http://localhost:8080/xmlui/handle/123456789/7726 2026-04-14T20:45:11Z 2026-04-14T20:45:11Z Perwitasari, Dyah Aryani Baroroh, Faridah Sari, Andriana Rachma, Putri http://localhost:8080/xmlui/handle/123456789/7962 2024-11-15T02:13:23Z 2023-11-01T00:00:00Z

Title: Interprofessional education applied in first-year and third-year health students: cross-sectional study Authors: Perwitasari, Dyah Aryani; Baroroh, Faridah; Sari, Andriana; Rachma, Putri

2023-11-01T00:00:00Z Caroline Ervina, Martha Pratama, Mohammad Rizki Fadhil Jessica, Maria Anabella http://localhost:8080/xmlui/handle/123456789/7960 2024-11-15T02:10:46Z 2023-11-01T00:00:00Z

Title: In silico study of the essential oil compounds of ginger and thyme on Coronavirus-2 receptors Authors: Caroline; Ervina, Martha; Pratama, Mohammad Rizki Fadhil; Jessica, Maria Anabella Abstract: Coronavirus-2 (SARS-Cov-2) is a virus that attacks the respiratory system and causes the Covid-19 pandemic. After the pandemic, prevention and appropriate therapy research continue to be carried out to anticipate the emergence of more dangerous viruses. In line with the culture of consuming herbs that has arisen due to the effects of the pandemic, in this study, an in silico study was carried out for essential oil compounds produced by ginger and thyme herbs which have been widely consumed by the public. The research aim to find the essential oil content that has the most potential as an antiviral against coronavirus-2. The moleculer docking method was carried out, including ligand preparation, receptor and method validation, and analysis of ligand-receptor binding interactions using the AutoDoc 4.2.6. As comparisons, remdesivir and favipiravir were used. The three components with the most potential based on the calculation of the free energy value, were determined by the ADMET parameters using the ADMETlab 2.0. The results showed that the three components in the essential oil exhibited better interactions when compared to remdesivir and favipiravir at the 3CL protease and spike glycoprotein receptors. The results of the in silico study and ADMET prediction test showed that of the three most potent compounds, α-farnesen was the most potent and safe to use .

2023-11-01T00:00:00Z Sabandar, Anna Helena Kasmiyati, Sri Djohan http://localhost:8080/xmlui/handle/123456789/7959 2024-11-15T02:05:07Z 2023-11-01T00:00:00Z

Title: The determination of antioxidant and lead content of hemiparasite Dendrophthoe vitellina (F. Muell) Tiegh on Nutmeg Authors: Sabandar, Anna Helena; Kasmiyati, Sri; Djohan Abstract: Mistletoe, a parasitic plant growing on nutmeg trees, is conventionally perceived as a parasitic entity with limited regard for its potential medicinal value. On the other hand, mistletoe has a remarkable potential source of valuable medicinal compounds, particularly in traditional healthcare, due to its secondary metabolites such as flavonoid, phenolic, ascorbic acid, and antioxidant activity. Nevertheless, both the host tree and the environment, like Pb, influence the adaptive responses of secondary metabolites. This study aimed to determine the secondary metabolites, such as flavonoids, phenolics, ascorbic acid, antioxidant activity, and Pb content in the leaves of D. vitellina and nutmeg (M. fragrans). The samples were obtained via maceration using ethanol. The spectrophotometric analysis method was used to measure several parameters, using particular reagents for phenolic compounds using Folin-Ciocalteu, flavonoids using AlCl3, and ascorbic acid using sulfosalicylic acid), antioxidant activity using DPPH, and Pb using the AAS method. The results indicated that D. vitellina possesses a higher concentration of flavonoid and phenolic compounds, followed by 3.36 ± 1.92 % (w/w) and 18.45 ± 2.35 % (w/w) respectively. Conversely, nutmeg had a significant ascorbic acid concentration of 3.99 ± 4.38 % (w/w). The significant presence of phenolics and flavonoids had a crucial role in the antioxidant activity seen in D. vitellina, which exhibited exceptionally potent antioxidant properties. All samples contain Pb, ranging from 0.09-2.10 µg/g, within the maximum allowable limits. Therefore, mistletoe is notable for being a reliable and encouraging plant species that can provide a natural supply of antioxidants and be safely used in traditional medicine.

2023-11-01T00:00:00Z Darsono, Lusiana Suherman, Jo Widowati, Wahyu Kusuma, Hanna Sari Widya http://localhost:8080/xmlui/handle/123456789/7958 2024-11-15T02:04:47Z 2023-11-01T00:00:00Z

Title: Anti-hyperlipidemic effect of mangosteen (Garcinia mangostana L.) peel extract in dyslipidemia-induced rats Authors: Darsono, Lusiana; Suherman, Jo; Widowati, Wahyu; Kusuma, Hanna Sari Widya Abstract: Dyslipidemia is due to an increase in blood lipid levels, which include cholesterol (CHOL), triglycerides (TG), and low-density lipoprotein (LDL). Since oxidative stress is the primary factor of dyslipidemia, it is strongly recommended that an antioxidant-based therapy be developed. Mangosteen is an antioxidant agent that exhibits free radical scavenging attributes and oxidation of low-density lipoprotein oxidatio’s protection. This study focused on determining the anti-hyperlipidemic and antioxidant effects of mangosteen peel extract (MPE) in dyslipidemia rats. Lipid profile: CHOL, TG, LDL, High-Density Lipoprotein (HDL), and Malondialdehyde (MDA) levels of dyslipidemia rats were assessed. High cholesterol was delivered to the rats for 4 weeks to induce dyslipidemia. The high cholesterol administration was stopped after rats encountered dyslipidemia. Subsequently, rats were given MPE 1000; 500; 250 mg/kg body weight (BW) daily for 14 days (initial treatment) and 28 days (subsequent treatment), normal control (normal feed), and negative control (dyslipidemia rats). Hematoxylin Eosin staining was used to observe the histology of liver and vascular endothelial tissue. After 28 days of treatment, the CHOL, TG, and LDL were critically declined by 1000 mg/kg MPE. MDA plasma level showed a decrease in all treatments. Mangosteen peel extract improved histological structure by reducing lipid accumulation in the hepatocyte cytoplasm. In conclusion, MPE showed anti-hyperglycemic and antioxidant activity in dyslipidemia-induced rats.

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