http://localhost:8080/xmlui/handle/123456789/8271 2026-04-09T13:16:18Z 2026-04-09T13:16:18Z Pebriani, Mala Sumarny, Ros Arozal, Wawaimuli Eviarini, Prawitasari Ismaya, Nurwulan Adi http://localhost:8080/xmlui/handle/123456789/8331 2024-11-22T02:53:47Z 2024-02-01T00:00:00Z

Title: Potentially Inappropriate Medication (PIM) Prescribing According to Beers Criteria among Elderly Outpatients at Pasar Minggu Hospital, Jakarta Authors: Pebriani, Mala; Sumarny, Ros; Arozal, Wawaimuli; Eviarini, Prawitasari; Ismaya, Nurwulan Adi Abstract: Elderly patients generally have physiological changes that cause multipathological conditions, so they require several drugs to treat these conditions, it is necessary to evaluate the use of drugs to optimize the treatment of geriatric patients. Beers Criteria 2019 is a criteria that is commonly used to present Potentially Inappropriate Medication (PIM). This study aimed to examine the inaccuracy of prescription drugs in the elderly using Beer's criteria 2019. This research is an observational analytic study with a cross-sectional descriptive design. The Beer's 2019 criteria classify PIM into five categories. Data were taken retrospectively as many as 847 prescriptions met the inclusion criteria at the Pasar Minggu Hospital Outpatient Polyclinic. Data were analysed by Univariate and Bivariate. The results showed that from 847 prescriptions for geriatric patients, there are 160 prescriptions for geriatric patients who experienced PIM (18.89%). Percentage of PIM incidents by category; namely, category 1 was 29.17%, category 2 was 6.77%, category 3 was 44.79%, category 4 was 16.67%, and category 5 was 2.60%. The results of the analysis showed that there was a significant relationship between the number of drugs and Heart Failure and CAD with the incidence of PIM with a p value of 0.000 and 0.035. DM and Heart Failure are 2 diseases that significantly influence the incidence of PIM. This study concludes that the elderly are at risk for receiving potentially inappropriate medications.

2024-02-01T00:00:00Z Yunarto, Nanang Ismaya, Nurwulan Adi Reswandaru, Uud Nourma Hermiyanti, Evika Gumilang, Nabila Cahya Salina, Fitri http://localhost:8080/xmlui/handle/123456789/8326 2024-11-22T02:38:36Z 2024-02-01T00:00:00Z

Title: In vivo Study of Uric Acid Inhibitory of Catechin from Gambir (Uncaria gambir (Hunter) Roxb) in Male Rats Authors: Yunarto, Nanang; Ismaya, Nurwulan Adi; Reswandaru, Uud Nourma; Hermiyanti, Evika; Gumilang, Nabila Cahya; Salina, Fitri Abstract: Hyperuricemia is a metabolic disease characterized by high levels of uric acid in the blood. In silico studies of catechin compounds using molecular docking were able to inhibit the activity of the xanthin oxidase enzyme so that it could reduce uric acid levels. One of the native Indonesian plants that contains catechin is gambier (Uncaria gambir (Hunter) Roxb). This research aims to obtain the efficacy and safety of gambier leaf catechins in reducing uric acid levels. In vivo efficacy testing at doses of 20, 40, and 40 mg/Kg BW with allopurinol as a comparison and the safety of gambier leaf catechin in hyperuricemic male mice through macroscopic and microscopic examination of the liver and kidney organs. The results of research on determining catechin levels using HPTLC obtained levels of 96.06%. Gambier leaf catechin at doses of 20, 40, and 40 mg/Kg BW was able to reduce uric acid levels in the blood serum of mice. The higher the dose of catechin, the better the antihyperuricemia effect. In the results of the safety parameters, gambier leaf catechins, there were no specific abnormalities in the liver and kidneys of mice both macroscopically and microscopically. Based on research, it can be concluded that gambier leaf catechin has great potential as an anti-hyperuricemia drug and has good safety if consumed for a long time.

2024-02-01T00:00:00Z Hariutami, Desi Darmawati, Sri Permana, Atna Zuraida, Zuraida http://localhost:8080/xmlui/handle/123456789/8313 2024-11-22T01:52:30Z 2024-02-01T00:00:00Z

Title: The Effect of Different Solvents on the Content of Black Cumin Seed Extract (Nigella sativa) Authors: Hariutami, Desi; Darmawati, Sri; Permana, Atna; Zuraida, Zuraida Abstract: Seeds of black cumin (Nigella sativa L.), also called "black cumin," are an herbal plant from the Ranunculaceae family. The objective of this study was to determine the yield of black cumin seed extract using 96% ethanol, N-hexane, and ethyl acetate as solvents, as well as to determine the results of phytochemical screening tests and the active ingredient content using GCMS. The stages of the research included the extraction process, phytochemical screening test, and GCMS. The study's findings on the yield of black cumin seed extract using the three solvents showed that the solvent N-Hexane produced the highest yield, at 28.09 percent. Based on phytochemical screening tests, black cumin seeds were positive for containing secondary metabolites such as alkaloids, saponins, phenolic flavonoids, triterpenoids, steroids, and glycoxides. Other potential compounds vizhexadecenoic acid, ethyl ester, Methyl (8e,11e)-8,11- octadecadienoate, 12-octadecadienoic acid (z,z)-, Grape seed oil.

2024-02-01T00:00:00Z Isnenia Julaiha, Siti http://localhost:8080/xmlui/handle/123456789/8308 2024-11-22T01:38:36Z 2024-02-01T00:00:00Z

Title: Mother’s Knowledge of Expiration Dates, Beyond-Use Date (BUD), and Storage Conditions for Compounding and Non-Compounding Drugs Authors: Isnenia; Julaiha, Siti Abstract: Patients can obtain various pharmaceutical dosage forms, both compounded and non-compounded. The expired date is no longer a benchmark when the patient or pharmacist opens the primary packaging in preparation but uses the Beyond-Used Date (BUD). Beyond-used date (BUD) has a shorter time than the expiration date. Storage conditions in the household play an important role in the quality of the drug and its feasibility for consumption. This study aimed to compare knowledge about the expired date, BUD, and drug condition storage in two groups, compounding and noncompounding. This research was quantitative, with a cross-sectional design. The sample of this study was the mothers of pediatric patients who received outpatient treatment at one of the primary health centers. The sampling technique was carried out purposively. Data were collected through interviews in September-October 2021. The results of this study show that the respondents are predominantly in the range of 26-45 years, senior high school education, status as housewives, and insurance. The level of knowledge of both the non-compounding groups in the three aspects is greater than that of the compounding group. There is a significant difference in the compound and non-compounding groups in the knowledge of expired date (p=0.000) and BUD (p=0.000). There is no significant difference in knowledge of storage conditions (0.347). This study concludes that there is a significant difference in knowledge between the two groups in expired date and BUD, where the compounding group has greater good knowledge.

2024-02-01T00:00:00Z