http://localhost:8080/xmlui/handle/123456789/8299 2026-04-08T21:38:36Z 2026-04-08T21:38:36Z Khair Alddin Ibrahim, Saba http://localhost:8080/xmlui/handle/123456789/9608 2025-01-08T03:17:07Z 2023-01-01T00:00:00Z

Title: Assessment of Serum Irisin and Vaspin in Women with Polycystic Ovary Syndrome in Mosul City Authors: Khair Alddin Ibrahim, Saba Abstract: Patients with “polycystic ovary syndrome” (PCOS) may have changes in adipokine levels due to obesity rather than PCOS per se. This should be taken into account as there is a correlation between adipokine levels and BMI. The objective of the subsequent investigation was to measure serum levels of irisin and vaspin in women with PCOS. In the following study, overall, 140 sample size was selected for the evaluation. These 140 were divided into two groups in which 70 women were on the one group which was the intervention group, and 70 women were in control group. The control group of the study were the women who reportedly had regular and normal menstrual cycle. The results indicated high values of vaspin and irisin. The results of this study and previously published literature suggest that both adipocytokines are associated with high blood glucose levels and higher BMI, and finally, both values remain higher in women with PCOS. Vaspin and irisin could be considered as a biomarker for prognosis and therapy followup in patients with PCOS. Key words: Vaspin, Irisin, Insulin, Testosterone, LH, FSH, PCOS.

2023-01-01T00:00:00Z M. Alsaffar, Omar T. Al-Saffar, Maha S. Mahmood, Abdulsattar http://localhost:8080/xmlui/handle/123456789/9607 2025-01-08T03:15:51Z 2023-01-01T00:00:00Z

Title: Lisinopril-Induced CD34 Bone Healing Marker Authors: M. Alsaffar, Omar; T. Al-Saffar, Maha; S. Mahmood, Abdulsattar Abstract: Background: Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor that is commonly used to treat high blood pressure and heart failure. While it is generally well-tolerated, some studies have suggested that it may affect bone healing, suggesting that lisinopril treatment was associated with an increase in the CD34 bone healing marker in patients with tibial fractures. CD34 is a protein that is involved in the formation of new blood vessels and has been shown to play a role in bone healing. Methods: The study used 24 rabbits with artificially induced tibial bone fracture divided into 4 groups (6 rabbits each), the control group treated with distilled water and 3 groups treated with lisinopril. Each group were sacrificed for immunohistochemical study on 3 timepoints at day 7, 14, and 21. Results: Indicated that the lisinopril group had significantly higher levels of CD34 than the control group. Conclusion: While the results of this study suggest that lisinopril may have a positive effect on bone healing, more research is needed to confirm these findings and to determine the mechanisms by which lisinopril may affect bone healing. It is also important to note that lisinopril may have other potential side effects, and patients should discuss any concerns with their healthcare provider. Key words: Lisinopril, Bone healing, Inflammation, Bone injury, CD34

2023-01-01T00:00:00Z Kabir, Emranul Khan Noyon, M. R. O. Uzzaman, Monir http://localhost:8080/xmlui/handle/123456789/9606 2025-01-08T03:12:36Z 2023-01-01T00:00:00Z

Title: Computational and Pharmacokinetic Investigation of Some Heterocyclic Amide Derivatives as Cyclooxygenase Inhibitors: An In-Silico Approach Authors: Kabir, Emranul; Khan Noyon, M. R. O.; Uzzaman, Monir Abstract: The two most significant as well as historically important non-steroidal and anti-inflammatory medications (NSAIDs), aspirin and ibuprofen, are frequently used to treat fever, pain, and inflammation. By blocking the activity of cyclooxygenase (COX), it can prevent the production of prostaglandin. In an effort to examine the physiochemical and biological properties of some heterocyclic amide derivatives and quantum mechanical computations have been used to analyze the compounds. To clarify the thermochemical, molecular orbital, and equilibrium geometrical features in the gas phase, density functional theory (DFT) with the B3LYP/6- 31G basis set has been used. Binding affinities and modes of heterocyclic amide analogs have been investigated on human cyclooxygenase (COX-1 and COX-2) proteins (6Y3C and 5F19) using molecular docking as well as nonbonding interactions. Results from geometry and thermochemical analysis support the chemical sustainability of all the structures. Most of the compounds exhibited a significant affinity for binding to the receptor protein (5F19) than the standard drugs aspirin and ibuprofen. The improved pharmacokinetic features of certain derivatives with reduced acute oral toxicity were revealed by ADMET prediction. Overall, four heterocyclic amide analogs 3-6 were found to be more efficient in inhibiting COX- 2 (5F19) than COX-1 (6Y3C), suggesting that they may be useful as COX-2-related inflammation drug candidates. Key words: Cyclooxygenase (COX), Heterocyclic amide derivatives, Molecular Docking, ADMET.

2023-01-01T00:00:00Z N Dawood, Muthear A. Aldabbagh, Karam Alsarraf, Zahraa http://localhost:8080/xmlui/handle/123456789/9605 2025-01-08T03:12:41Z 2023-01-01T00:00:00Z

Title: Inflammatory Thyroid Changes Following Serotonin Receptor Blocking in Experimental Rats Authors: N Dawood, Muthear; A. Aldabbagh, Karam; Alsarraf, Zahraa Abstract: According to studies, a pathophysiological feature of schizophrenia may be a dysregulation of the inflammatory immune response. Conversely, antipsychotic medications have been found to have an immunosuppressive effect in patients with schizophrenia; however, this has not been consistently observed in different studies. The purpose of the following study is to compare the effects of risperidone with aripiprazole on thyroid function as it relates to inflammatory markers (CRP). This study was based on a randomized controlled trial. A total of thirty rats were recruited for the experiment and were kept in the artificial, and optimal environment. The rats were divided into three groups; each group has an equal number of rats which was 10 rats each. The first group was the control group which received the placebo, in the second group, there were 10 rats too, which was known as the risperidone group. Each rat received 20mg/kg/day through I/V. The third group is known as the aripiprazole group which received the drug from the intravenous route, 10mg/kg//day. In the results, the summarized values represented that all the mean values before and after the treatment remained less than 3.0. From the results and other evidence, it can be said that although the subjects who receive the following results do not require regular or frequent monitoring of thyroid hormones in long-term use and in the use of the drug in higher concentration there must be a check as long term use is associated with hyperthyroidism. Key words: Thyroid, FT3, FT4, Thyroxine, Tri-iodothyronine, Aripiprazole, Risperidone.

2023-01-01T00:00:00Z