http://localhost:8080/xmlui/handle/123456789/7553 2026-04-09T01:13:08Z 2026-04-09T01:13:08Z Nuril Aliyah, Alma Aprili, Pingkan Agung Sagung Dyah Pramesti, Anak Dinda Saraya, Tarisya Laksatrisna Pide, Galuh Budi Sumartha, I Nengah Wongso, Luke Rahmadi, Mahardian Samirah, Samirah Zaki Bin Ramli, Muhammad Ardianto, Chrismawan http://localhost:8080/xmlui/handle/123456789/7566 2024-11-08T03:28:09Z 2023-08-02T00:00:00Z

Title: Effect of Fenofibrate as PPARα Agonist in Suppressing the Development of Oxaliplatin-Induced Peripheral Neuropathy via TRPA1 Modulation Authors: Nuril Aliyah, Alma; Aprili, Pingkan; Agung Sagung Dyah Pramesti, Anak; Dinda Saraya, Tarisya; Laksatrisna Pide, Galuh; Budi Sumartha, I Nengah; Wongso, Luke; Rahmadi, Mahardian; Samirah, Samirah; Zaki Bin Ramli, Muhammad; Ardianto, Chrismawan Abstract: Abstract Background: CIPN (Chemotherapy-induced Peripheral Neuropathy) primarily affects the sensory system and is accompanied by pain, autonomic dysfunction, and motor impairments. Alterations of intracellular second messengers at the supraspinal level in CIPN needed to be explored more. In addition, there is a lack of evidence regarding implications for the supraspinal area through the propagation of pain via the ascending pathway. Objective: In this study, we evaluated the effect of fenofibrate as a PPARα agonist in suppressing the development of CIPN. Methods: Twenty-four mice were distributed to the normal control group, neuropathy group, and neuropathy with the treatment of fenofibrate 75 and 150 mg/kg groups, resulting in 6 animals per group. Oxaliplatin was injected on days 0, 2, 4, and 6. The hot plate test was performed before the oxaliplatin administration and then continued on the 7th, 14th, and 21st days. Thalamus tissues were collected to measure the TRPA1 mRNA expression using qPCR. Results: Fenofibrate 75 mg/kg co-treatment with oxaliplatin tended to prevent the enhancement of oxaliplatin-induced thermal hyperalgesia in hind-paw withdrawal and rubbing responses. Furthermore, fenofibrate 75 and 150 mg/kg co-treatment with oxaliplatin significantly reduced the relative TRPA1 mRNA expression but did not modulate the relative BDNF mRNA expression in the thalamus. Conclusion: PPARα agonist has a potential effect in suppressing the development of CIPN. However, given the various perspectives on the role of neurotrophins in CIPN, additional non-clinical investigations, are needed to provide more insight into other mechanisms of CIPN and the role of PPAR agonists. Keywords: fenofibrate, oxaliplatin, peripheral neuropathy, PPARα agonist, TRPA1

2023-08-02T00:00:00Z Mariana Siregar, Nia Utam, Wahyu Prihhastuti Puspitasari, Hanni http://localhost:8080/xmlui/handle/123456789/7565 2024-11-08T03:24:14Z 2023-08-02T00:00:00Z

Title: Perspectives of Pharmacists, Doctors, and Nurses on Collaborative Management of Hypertension in Primary Health Centers Authors: Mariana Siregar, Nia; Utam, Wahyu; Prihhastuti Puspitasari, Hanni Abstract: Abstract Background: Puskesmas is a primary healthcare facility that conducts chronic disease management, such as hypertension. The role of pharmacists in team collaboration includes that of managerial and clinical pharmacies. However, doctors and nurses still need to be fully aware of the role of pharmacists, particularly in clinical pharmacies. Objective: This study aimed to determine the perspectives of pharmacists, doctors, and nurses on the collaborative management of hypertension in health centres across the Central Lombok Regency. Methods: observational qualitative method with a maximum variation sampling technique was used. Data saturation was achieved after interviewing 27 participants between April and June 2023. Participants were pharmacists, doctors, and nurses responsible for managing hypertension in the selected primary healthcare centers. Results: Five main themes were identified. The first was a perspective on pharmacists’ managerial and clinical pharmacy roles. Almost all participants agreed that pharmacists played more roles in ensuring the availability of hypertension drugs than clinical pharmacies. Four themes were derived from a conceptual framework related to team readiness to collaborate: cognitive, affective/relational, behavioral, and leadership aspects. In general, doctors and nurses need to be made aware of pharmacists' role in the area of clinical pharmacy; meanwhile, pharmacists need to improve their clinical pharmacy knowledge. Meanwhile, team collaboration has not run optimally because each team member works individually rather than as a team member. Conclusion: Pharmacists need to improve their clinical pharmacy role, be more involved in team collaborations, and be more engaged in team collaborations; efforts are required to prepare for team collaboration. Keywords: hypertension, perspective, pharmacist's role, team collaboration

2023-08-02T00:00:00Z Muin, Dona Satibi, Satibi Ari Kristina, Susi Suryo Prabandari, Yayi http://localhost:8080/xmlui/handle/123456789/7564 2024-11-08T03:22:02Z 2023-08-02T00:00:00Z

Title: Perception of Hospital Pharmacist on Working Performance in Yogyakarta Province, Indonesia Authors: Muin, Dona; Satibi, Satibi; Ari Kristina, Susi; Suryo Prabandari, Yayi Abstract: Abstract Background: Pharmacists support the success of hospital in efforts to improve people's quality of life then the performance measurement of pharmacists is carried out. Objectives: This study aimed to measure pharmacist performance based on the perception of pharmacists working in hospitals. Methods: Perception surveys were conducted with pharmacists working in public hospitals. The assessment was performed using a closed questionnaire that was proven to be valid and reliable. This study evaluated pharmacists’ perceptions of their work performance and their ability to perform their roles, duties, and functions in the hospital. A total of 192 pharmacist respondents answered 61 statements in the questionnaire that were divided into 11 dimensions as follows:1) the objectives set; 2) following the procedure; 3) initiatives; 4) performing the main task; 5) the ability to cooperate; 6) out implementing pharmaceutical standards; 7) the potential for solving problems; 8) quick response; 9) self-competence; 10) the ability to take verbal orders and writing; and 11) endurance at work. Results: The various answers of respondents to the questionnaire led to the conclusion that pharmacists' performance in hospitals is included in the high-performance category. Conclusion: This study showed that pharmacists have a high perception of their ability to work, as outlined in their assessment of their work performance in hospitals. Pharmacists' perceptions of their workplace performance in public hospitals are useful for developing pharmaceutical services. The results of this study are expected to provide a basis for improving the performance of pharmacists working in hospitals, especially hospitals in the Yogyakarta area. Keywords: performance, perception, pharmacist

2023-08-02T00:00:00Z Khairi, Widayatul Harmastuti, Nuraini Pamudji Widodo, Gunawan http://localhost:8080/xmlui/handle/123456789/7563 2024-11-08T03:16:28Z 2023-08-02T00:00:00Z

Title: In vivo Evaluation of Extracted and Fraction of Moringa oleifera leaves against Testosterone-Induced PCOS Model in Rattus Norvegicus Authors: Khairi, Widayatul; Harmastuti, Nuraini; Pamudji Widodo, Gunawan Abstract: Abstract Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder. Parameters characteristic of the disorder include weight gain, insulin resistance and malondialdehyde (MDA). The traditional medicine used is Moringa oleifera. Objectives: The aim was to determine the effect of weight loss and blood glucose levels, MDA levels and histopathological features of the ovarian follicles in the rat model PCOS-insulin resistance induced by testosterone. Methods: Extraction process, followed by fractionation using n-hexane, ethyl acetate and water, identification of compound content using TLC, and rats were grouped into 7 groups (n=5), namely normal group, negative group, positive group, extract, fraction water, ethyl acetate fraction and n-hexane fraction by looking at the characteristic parameters and ovarian histopathology. Data analysis using ANOVA and Kruskal-wallis. Results: The yield of the extract was 30.4%, the water fraction was 85.59%, the ethyl acetate fraction was 6.64% and the n-hexane fraction was 4.05%. Positive for flavonoids, tannins, alkaloids in the ethyl acetate fraction, the water and extract fractions were positive for tannins, the n-hexane fraction was positive for steroids. The modeling sample group obtained extract body weight 195.40 g, water fraction 195.80 g, ethyl acetate fraction 194.00 g, nhexane fraction 196.00 g, blood glucose level extract 83.00 mg/dL, water fraction 84.27 mg/dL, ethyl acetate fraction 80.00 mg/dL, n-hexane fraction 122.85 mg/dL, MDA extract content 2.704 nmol/mL, water fraction 3.547 nmol/mL, 1.685 nmol/mL, 5.308 nmol /mL and can improve ovarian histopathology. Conclusion: The most effective value is the ethyl acetate fraction because it has the highest decrease in PCOS characteristics. Keywords: follicles, malondialdehyde, moringa ethyl acetate fraction, Moringa oleifera, polycystic ovary syndrome

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