http://localhost:8080/xmlui/handle/123456789/7366 2026-04-09T04:06:37Z 2026-04-09T04:06:37Z Molidia, Sri Rahmat Pramantara, Dewa Putu Ikawati, Zullies http://localhost:8080/xmlui/handle/123456789/7381 2024-11-07T01:42:44Z 2024-04-01T00:00:00Z

Title: Comparison of Clinical Outcomes between Acetylcysteine and Ambroxol in Post Acute Exacerbation of COPD Patients Authors: Molidia, Sri Rahmat; Pramantara, Dewa Putu; Ikawati, Zullies Abstract: acerbation chronic obstructive pulmonary disease (AECOPD) patients. This study aims to compare the clinical outcomes of acetylcysteine and ambroxol administration in post AECOPD patients. The study was cohort design, prospective, to comparison of clinical outcomes of acetylcysteine and ambroxol with post AECOPD outpatients coming for clinical chekups in August 2023 at Respira Lung Hospital Yogyakarta. Clinical outcomes parameters were observed on day zero and thirty for CAT score and day zero and four for cough score. The patients were categorized into two groups: acetylcysteine group (n=30) and ambroxol group (n=30). There was no significant difference between two groupsto change of CAT score and cough score (p>0.05) post AECOPD. The acetylcysteine group compared to ambroxol, there was a mean decrease in morning cough score -1.10±1.11 vs -0.87±1.12 (p=0.228), night cough score -1.53±1.43 vs -1.13±1.31 (p=0.438), and CAT score -2.43±5.45 vs -2.90±3.41 (p=0.391). Providing additional therapy of acetylcysteine or ambroxol in this study did not significantly reducing cough scores and CAT scores in post AECOPD patients.

2024-04-01T00:00:00Z Rohmani, Sholichah Mar’atushsholihah, Luthfia Darojati, Ulfa Afrinurfadhillah Meitasari, Annisa Diyan Susanto, Bela Novita Amaris http://localhost:8080/xmlui/handle/123456789/7380 2024-11-07T01:36:59Z 2024-04-01T00:00:00Z

Title: Formulation and Activity of Sunscreen Cream from Ethanol Extract of Calendula Officinalis L Flowers Authors: Rohmani, Sholichah; Mar’atushsholihah, Luthfia; Darojati, Ulfa Afrinurfadhillah; Meitasari, Annisa Diyan; Susanto, Bela Novita Amaris Abstract: Sunscreen made of natural ingredients is an alternative to protect the skin from excess UV radiation and a substitute for chemical products that have side effects. It was reported that Calendula officinalis L. has flavonoid and saponin metabolite compounds, which function as photoprotective agents. This research aims to formulate sunscreen cream and examine the effect of variations in Calendula officinalis L flower extract (5%;7%;10% w/v) on physicochemical properties, stability, and values of the Sun Protecting Factor (SPF) in vitro using UV-Vis spectrophotometry and in vivo using Wistar line rat test animals to see the time of formation of Minimum Erythema Dose (MED). It has been proven that variations in the concentration of Calendula officinalis L. extract affected the physicochemical properties, such as pH value, viscosity, spreadability, and adhesion strength. However, the overall results of the physicochemical properties still met the requirements. Variations in extract concentration affected the SPF value. In vitro SPF test showed the minimum protection category for F1, extra protection for F2, maximum protection for F3, and no protection for F0. Meanwhile, the in vivo SPF test showed the minimal protection category for F1, medium protection for F2, extra protection for F3, and no protection for F0.

2024-04-01T00:00:00Z Fatimah, Siti Fatmawati Farida, Verda Nuari, Yudha Rizky Viviandhari, Daniek Pertiwi, Deasy Vanda http://localhost:8080/xmlui/handle/123456789/7379 2024-11-07T01:31:49Z 2024-04-01T00:00:00Z

Title: Investigating the Impact of Surfactant and Cosolvent on the Polyphenolic Content in Arumanis Mango Leaf Extract (Mangifera indica L.) Authors: Fatimah, Siti Fatmawati; Farida, Verda; Nuari, Yudha Rizky; Viviandhari, Daniek; Pertiwi, Deasy Vanda Abstract: The leaf of Mangifera indica L. contains flavonoids and mangiferin which showed positive effects on wound healing of diabetic ulcer. The used of suitable surfactant and co-solvent is required to ensure the high solubility of the active pharmaceutical ingredient (API), thereby optimizing the efficacy. This study aims to determine the ideal surfactant and cosolvent for a thermosensitive hydrogel formula of Mangifera indica leaf ethanol extract. The leaf was extracted by maceration using 70% ethanol then determined for moisture content. The extract was prepared for solubility tests of flavonoid and mangiferin on surfactants (Kolliphor® EL, Tween® 20, Tween® 80, Miranol® C2M) and co-solvents (Glycerin, PEG 400, and Transcutol). Determination of total flavonoids content was carried out using Spectrophotometry UV-Vis method and mangiferin content was determined using the RP-HPLC . The moisture content in the extract was 8.590 ± 0.754%. The surfactant demonstrating the highest capability in flavonoid dissolution was Tween 20 (1863.750 ± 0.838 µgQE/g extract), followed by Tween 80, Kolliphor EL, and Miranol C2M. In the context of co-solvents, PEG 400 (1309.583 ± 0.292 µgQE/g extract) show ed superior flavonoid dissolution capability, with glycerin and Transcutol continued to decrease sequentially. Tween 20 and Tween 80 showed comparable efficacy in mangiferin dissolution, followed by Miranol C2M and Kolliphor EL. Among co-solvents, Transcutol demonstrate the highest potential for mangiferin dissolution, succeeded by PEG 400 and glycerin. This study suggests that Tween 20 is a preferred surfactant, and PEG 400 was identified as a co-solvent for use in a thermosensitive gel formula for diabetic ulcers.

2024-04-01T00:00:00Z Fitria, Najmiatul Syaputri, Yolanda Zazna Akram, Muhammad Nasif, Hansen Mardatillah http://localhost:8080/xmlui/handle/123456789/7375 2024-11-06T08:21:56Z 2024-04-01T00:00:00Z

Title: Amlodipine-Candesartan Combination: A Cost-Effective Strategy for Successful Therapy of Hypertension Authors: Fitria, Najmiatul; Syaputri, Yolanda Zazna; Akram, Muhammad; Nasif, Hansen; Mardatillah Abstract: Introduction: The combination of amlodipine and candesartan can have a better effect, although the costeffectiveness analysis was not yet determined. This research aimed to establish the Incremental Cost-Effectiveness Ratio (ICER) value among outpatients with hypertension who used amlodipine-candesartan. Method: This research was a descriptive study that retrospectively gathered data from medical records . Medical records data focused on information for hypertensive patients at Universitas Andalas Hospital in 2021. This study compared the standard treatment involving amlodipine-candesartan and sole amlodipine, next to calculate the ICER using cost-effectiveness analysis. Results: Out of the total population of 284, as many as 73 patients were involved in this study. Among these, 21 patients (28.77%) were treated with amlodipine alone, while 52 (71.23%) received an amlodipine-candesartan combination. The Incremental Cost-Effectiveness Ratio (ICER) for reducing systolic blood pressure was IDR 74,738.10 per one mmHg decrease in the northeast quadrant of the cost-effectiveness chart. The ICER for lowering diastolic blood pressure was IDR 205,918.24 per one mmHg decrease in the northeast quadrant on the cost-effectiveness chart. Conclusion: The cost of the amlodipine-candesartan combination yields superior effects; however, warranting a probabilistic sensitivity analysis to determine its ICER robustness is essential for its effective implementation.

2024-04-01T00:00:00Z