http://localhost:8080/xmlui/handle/123456789/7213 2026-04-09T05:13:08Z 2026-04-09T05:13:08Z Parwatininghati, Ni Putu Rahmawati, Fita Sajinadiyasa, I Gede Ketut http://localhost:8080/xmlui/handle/123456789/7256 2024-11-02T04:52:18Z 2023-08-01T00:00:00Z

Title: Efek Samping Obat Gefitinib pada Pasien Kanker Paru dengan Epidermal Growth Factor Receptor (EGFR) Mutasi Positif Authors: Parwatininghati, Ni Putu; Rahmawati, Fita; Sajinadiyasa, I Gede Ketut Abstract: Detection of Epidermal Growth Factor Receptor (EGFR) mutations in lung cancer patients will help in selecting targeted therapy, such as gefitinib. Studies regarding the safety profile evaluation from gefitinib in Indonesia are very limited. Hence, this study aims to determine hematological and non-hematological side effects of gefitinib in lung cancer patients with positive EGFR mutations. The study design was an observational cross sectional. Secondary data was taken from medical records from 2020 to 2022 on 44 patients. The probability of side effects was measured using the Naranjo Adverse Drug Reaction Probability Scale, and the severity of side effects was assessed using the Common Terminology Criteria for Adverse Events (CTCAE). The results showed that the most frequent hematological side effect was anemia grade 1 in 18 patients (40.91%). For non-hematological side effects, grade 2 rash predominated in 20 patients (45.46%), 14 patients (31.82%) experienced grade 1 in elevated serum transaminase, grade 1 diarrhea occurred in 5 patients (11.36%), and grade 2 nausea-vomiting experienced by 3 patients (6.82%). Total of 36 patients (81.82%) experienced side effects, with 19 events included in the possible category and 17 events included in the probable category. Side effects are mild, manageable, and not cumulative. There was no dose adjustment or discontinuation of the drug caused by drug side effects.

2023-08-01T00:00:00Z Windha Andriati, Syarifah Lisa http://localhost:8080/xmlui/handle/123456789/7253 2024-11-02T04:45:49Z 2023-08-01T00:00:00Z

Title: Studi Terhadap Dampak Perjanjian Integrasi Vertikal pada Industri Farmasi Ditinjau dari Perspektif Hukum Persaingan Usaha Authors: Windha; Andriati, Syarifah Lisa Abstract: The pharmaceutical industry in Indonesia shows a relatively high market concentration and tends towards oligopoly, making it vulnerable to vertical integration agreements that can lead to unhealthy competition. Vertical integration agreements in the pharmaceutical industry can create efficiency but can also be a means for businesses to hinder competition because such agreements can cause market foreclosure. The problem addressed in this writing is how vertical integration agreements affect the pharmaceutical industry and what testing principles are used to prove vertical integration agreements that have anti-competitive impacts in the pharmaceutical industry. The research method is juridical-normative research method using secondary data in the form of laws regulations and the results of KPPU's initial research used to analyze the issues. Data analysis uses qualitative analysis by processing data into a response to answer the problem. The results of this journal research are that the positive impact of vertical integration in the pharmaceutical industry can create efficiency, increase marketing size, and strengthen supply stability. However, the negative impact is that vertically integrated companies will have the ability to create market foreclosure. The approach used to prove violations of vertical integration agreements is the rule of reason approach with the testing principles of analyzing capability, incentive, and consumer impact. Therefore, it must be further proven whether there is an impact from vertical integration agreements in the pharmaceutical industry that has led to anti-competitive impacts. Suggestions that can be given are that the government or competing businesses are expected to conduct further studies on pharmaceutical companies that have vertical integration agreements to analyze the impacts of such agreements. Then, the results of the study on businesses that have vertical integration agreements in the pharmaceutical industry should be followed up if there are indications of violations of vertical integration agreements in the pharmaceutical industry

2023-08-01T00:00:00Z Elfiyani, Rahmah Nursal, Fith Khaira Deviyolanda, Reza Shifa http://localhost:8080/xmlui/handle/123456789/7230 2024-11-01T04:29:03Z 2023-08-01T00:00:00Z

Title: Pemanfaatan Ekstrak Kulit Putih Semangka Dalam Sediaan Masker Clay Authors: Elfiyani, Rahmah; Nursal, Fith Khaira; Deviyolanda, Reza; Shifa Abstract: The citrulline contained in the white skin of watermelon (Citrullus lanatus) has an antioxidant activity that is beneficial for skin health, so it has the potential to be formulated in clay face masks. The purpose was to investigate the effect of various concentration of mineral bases (bentonite and kaolin) on the physical properties of the watermelon white peel extract clay mask. The extract was made by maceration method using ethanol 70% as a solvent. Furthermore, masks were made with various concentrations of bentonite/kaolin, and the mask's physical properties were evaluated. Each data obtained from clay-bentonite masks and clay-kaolin masks were analyzed statistically using one-way ANOVA. Clay masks with a bentonite base showed a pH value of 3.38-4.86 and a spreadability of 2.24-4.15. Meanwhile, clay masks with a kaolin base showed a pH value of 4.75-5.23 and a spreadability of 4.59-5.06. It can be concluded that increasing the mineral base concentration with an interval of 4%-5% in the range of 20–35% can reduce the pH value, drying time, and spreadability and increase the viscosity of the watermelon white peel extract clay mask. Using kaolin base in clay masks requires a lower concentration than bentonite base to obtain good physical properties of the preparation.

2023-08-01T00:00:00Z Wirastuti, Ken Sari, Amalia Nirma Dewi, Dwi Arditi Setyaningrum, Widya Ayu Hussaana, Atina http://localhost:8080/xmlui/handle/123456789/7228 2024-11-01T04:22:54Z 2023-08-01T00:00:00Z

Title: Perbandingan Efikasi Karbamazepin, Gabapentin dan Amitriptilin terhadap Nyeri pada Penderita Polineuropati Diabetik Authors: Wirastuti, Ken; Sari, Amalia Nirma; Dewi, Dwi Arditi; Setyaningrum, Widya Ayu; Hussaana, Atina Abstract: ifferences in the mechanism of action of the drugs Carbamazepine, Gabapentin, and Amitriptyline can affect their effectiveness in reducing pain in diabetic polyneuropathy. To help select the most appropriate therapy to manage the pain, it is necessary to conduct this research. The research was conducted experimentally using a pretest-posttest group design. Pain response was measured using the Visual Analogue Scale (VAS) before and after treatment with Gabapentin, Carbamazepine, and Amitriptyline. Differences in pain response before and after treatment, as well as between treatments, were analyzed using the Mann-Whitney test and independent T-test. The results demonstrated that all three drugs were effective in reducing pain response in patients with diabetic polyneuropathy. However, Amitriptyline was found to be more effective in patients with mild to moderate pain compared to Gabapentin. These findings provide valuable information for healthcare providers in selecting the most effective treatment for patients with diabetic polyneuropathy pain.

2023-08-01T00:00:00Z