1 - 206 http://localhost:8080/xmlui/handle/123456789/7392 2026-04-16T11:42:52Z 2026-04-16T11:42:52Z Patel, Vrushank Sadiq, Muhammad S. Najeeb, Shariq Khurshid, Zohaib Zafar, Muhammad S. Heboyan, Artak http://localhost:8080/xmlui/handle/123456789/7455 2024-11-07T03:30:30Z 2023-01-01T00:00:00Z

Title: Effects of metformin on the bioactivity and osseointegration of dental implants: A systematic review Authors: Patel, Vrushank; Sadiq, Muhammad S.; Najeeb, Shariq; Khurshid, Zohaib; Zafar, Muhammad S.; Heboyan, Artak Abstract: Dental implants are prosthetic devices that are surgically placed in direct contact with the jawbone to support intra-oral functions and esthetics. Diabetes mellitus may contribute to peri-implant bone loss. During the last few years, there have been attempts to reduce this bone loss and improve the survival rate of implants. Metformin, an anti-diabetic drug known for its osteogenic properties, is thought to prevent peri-implant bone loss in diabetic patients. Although several studies have been conducted to study metformin’s effect on diabetic and non-diabetic study models, no systematic review has analyzed and summarized these studies critically. Therefore, the objectives of this systematic review were to summarize the outcomes of these studies and critically appraise them. Seven studies were included in this systematic review. Four studies used only animal models, two used both animal and cell culture models, and one used only cell culture studies. The general characteristics and outcomes of the included studies were summarized, and Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were used to assess the quality of the animal studies. In vitro studies indicate that metformin may induce stem cells to undergo osteoblastic differentiation to produce a higher amount of bone and may also improve osseointegration. Nevertheless, several studies had potential sources of bias. Therefore, it is recommended that emphasis be placed on increasing the quality of future animal studies and human trials to determine the effects of metformin on the osseointegration of dental implants. Future studies are needed with adequate follow-up to evaluate the efficacy of metformin in improving the osseointegration of dental implants.

2023-01-01T00:00:00Z Radithia, Desiana Tanjungsari, Rindang Ernawati, Diah Savitri Parmadiati, Adiastuti Endah http://localhost:8080/xmlui/handle/123456789/7454 2024-11-07T03:28:15Z 2023-01-01T00:00:00Z

Title: The effectiveness of essential oil from Citrus limon peel on Candida albicans biofilm formation: An experimental in vivo study Authors: Radithia, Desiana; Tanjungsari, Rindang; Ernawati, Diah Savitri; Parmadiati, Adiastuti Endah Abstract: Objectives: Candida albicans is resistant to commercial antifungal agents. Therefore, it is desirable to use material derived from natural sources as an antifungal agent. Essential oil from Citrus limon peel is able to inhibit the growth of C. albicans in vitro. The purpose of this study was to determine the most effective concentration of essential oil from C. limon peel with regards to the inhibition of C. albicans cyto-morphometric changes and biofilm formation in vivo. Methods: Male Wistar rats weighing 200e300 g were inoculated with C. albicans for 48 h and then given a single dose of oral methylprednisolone as an immunosuppressant. Essential oil from C. limon peel, in a gel form and at three different concentrations (0.39%, 0.78% and 1.56%), was applied twice a day for 2 days. The rats were killed after 48 h and then palatal mucosa tissues were prepared and examined with a scanning electron microscope (SEM) with regards to C. albicans, cytomorphometric changes and biofilm formation. Results: Essential oil from C. limon peel at a concentration of 1.56% showed the strongest ability to inhibit C. albicans growth when compared to 0.78% and 0.39%. At a concentration of 1.56%, essential oil from C. limon peel disrupted cyto-morphometric changes; cells that were neither in intact nor colonised were evident, the filaments around the cells were smooth, the layer of biofilm had disappeared and there was no evidence of hyphae formation. Conclusion: The effect of essential oil from C. limon peel on cyto-morphometric changes and biofilm formation was concentration-dependent. Essential oil from C. limon peel at a dose of 1.56% showed the strongest ability to inhibit cyto-morphometric changes and biofilm formation. These findings demonstrate that essential oil of C. limon peel is a potential antifungal candidate for the treatment of candidiasis.

2023-01-01T00:00:00Z Hernandez-Vasquez, Akram Visconti-Lopez, Fabriccio J. Alburqueque-Cruz, Renato Rojas-Roque, Carlos http://localhost:8080/xmlui/handle/123456789/7451 2024-11-07T03:26:42Z 2023-01-01T00:00:00Z

Title: Hospitalizations and mortality of patients with heart failure in the COVID-19 era in Peru Authors: Hernandez-Vasquez, Akram; Visconti-Lopez, Fabriccio J.; Alburqueque-Cruz, Renato; Rojas-Roque, Carlos Abstract: Objectives: The worldwide heart failure (HF) prevalence is 8.52 per 1000 inhabitants, with a global economic burden of 346.17 billion dollars. With the COVID-19 pandemic, the focus of medical care has changed to treating the morbidity and mortality of patients with COVID-19 and reducing medical procedures or visits to patients with HF, with the impact being greater in lowand middle-income countries. Methods: We performed an interrupted time series analysis of HF to determine the changes in the trend of hospitalizations and in-hospital mortality of HF patients before and after the mandatory lockdown in Peru. Results: A total of 18,514 adults were included in the analysis. Monthly hospital admissions immediately decreased by 599 (95% confidence interval [CI]: 113 to 1085) and the difference in slope before and after the lockdown was 6.4 hospital admissions (95% CI: 4 to 18). In-hospital mortality increased by 18% (95% CI: 8%e43%) and the difference in slope before and after the lockdown was 0.3% (95% CI: 0.9%e0.25%). Conclusions: There was a reduction in hospitalizations and an increase in the in-hospital mortality of patients with HF before and after the mandatory lockdown due to the COVID-19 pandemic in Peru.

2023-01-01T00:00:00Z Alamro, Ahmad S. Alghasham, Abdullah A. Al-Shobaili, Hani A. dkk. http://localhost:8080/xmlui/handle/123456789/7450 2024-11-07T03:22:30Z 2023-01-01T00:00:00Z

Title: 10 years of experience in adopting, implementing and evaluating progress testing for Saudi medical students Authors: Alamro, Ahmad S.; Alghasham, Abdullah A.; Al-Shobaili, Hani A.; dkk. Abstract: Objectives: The progress test (PT) is a comprehensive examination that is designed to match the knowledge acquisition necessary at graduation and monitors progress during the entire period of an undergraduate program. Qassim College of Medicine (QCM) began using the multi-institutional PT in the Kingdom of Saudi Arabia (KSA). This study aimed to determine if the PT can be utilized to assess the progress of medical students at different Saudi medical colleges with different educational approaches, as well as whether this testing modality could be accepted by other colleges. Methods: Beside the establishment of a PT committee, comprehensive blueprinting was crafted to sample 200 Atype multiple choice questions (MCQs) from different disciplines. The PT is a paper-and-pencil model and is answered in a 4-h period. All PT items followed a uniform design. Results: In total, 13 rounds of the progress test have been conducted. The number of participating colleges increased from three (with 285 students) in the first test (May 2012) to more than 20 (with >6000 students) in the ninth round (February 2017). The average % scores for first-year students ranged from 3.0% to 7.9% while the average scores for fifth-year students ranged from 34.0% to 43.0%. Conclusion: The conduction of this meticulously crafted test to evaluate knowledge achievement at medical graduation is a fruitful tool and helps to provide constructive feedback for test-takers and other stakeholders relating to their relative positions among other fellows at the national level.

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