruddin, Ridwan Thamrin, Yahya Wahiduddin Syam, Aminuddin Jafar, Nurhaedar Mallongi, Anwar http://localhost:8080/xmlui/handle/123456789/8715 2024-12-02T04:05:18Z 2024-09-01T00:00:00Z

Title: Obstacles to the Complementary Feeding Assistance Program for Stunted Children Aged 6-24 Months: A Systematic Review Authors: Nurcahyani, Icha Dian; Amiruddin, Ridwan; Thamrin, Yahya; Wahiduddin; Syam, Aminuddin; Jafar, Nurhaedar; Mallongi, Anwar Abstract: Stunting is a condition of stunted physical and cognitive growth caused by malnutrition during the development of children under five. UNICEF and WHO recommendations stipulate exclusive breastfeeding for 6 months and breastfeeding for up to two years. Apart from that, it is very important to provide complementary foods for breast milk for 6-23 months. The aim of the research is to determine the obstacles to the Complementary Feeding assistance program for stunted children aged 6-24 months. The method used is a Systematic Literature Review. Health database with search engines Google Scholar, PubMed, Science Direch, ProQuest and Scinapse. The search strategy uses the keywords: Program Constraints, Complementary Feeding, Stunting and Baduta. Identifying research articles for 2017-2023 and using PRISMA flowcharts and literature eligibility criteria based on the PICOS framework. A total of 10,523 articles were identified. Five articles used cross sectional methods, three survey articles, one descriptive analysis article and one cohort article. There were 10 eligible articles that met the inclusion criteria. Based on the results of the identification of Complementary Feeding assistance programs for stunted children aged 6-24 months. There is a correlation between obstacles to the mentoring program related to non-optimal complementary feeding practices (accuracy, diversity and frequency), lack of knowledge and experience, obstacles in communication skills (delivering key messages), selfefficacy/working mothers, sanitation/environmental conditions, socio-economic, weak regulations and government programs including increasing community-based programs such as posyandu. If children aged 0-23 months receive inappropriate complementary foods, they are at high risk of stunting. Various obstacles to the Complementary Feeding assistance program will influence the program's emphasis on promoting children's growth and development to prevent stunting. Conclusion: the Complementary Feeding mentoring program is not optimal, due to various obstacles (specific and sensitive) faced in providing Complementary Feeding to stunted children aged 6-23 months.

2024-09-01T00:00:00Z Ervianti, Octarina Sasono, Wimbo Prastyani, Reni http://localhost:8080/xmlui/handle/123456789/8713 2024-12-02T04:03:27Z 2024-09-01T00:00:00Z

Title: The Effects of Melon Superoxide Dismutase and Gliadin on Glutathione Reductase (GSH) and Superoxide Dismutase (SOD) Levels in Blood Plasma and Vitreoretina in Diabetic Rat Model: A Literature Review Authors: Ervianti, Octarina; Sasono, Wimbo; Prastyani, Reni Abstract: Chronic hyperglycemia in diabetics causes microvascular damage through four mechanisms of biochemical changes, including activated protein kinase C (PKC) pathway, activated hexosamine pathway, increased polyol pathway, and increased advanced glycation end-products (AGEs), all of which will increase Reactive Oxygen Species (ROS) levels. ROS can damage proteins, nucleic acids, and lipids and hasten the onset of diabetes. ROS are produced in the presence of normal blood sugar levels, and the natural breakdown of glucose is controlled by insulin. Variables that regulate cellular respiration, including NAD-related substrates, oxygen, succinate, and antioxidant enzymes, modulate ROS levels and sustain cellular redox equilibrium. The conversion of superoxide anions into hydrogen peroxide, before subsequently metabolized into water by catalase and glutathione (GSH) peroxidase, is facilitated by the metalloprotein superoxide dismutase (SOD). Increased ROS levels can lead to diabetic complications, one of which is diabetic retinopathy. Melon superoxide dismutase (SOD) combined with gliadin (Glisodin®) is a potent antioxidant in counteracting free radicals that can reduce oxidative stress and prevent further cell death. Research related to the use of Glisodin® shows potential as an antioxidant agent with the hope of preventing diabetic complications

2024-09-01T00:00:00Z