DSpace Collection: 725 - 927

Factors of life satisfaction and happiness among dentists: A cross sectional study

2024-11-06T06:47:52Z

Title: Factors of life satisfaction and happiness among dentists: A cross sectional study Authors: Abay, Feridun; Buyuk, S. Kutalmıs; Turken, Recep Abstract: Objectives: The present study aimed to determine the levels of happiness among dentists and to investigate their associations with emotional well-being and satisfaction with life. Methods: Dentists in Turkey were surveyed with 25 questions on age, gender, place of work, and years of experience, and a five-item life satisfaction scale. Results: A total of 486 dentists completed the survey. Dentists’ workplaces and professional titles were associated with their life satisfaction scores. Most dentists (n ¼ 373; 76.25%) reported feeling pressured in their work environment, and the institution where they worked was significantly associated with the degree of pressure (p < 0.001). Institution (p < 0.001), job title (p < 0.001), and work experience (p < 0.019) were significant factors in whether they would recommend their profession to others. Dentists’ institutions and titles were significantly associated with life satisfaction (p < 0.001). Conclusions: Our findings suggest that dentists in Turkey have a low life satisfaction with respect to that of other professionals and dentists from other countries. In addition, the factors associated with life satisfaction vary.

Nano-emulsion of mangosteen rind extract in a mucoadhesive patch for periodontitis regenerative treatment: An in vivo study

2024-11-06T06:42:41Z

Title: Nano-emulsion of mangosteen rind extract in a mucoadhesive patch for periodontitis regenerative treatment: An in vivo study Authors: Aljuanid, Mohammed A.; Qaid, Huda R.; Lashari, Dur M.; Ridwan, Rini D.; Budi, Hendrik S.; Alkadasi, Baleegh A.; Ramadhani, Yeka; Rahmasari, Riski Abstract: Objective: To investigate the therapeutic potential of nano-emulsion of mangosteen rind extract in a mucoadhesive gingival patch on periodontitis, and its effect on tumor necrosis factor alpha (TNF-a), receptor activator of nuclear factor kappa B ligand (RANKL), and interleukin 10 (IL-10) expression. Methods: Sixty Wistar rats were divided into four groups: positive control group (mucoadhesive patch with doxycycline), negative control group (mucoadhesive patch), treatment group I (mucoadhesive patch with mangosteen rind extract), and treatment group II (mucoadhesive patch with nano-emulsion of mangosteen rind extract). An experimental model of Porphyromonas gingivalis-induced periodontitis was established in rats by treatment with 0.03 mL bacteria locally (1 1010 colonyforming units) seven times at 2-day intervals in the gingival sulcus of mandibular anterior teeth. Treatment was 1 h/day for 3 days. On days 3, 5, and 7, five rats from each group were killed. TNF-a, IL-10, and RANKL expression was determined by dissecting the lower jaw for immunohistochemistry. Results: The mucoadhesive patch with nano-emulsion mangosteen rind extract significantly decreased TNF-a and RANKL expression and increased IL-10 expression (p < 0.05) compared to the treatment I, positive and negative control groups. Conclusion: A mucoadhesive gingival patch with nanoemulsion of mangosteen rind extract has the potential to treat periodontitis by decreasing TNF-a, RANKL, and increasing IL-10 expression.

Multifocal oral squamous cell carcinoma post haematopoietic stem cell transplantation: A case report

2024-11-06T05:02:50Z

Title: Multifocal oral squamous cell carcinoma post haematopoietic stem cell transplantation: A case report Authors: Rahman, Nurhayu Ab; Othman, Nik Aida Nasuha Nik Abstract: Oral squamous cell carcinoma is considered a rare complication of post-haematopoietic stem cell transplantation (HSCT). Early detection of these lesions is further complicated by the overlapping clinical appearance and presentation of lesions associated with chronic graft versus host disease (cGVHD). We report a case of oral squamous cell carcinoma in a 33 year-old man who presented with severe intraoral pain on the lower left side of the cheek and jaw 19 months after undergoing HSCT for the treatment of underlying acute lymphoblastic leukaemia. He was previously treated with intravenous cyclophosphamide as a conditioning regimen for HSCT and later developed cGVHD of the liver, eyes, and gut, which resolved with treatment. Intraoral examination revealed two separate lesions. The first lesion presented as a raised oval nodular swelling with a well-circumscribed margin and irregular surface on the left buccal mucosa. A similar, but more extensive, lesion was noted on the left lingual gingiva and was associated with spontaneous bleeding. Biopsy revealed that both lesions were welldifferentiated squamous cell carcinomas and were p16 positive. He underwent palliative radiotherapy but succumbed to his disease 3 months after initiation of treatment.

Whole-transcriptome bioinformatics revealed HTRA3, KRT8, KRT17, and RHEX as novel targets in acute myeloid leukaemia

2024-11-06T04:57:20Z

Title: Whole-transcriptome bioinformatics revealed HTRA3, KRT8, KRT17, and RHEX as novel targets in acute myeloid leukaemia Authors: El-Masry, Omar S.; Alshwareb, Abeer A.; Alnasser, Fatimah H.; mishaal, Sukainah G. al; Alsamman, Khaldoon M. Abstract: Acute myeloid leukaemia (AML) is characterised by heterogeneous genomic signatures that vary among different patient groups. Hence, the current study aims to conduct a whole transcriptome analysis of a female patient with AML and a family history of the disease at the time of diagnosis. Genetic profiling has a useful impact on clinical management and treatment success of the disease as the complex genetic landscape of AML and differential responses to treatment might indicate inadequate therapeutic targeting. A 37 year old female patient with AML was admitted to the hospital complaining of general fatigue arthralgia and chest pain. AML diagnosis was confirmed by complete blood count and blood smears before being confirmed by cytogenetic analysis. Herein, we conducted whole-transcriptome sequencing analysis to assess differential gene expression profiles in patients and healthy control subjects. In addition, single nucleotide polymorphism/insertion-deletion analyses (SNP/INDEL) were performed to investigate gene variants in the present case. The results revealed a remarkable differential gene expression profile in AML compared to the corresponding control at the time of diagnosis, indicating that HTRA3, KRT8, KRT17, and RHEX are potential novel therapeutic targets. Additionally, a number of novel gene variants were also reported in the current study, as concluded from the SNP/INDEL analysis, which might be associated with disease risk assessment and probably affect prognosis. These genes and their new variants might be worth reporting to the scientific community for further exploration of AML.