http://localhost:8080/xmlui/handle/123456789/8035 2026-04-09T02:13:08Z 2026-04-09T02:13:08Z Samudra, Dian Widodo, Widodo Mardiana, Nunuk http://localhost:8080/xmlui/handle/123456789/9580 2025-01-08T02:09:56Z 2022-01-01T00:00:00Z

Title: Nephrotic Syndrome with Focal Segmental Glomerulosclerosis Histological Feature: A Case Report Authors: Samudra, Dian; Widodo, Widodo; Mardiana, Nunuk Abstract: Introduction: Nephrotic syndrome is a clinical syndrome of heavy proteinuria and hypoalbuminemia or hypoproteinemia. Renal biopsy is fundamental to assess not only the type but also the degree of disease activity. The overall prognosis and response to treatment often depend on the severity of histological lesions and their reversibility.1,2 Case Presentation: An eighteen years old man with nephrotic syndrome and planned for a kidney biopsy. This case showed a patient with swollen face (especially on the cheek). On Biopsy results showing the glomerulus proliferation of cells and mesangeal matrix, adhesions in (50%) glomerulus, focal sclerosis in some glomeruli, erythrocyte cells visible in the urinary space and thickening of the basement membrane in some glomeruli, partially atrophic tubules, visible erythrocytes in the tubular lumen. Conclusion: An eighteen years old man with nephrotic syndrome with cushing syndrome and hypokalemia who had a renal biopsy. The histological feature from the renal biopsy was focal segmental glomerulosclerosis. The underlying cause of FSGS is still unclear. Assessing the diagnosis and etiology become important to direct the subsequent clinical approach and therapy Key words: Nephrotic syndrome, Focal segmental glomerulosclerosis, Renal biopsy

2022-01-01T00:00:00Z Farid Rizk, Maulana Sugianto, Paulus Maria Maramis, Margarita Soetjipto, Soetjipto http://localhost:8080/xmlui/handle/123456789/9579 2025-01-08T02:00:50Z 2022-01-01T00:00:00Z

Title: Viral Meningoencephalitis Patient with Comorbid Major Depression with Psychotic Symptoms: A Case Report Authors: Farid Rizk, Maulana; Sugianto, Paulus; Maria Maramis, Margarita; Soetjipto, Soetjipto Abstract: Viral meningoencephalitis causes meninges and brain parenchyma inflammation, thus provoking significant morbidity and mortality. Clinical features include neurological and psychiatric symptoms depending on the brain involved, mild symptoms such as fever, headache, neck stiffness, and confusion, or severe symptoms such as seizures, weakness, hallucinations, and coma. Therefore, the clinical diagnosis and treatment of such cases are challenging to make. This case report describes an adult male patient suffering from viral meningoencephalitis with comorbid major depression with psychotic symptoms. The patient requires holistic management of meningoencephalitis with comorbid depression and neuropsychiatric symptoms that may occur in the long term. Key words: Viral meningoencephalitis, Comorbid, Depression

2022-01-01T00:00:00Z Airene Novianti, Dewintha Wardhani, Puspa http://localhost:8080/xmlui/handle/123456789/9578 2025-01-08T01:59:36Z 2022-01-01T00:00:00Z

Title: Massive Pleural Effusion with Adenosine Deaminase (ADA) Test Positive and COVID-19 Confirmed: A Case Report Authors: Airene Novianti, Dewintha; Wardhani, Puspa Abstract: A 26-year-old man complained of shortness of breath for 3 days before the hospital admission. The patient had a history of coughing up blood and had consumed alcohol and drugs. Decreased vesicular auscultation and dull percussion in the left lateral pulmo. Laboratory result showed increased neutrophil-lymphocyte ratio C-reactive protein, D-dimer, procalcitonin, ferritin, and decreased albumin level. Pleural fluid analysis indicated the presence of exudate, SARS-CoV-2 PCR positive, and increased ADA level to 43 U/L. Based on the examination results, we suspected that the etiology of the massive pleural effusion was tuberculous pleurisy, particularly due to increased ADA levels. The patient was diagnosed with COVID-19 pneumonia with massive pleural effusion and tuberculous pleurisy. Massive pleural effusion in SARS-CoV-2 infection is rare. Thus, laboratory modalities for massive pleural effusion diagnosis are needed to determine the etiology and effective treatment for the patient. ADA analysis could be considered as an initial examination in patients with pleural effusion during the wait for pleural fluid culture results. Key words: Pneumonia, COVID-19, Pleural effusion, Tb pleuritis, ADA test, Infectious disease

2022-01-01T00:00:00Z Butar Butar, Yosua Wardhani, Puspa http://localhost:8080/xmlui/handle/123456789/9577 2025-01-08T01:57:45Z 2022-01-01T00:00:00Z

Title: Thalassemia β Major in Confirmed Covid-19 Patient: A Case Report Authors: Butar Butar, Yosua; Wardhani, Puspa Abstract: The incidence of Thalassemia with confirmed Covid 19 is very rare. The aim of this study is to know the prognosis and evaluate the management of therapy in thalassemia β Mayor patients with COVID-19. This case study describes the progression of Thalassemia β Mayor with COVID 19 starting from how to establish the diagnosis of Thalassemia β Mayor and COVID 19 until how to treat thalassemia β Mayor patients with COVID-19 This case study result describes that COVID 19 aggravates thalassemia β Mayor. Infection can adversely affect thalassemia. Giving Blood transfusions must be done due to anemia in Thalassemia, but it will have an impact on the accumulation of iron in the body which will increase the severity of the infection. The administration of iron-chelation drugs is beneficial for Covid but on the other hand, it is contraindicated in Thalassemia patients. Key words: Thalassemia, Infection, Preventable Death, COVID-19.

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